Q9UT76

PR
Gene name
tif222 (SPAC343.14c)
Protein name
Probable translation initiation factor eIF-2B subunit beta
Names
eIF-2B GDP-GTP exchange factor subunit beta
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC343.14c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for Q9UT76

Entry ID Method Resolution Chain Position Source
5B04 X-ray 299 A C/D 1-393 PDB
6JLY X-ray 350 A C/D 1-393 PDB
6JLZ X-ray 335 A C/D 1-393 PDB
AF-Q9UT76-F1 Predicted AlphaFoldDB

1 variants for Q9UT76

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1673451_G_C 69 Q>E No Jeffares_SNPs

No associated diseases with Q9UT76

No regional properties for Q9UT76

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9UT76

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTINVEHTY PAVSSLIADL KSRKVQGPFA VAVETALVMR QVISQTRWST VDQLIDTVRA
70 80 90 100 110 120
VGSTLVKAQP TEFSCGNIIR RILRLIREEY QELLKTADEN EKLIVSSSNS SSPSQKRDIP
130 140 150 160 170 180
SNEKLVQSHE PVSVQMYSSM LNLLGRPTLE SPTHSKTVGD SRVTGGMDMR AVIISGIQDV
190 200 210 220 230 240
IDELDKINTD IEVQSMDHLH SNEIILTQGC SKTVEAFLRF AAKKRKFSVI VAEGFPNNQK
250 260 270 280 290 300
GSHAMAKRLA QAGIDTTVIS DATIFAIMSR VNKVILGTHA ILGNGGLVTY SGAQLVAQAA
310 320 330 340 350 360
RHHATPVVVC SGIYKLSPVY PYDLESIIQL SSPDKIMSFN EGDLISRAEI LNPYYDYIPP
370 380 390
DLVDLFITNL GGYPPSYLYR IMNDTYDASD TIL