Q9UTN6

PR
Gene name
snf21 (SPAC1250.01, SPAC29A4.21)
Protein name
Chromatin structure-remodeling complex subunit snf21
Names
ATP-dependent helicase snf21, RSC complex subunit snf21
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC1250.01
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

984-1087 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UTN6

Entry ID Method Resolution Chain Position Source
AF-Q9UTN6-F1 Predicted AlphaFoldDB

11 variants for Q9UTN6

Variant ID(s) Position Change Description Diseaes Association Provenance
I_5103974_T_A 15 T>S No Jeffares_SNPs
I_5103872_T_A 35 Y>F No Jeffares_SNPs
I_5103582_C_T 132 G>S No Jeffares_SNPs
I_5103513_C_T 155 D>N No Jeffares_SNPs
I_5103413_A_G 188 L>S No Jeffares_SNPs
I_5103365_A_G 204 L>S No Jeffares_SNPs
I_5103176_T_C 267 K>R No Jeffares_SNPs
I_5102751_G_T 409 P>T No Jeffares_SNPs
I_5101126_C_A 950 R>S No Jeffares_SNPs
I_5100502_G_T 1158 N>K No Jeffares_SNPs
I_5100491_G_T 1162 T>K No Jeffares_SNPs

No associated diseases with Q9UTN6

No regional properties for Q9UTN6

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9UTN6

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Localizes to centromeric and flanking chromatin
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
RSC-type complex A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
chromatin-protein adaptor The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone octamer slider activity A chromatin remodeler activity that slides core histone octamers along chromosomal DNA.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

5 GO annotations of biological process

Name Definition
chromatin remodeling A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
mitotic cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRAEKQYTRN EVEETIVRWK KLKESGATEH DNTEYAQLCD VLRSAQSEIE ARRDLKGHIK
70 80 90 100 110 120
RCFSSVDKNT EKLILKQQVL AYKKLSQNLP APDDCILSVL LRLSKDEQLL QSIVKQPLQN
130 140 150 160 170 180
SKVDGKVRRD FGSCQITPSA KQQRKYLQYQ ISEDDAIKNR MFRRMSDLES YPAVMRDVAE
190 200 210 220 230 240
LKDDNERLNL DTIKRNALVE LKKLRLIKQQ ESLRHQVMHC QPHLRTIVNA VERMSCRRPK
250 260 270 280 290 300
LVPQATRLTE VLERQQRSDR ERRLKQKQCD YLQTVCAHGR EINVRTKNAQ ARAQKANRAV
310 320 330 340 350 360
LAYHSHIEKE EQRRAERNAK QRLQALKEND EEAYLKLIDQ AKDTRITHLL RQTDHYLDSL
370 380 390 400 410 420
AAAVKVQQSQ FGESAYDEDM DRRMNPEDDR KIDYYNVAHN IREVVTEQPS ILVGGKLKEY
430 440 450 460 470 480
QLRGLQWMIS LYNNHLNGIL ADEMGLGKTI QTISLITHLI EKKRQNGPFL VIVPLSTLTN
490 500 510 520 530 540
WTMEFERWAP SIVKIVYKGP PQVRKALHPQ VRHSNFQVLL TTYEYIIKDR PLLSRIKWIY
550 560 570 580 590 600
MIIDEGHRMK NTQSKLTNTL TTYYSSRYRL ILTGTPLQNN LPELWALLNF VLPRIFNSIK
610 620 630 640 650 660
SFDEWFNTPF ANTGGQDKME LTEEESLLVI RRLHKVLRPF LLRRLKKDVE AELPDKVEKV
670 680 690 700 710 720
IRCQMSGLQQ KLYYQMKKHG MLYVEDAKRG KTGIKGLQNT VMQLKKICNH PFVFEDVERS
730 740 750 760 770 780
IDPTGFNYDM LWRVSGKFEL LDRILPKLFR SGHRILMFFQ MTQIMNIMED YLHYRQWRYL
790 800 810 820 830 840
RLDGSTKADD RSKLLGVFND PTAEVNLFLL STRAGGLGLN LQTADTVIIF DSDWNPHQDL
850 860 870 880 890 900
QAQDRAHRIG QTKEVRIYRL ITEKSVEENI LARAQYKLDI DGKVIQAGKF DNKSTPEERE
910 920 930 940 950 960
AFLRSLLENE NGEEENDEKG ELDDDELNEI LARGDDELRL FKQMTEDLER ESPYGKNKEK
970 980 990 1000 1010 1020
ERLIQVSELP EFYQREEPEK TTDLLQEEPL GRGARRRTPV VYDEAVRDAQ WMAEMDMESE
1030 1040 1050 1060 1070 1080
ARPTRGRPKR NIASVDETPA LTLNGKPKKK RGPAPDTLTS EHRSLLRRVC LEIYKAVNEL
1090 1100 1110 1120 1130 1140
EDDNGRPLNK LFLELPSKKL YPDYYMIIKS PIALDAIRKH INGTFYKTLE AMKSDLMTMF
1150 1160 1170 1180 1190
NNARTYNEEG SFVYEDANKM QTAMETKIEE LEEDGTLATL RGMEAEATSQ LEDRIENEA