Q9UT18

PR
Gene name
thi9 (SPAC9.10)
Protein name
Thiamine transporter thi9
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC9.10
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9UT18

Entry ID Method Resolution Chain Position Source
AF-Q9UT18-F1 Predicted AlphaFoldDB

8 variants for Q9UT18

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1482918_C_T 29 P>S No Jeffares_SNPs
I_1482924_C_T 31 L>F No Jeffares_SNPs
I_1482942_G_A 37 D>N No Jeffares_SNPs
I_1483008_A_C 59 N>H No Jeffares_SNPs
I_1483366_T_C 178 I>T No Jeffares_SNPs
I_1483489_T_C 219 V>A No Jeffares_SNPs
I_1483491_T_C 220 F>L No Jeffares_SNPs
I_1484037_G_A 402 V>I No Jeffares_SNPs

No associated diseases with Q9UT18

No regional properties for Q9UT18

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9UT18

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane; Multi-pass membrane protein
  • Cell membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
medial membrane band A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip.

1 GO annotations of molecular function

Name Definition
high-affinity thiamine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.

2 GO annotations of biological process

Name Definition
amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
thiamine import across plasma membrane The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSSQISHQD PELGQTSSGS SSIKEKAEPQ LYAGPIDPAR RPDVFQEGFE DVSVTDDDND
70 80 90 100 110 120
NELLRKMGYQ PVLHRSFEFF ESFAASFASL DVVSGVRLTF SWGISFGGPA AYWSAMLVTG
130 140 150 160 170 180
FCSIVTAACL AEICSALPAA GSIYLWAAES AGPRFGRFVS FLVAWWSTTA WTTFVASITQ
190 200 210 220 230 240
STANFIFAEV STFNNPWPTN DSDVKFRAVQ WIVAEVLLVF TILLNQVPPR YYKWIFKASM
250 260 270 280 290 300
LLMFIDYVMN IIWVPVATSK KPDGFRSAKW VFTETIYDQA GYIKEVDDAN GNPIASLSKI
310 320 330 340 350 360
VPKGWQWCLS YFATAGVIVG YDASGHIAEE TKDASIKAAR GIFYSTVTSF IVAFSLAILY
370 380 390 400 410 420
LFCCPDLDTF TAILYNDNSP QPFVNFYSYL LGRGGHVVMN VVIILEIFLN GVVSVLACSR
430 440 450 460 470 480
LVFAVSRDGV LPFSNWISQV SKTGQPKNAI TVIYIVSALL LCTILPSAVA FTSLVSAAGA
490 500 510 520 530 540
PSFAAYAVLA FCRLFITRDK FPKGRWSLGW LSKPCLVITL VYNLFALVVN VSPYTYPVTG
550 560 570 580 590
PSFNYAVVIM GGVSIFAIIC TIVIPKSRWV ANRYRYESDS EHSASVKELK V