Q9UTK7
Gene name |
dsc2 (ucp14, SPAC1486.02c) |
Protein name |
DSC E3 ubiquitin ligase complex subunit 2 |
Names |
Defective for SREBP cleavage protein 2, RING-type E3 ubiquitin transferase DSC2, UBA domain-containing protein 14 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC1486.02c |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9UTK7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9UTK7-F1 | Predicted | AlphaFoldDB |
6 variants for Q9UTK7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_3187297_T_A | 192 | L>F | No | Jeffares_SNPs | |
| I_3187175_G_A | 233 | T>I | No | Jeffares_SNPs | |
| I_3187163_A_G | 237 | L>P | No | Jeffares_SNPs | |
| I_3187107_C_T | 256 | V>I | No | Jeffares_SNPs | |
| I_3187056_T_C | 273 | T>A | No | Jeffares_SNPs | |
| I_3187037_G_T | 279 | S>Y | No | Jeffares_SNPs |
No associated diseases with Q9UTK7
No regional properties for Q9UTK7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9UTK7 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Dsc E3 ubiquitin ligase complex | An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intrinsic component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin protein ligase binding | Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| SREBP signaling pathway | The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSANIVPSN | MGITKFLLLT | ISTSSVVAGV | FALKPFFHIN | FGLHLLSHYQ | YWRILLWQFI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YWNSTEVFQA | LFIIYQARDV | ERLLGSHRFA | SFCVYMFILG | MFVTPIFSFL | YSLLFKNLDY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQPGPTFLIF | AILYQYYYIV | PSTVFVRLFN | IKFTDKFQMV | IPMIGLAFSH | FPSTFINAFL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GWTMGMFYHL | SLLPGTSWRL | PIRFVKPALS | PTHVFIRPPY | SDMQNASTFN | PETLFALPTG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDAERTENEN | QVENPVSNAD | ANDSPTRQNA | RATAIASSSN | TAASFRNRQQ | ISHPPLGRTS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSSVLPTGPA | SQLYDMLSGR | SERPELGNIR | EEDINTVQTI | MQTSRAQAIQ | ALSQTNDVQR |
| 370 | |||||
| AVELLLEQTA | DY |