Q9UTH3

PR
Gene name
ppk6 (SPAC1805.01c, SPAPJ736.02c)
Protein name
Serine/threonine-protein kinase ppk6
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-170 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

653-674 (Activation loop from InterPro)

Target domain

503-758 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9UTH3

Entry ID Method Resolution Chain Position Source
AF-Q9UTH3-F1 Predicted AlphaFoldDB

12 variants for Q9UTH3

Variant ID(s) Position Change Description Diseaes Association Provenance
I_2772803_G_T 90 S>Y No Jeffares_SNPs
I_2772776_G_A 99 A>V No Jeffares_SNPs
I_2772762_C_T 104 V>I No Jeffares_SNPs
I_2772294_T_C 260 I>V No Jeffares_SNPs
I_2772126_T_C 316 K>E No Jeffares_SNPs
I_2771982_T_C 364 I>V No Jeffares_SNPs
I_2771825_T_C 416 D>G No Jeffares_SNPs
I_2771663_A_G 470 V>A No Jeffares_SNPs
I_2771613_C_A 487 D>Y No Jeffares_SNPs
I_2771517_G_C 519 L>V No Jeffares_SNPs
I_2771252_G_A 607 S>L No Jeffares_SNPs
I_2770779_C_A 751 E>D No Jeffares_SNPs

No associated diseases with Q9UTH3

5 regional properties for Q9UTH3

Type Name Position InterPro Accession
domain PAS domain 157 - 209 IPR000014-1
domain PAS domain 329 - 372 IPR000014-2
domain Protein kinase domain 503 - 758 IPR000719
active_site Serine/threonine-protein kinase, active site 632 - 644 IPR008271
binding_site Protein kinase, ATP binding site 509 - 533 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of establishment or maintenance of cell polarity Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQDVFKHLT SKQVQRTRAR SFGASFERPL ASFLPKKENK NLLSNAARVK LLTFSSSSPY
70 80 90 100 110 120
SFSYSPVLSR DANDGYIPLD TSSRANLWES VTDYDLQHAN EPLVGNYYIS TEALGDGLNR
130 140 150 160 170 180
SPFTINPEKR RSLSDISYVP IPHKEHSNWP VHCSSQAIVT TSNTTFSIWS ANDYFCLLFG
190 200 210 220 230 240
YAGSQLNRHS VFDIFPKSFS SHLSNLIVSF PIDNEHERIL FCGDVFPVIT VDGVRLMDFW
250 260 270 280 290 300
VKEKQGKLIW ILEFVEESYI DIKLQDGVAV DERTEQPLTS DLLPSRLPKT WDQRLYLTTK
310 320 330 340 350 360
TTEGYYCPSM IYPLSKSSFQ YIIFHYAAGL LFINSDFKII SLNEALFESM LGYSDLLTKD
370 380 390 400 410 420
ISLIFPDFKL VLQQLADSHA LDPGRVVSEI HVRHAYRTCT ADKMKKADYP YLIHSDGNII
430 440 450 460 470 480
QIDCQIISVS PHSVKSNEPA FGVWLIFDSV DNRASDFVRS MRSSVILEEV VISDESEEEE
490 500 510 520 530 540
DLSADEDYVD SEWEVVPHNI ASYTTIKELG IGAYGQVKLA TYKSNKVHEV ILKSISKSRI
550 560 570 580 590 600
LLDSWMRDKD LGTVPMEISI LHFLKAHSHP NIVKMITFFE DNENYYLLTE PQKPGIDLFD
610 620 630 640 650 660
YIELKPSISE KESKAIFFQI ALAVAHLHSF DIIHRDIKDE NVILEGNGCA RLIDFGSSSL
670 680 690 700 710 720
TKNGPFDTFR GTVGFAAPEL LRGEKYLGKE QDIWALGILL YTIVYRENPY YNIEEILDAK
730 740 750 760 770
LRIPFELSKD NVDLICRMLD RNVHDRITIE ETLQHHWFDD IRYLDTSHIR IPLSS