Q9UTR6

PR
Gene name
och1
Protein name
Initiation-specific alpha-1,6-mannosyltransferase
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1006.05c
EC number
2.4.1.232: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UTR6

Entry ID Method Resolution Chain Position Source
AF-Q9UTR6-F1 Predicted AlphaFoldDB

2 variants for Q9UTR6

Variant ID(s) Position Change Description Diseaes Association Provenance
I_5079905_C_T 158 V>I No Jeffares_SNPs
I_5079770_C_T 203 A>T No Jeffares_SNPs

No associated diseases with Q9UTR6

6 regional properties for Q9UTR6

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 161 - 327 IPR005225
domain GTP binding domain 161 - 274 IPR006073
conserved_site GTP1/OBG, conserved site 219 - 232 IPR006074
domain GTP1/OBG domain 1 - 159 IPR006169
domain GTP-binding protein OBG, C-terminal 357 - 435 IPR015349
domain OBG-type guanine nucleotide-binding (G) domain 160 - 332 IPR031167

Functions

Description
EC Number 2.4.1.232 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type II membrane protein
  • Golgi apparatus membrane ; Single-pass type II membrane protein
  • Is recycled between the trans-Golgi network and a late compartment of the endoplasmic reticulum
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
mannan polymerase complex A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.
mannan polymerase II complex A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p.

3 GO annotations of molecular function

Name Definition
alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.
glycolipid 1,6-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.
mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

4 GO annotations of biological process

Name Definition
cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
dolichol-linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRLRLRSIV IGAAIAGSIL LLFNHGSIEG MEDLTEISML EDYTPEAANK DYVGQQEEEE
70 80 90 100 110 120
LLYDQPSYIE EEEDPDLEAY LSDLEREELE HSLEELDEEN NYKLHLRYSF SQLQDFDEEN
130 140 150 160 170 180
EAVHMIVPKD TYEFEVPYHA DIPKLIWQTS KDPFDREVMK YTRFWRINHP SYSHAVLDDE
190 200 210 220 230 240
QSKALVISSF GDSSVSKISQ AYAMMPLPVL KADFFRYLVL LAKGGIYSDI DTAPLKHINN
250 260 270 280 290 300
WIPREYRKRN IRLIVGIEAD PDRPDWNDYY ARRVQFCQWT IAAAPGHPIL WELVRRITDE
310 320 330 340 350 360
TWKLHDSKKL SKNGESVMEW TGPGIWTDAI MDYLNWQYGP FSVENITNLE EPYLVGDVLI
370 380 390
LPITAFSPGV GHMGSKSPND PMAYVQHFFA GSWKDD