Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9UTJ8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9UTJ8-F1 | Predicted | AlphaFoldDB |
14 variants for Q9UTJ8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_3794074_T_C | 564 | D>G | No | Jeffares_SNPs | |
| I_3793985_C_T | 594 | V>I | No | Jeffares_SNPs | |
| I_3793852_T_C | 638 | K>R | No | Jeffares_SNPs | |
| I_3793843_T_C | 641 | E>G | No | Jeffares_SNPs | |
| I_3793838_C_T | 643 | E>K | No | Jeffares_SNPs | |
| I_3793660_G_T | 702 | S>Y | No | Jeffares_SNPs | |
| I_3793579_T_C | 729 | D>G | No | Jeffares_SNPs | |
| I_3793531_A_T | 745 | L>H | No | Jeffares_SNPs | |
| I_3793466_C_T | 767 | D>N | No | Jeffares_SNPs | |
| I_3793224_A_T | 847 | F>L | No | Jeffares_SNPs | |
| I_3792848_C_T | 973 | E>K | No | Jeffares_SNPs | |
| I_3792691_T_C | 1025 | K>R | No | Jeffares_SNPs | |
| I_3792281_T_A | 1162 | T>S | No | Jeffares_SNPs | |
| I_3791844_T_C | 1282 | K>R | No | Jeffares_SNPs |
No associated diseases with Q9UTJ8
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| condensed nuclear chromosome | A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
| Mre11 complex | Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| DNA end binding | Binding to DNA ends exposed by the creation of double-strand breaks (DSBs). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| double-stranded telomeric DNA binding | Binding to double-stranded telomere-associated DNA. |
| G-quadruplex DNA binding | Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. |
| metal ion binding | Binding to a metal ion. |
| single-stranded telomeric DNA binding | Binding to single-stranded telomere-associated DNA. |
18 GO annotations of biological process
| Name | Definition |
|---|---|
| chromosome organization involved in meiotic cell cycle | A process of chromosome organization that is involved in a meiotic cell cycle. |
| DNA duplex unwinding | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. |
| double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. |
| double-strand break repair involved in meiotic recombination | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. |
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| double-strand break repair via nonhomologous end joining | The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. |
| gene conversion at mating-type locus | The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. |
| meiotic DNA double-strand break clipping | The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP). |
| meiotic DNA double-strand break formation | The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. |
| mitotic intra-S DNA damage checkpoint signaling | A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. |
| mitotic recombination-dependent replication fork processing | Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart. |
| nucleic acid phosphodiester bond hydrolysis | The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. |
| regulation of reciprocal meiotic recombination | Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. |
| replication fork processing | The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. |
| stalled replication fork localization to nuclear periphery | A cellular localization process where a DNA replication fork that has stalled is signaled to relocate and anchor to the nuclear periphery for the time necessary to complete recombination-dependent replication. |
| telomere maintenance | Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. |
| telomere maintenance via recombination | Any recombinational process that contributes to the maintenance of proper telomeric length. |
| telomere maintenance via telomerase | The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSCIDRMSIM | GIRSFDNRSR | ESIQFFSPLT | LIVGQNGSGK | TTIIECLKYA | TTGILPPNTK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGAFIHDPKI | CGEKEVLAQV | KLAFRNTNQV | KMICTRSLQL | SVKKTTRQQK | TLDGQLLILK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DNERTTISNR | CAELDSQVPL | SLGVSKALLD | YVIFCHQEES | FWPLSEPANL | KKRFDEIFES |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LRYAKALDQI | KGLKRDQETQ | VKVDQATLTH | YRSDKERAEK | IELRVHESLK | RISCIRSKVE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ELDQEITETA | RLQDELFKST | EEYEQQMITI | RHLESQSDII | NTTINDLKSQ | MTITDESSED |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEKLHSNFAE | KVKEEQELYK | SLEKKRSDLE | SLLKSRRELL | EKLTGDLGKI | QGEIESLEKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVKKSTMINE | IVHRYNINEI | NEEGIMTEVS | KYASLVNKNY | EISSGKLKER | QVAVRARIEG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IKAHEMFLNN | RVSEINSSLE | KQLTTQKELR | SRFEILFPVK | LQREDFTKDV | EKSDLWIKSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RQEYESKNLL | ELLDKHQTAL | SSVENRLDEI | SEIVDSYHKY | SGVRTKLQVF | EENKTNKSAI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LANQLMTLKS | SFSEVMSYEL | KDDDNYNEEL | DKLVEDVRKK | LQEKEEAESS | LRSVRERLEI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RISLSVQSIN | DLTENKKIKT | KTLKSYSGTF | ASMISEIKAL | ESEIEENRKT | LHSLQFGSTF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YEKAIEICVD | QHACQLCQRS | LDKEEEKLFV | EHCHSMIDVI | PSKSAEVYSH | LETLTKTFKN |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LSEAKPIFDE | IELLDKRLSE | TKTELSDLQG | DLQGLDIRKD | EIQSELDTLY | LRRANLEKLQ |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LLVKDISNLE | EEIRTIDRET | EVLRIELPSS | IAHHNLDEIY | AEREKLLEKR | GYLRKQIERT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| KLEETSFKKK | IDDAVLANNE | QKLKLTKLNF | QVNELEQLEK | DINKSSEDCD | LQKKKLLEVS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SKQGSQAPFL | NELESEYEKL | EADIQEMAQK | SRTEILEANE | YLHQLNEWNS | ELRIDVSTKF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KCIKEKKSNI | GEEVRIIASK | IESTDDNLRK | LQERLADLRT | RERNASDNLR | LRALMRQLEE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AVTQKNYLLS | QQSHDDRESF | RERMQILKSK | YGALNAERAG | LLGECKQLEN | SITKDKEELN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| MEFKDADERF | RRQLIKTKTT | GKANEDLGKY | AKALDVAIMQ | LHSMKMNEIN | RIVDELWKQT |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YCGTDIDTIL | IRSDSEGKGN | RTYNYRVCMV | KGDAELDMRG | RCSAGQKVLA | CIIIRLALAE |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| CLGVNCGILA | LDEPTTNLDE | ENICSLAKNL | SRIVEFRRKQ | ANFQLIVITH | DEQFIRLVNS |
| 1270 | 1280 | ||||
| DAYCSYYYRV | KRDTNQKSMI | VKEPL |