Q9USY2
Gene name |
SPBC1861.04c |
Protein name |
Uncharacterized RNA-binding protein C1861.04c |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC1861.04c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9USY2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9USY2-F1 | Predicted | AlphaFoldDB |
No variants for Q9USY2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9USY2 | |||||
No associated diseases with Q9USY2
8 regional properties for Q9USY2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 1 - 74 | IPR000504 |
| repeat | Pumilio RNA-binding repeat | 191 - 228 | IPR001313-1 |
| repeat | Pumilio RNA-binding repeat | 227 - 264 | IPR001313-2 |
| repeat | Pumilio RNA-binding repeat | 264 - 298 | IPR001313-3 |
| repeat | Pumilio RNA-binding repeat | 299 - 335 | IPR001313-4 |
| repeat | Pumilio RNA-binding repeat | 374 - 410 | IPR001313-5 |
| domain | Pumilio homology domain | 129 - 482 | IPR033133 |
| domain | Npl3, RNA recognition motif 1 | 1 - 71 | IPR034166 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| U6 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| snRNA binding | Binding to a small nuclear RNA (snRNA). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spliceosomal complex assembly | The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. |
| spliceosomal tri-snRNP complex assembly | The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQIQDLKDE | NVEMDIDPQE | QNEKKPLLLD | ELTKFTILHP | YNYDSHIKLI | EELKRLDKKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELSEARKTFQ | SIFPLSEDLW | VDYLLDECKN | CRTLDDYVRI | KTLFDLAVQD | YLSIKIWCMY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEFTLNLMDT | SSFEQEQSEL | NGVITLTDAH | SLFERAYQTC | KFHFSKSQCV | WTLYLEFLQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FGDALFEGEE | EQEIVFKNKI | YDFHIDRLKL | PHEQIEETFT | SLSTFVTNNW | SPSEYEDVMV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KSNKVYETTL | KRNAKIFNKE | LLLNSANHSL | EAYMDLINDE | SRRSTAELQY | ITTLYERAIV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LYPLIPELWL | QYTAWLSKVD | FSSSQASSVA | ERATRNCSWI | GRIWSIKLTY | MTLSGASTSA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VCEEKDRCLN | SNLLVNFDEV | IDFFSGFLKA | CLYLSSNEDK | PQEFLKHQIH | KVEDYLRKNH |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KGSKDARMRI | ELSKIYLYSE | ISDFESVEKC | WSDMFHDFQN | QALYWISRYI | STMKYNPELA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AETLKKSLYK | NVDQPQLLFQ | FYQSIMDLNN | DCFTNTSHLY | DVLNAQRISF | KRQLDSFAEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TKQTVENTEP | LKVPQADDTA | ALSKKRKPGQ | EGDVFKKSKP | IEQHRNREEL | TVLVTNLPSD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ISENELKIFF | KDCGNIIRIF | ILEDNQKDVK | VAQIEFSETS | EVLAAKTRDL | KSIRGHEISV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QIHVDTNLYV | TNFPPTYDEL | DITKLFSAYG | NVVDVRFPSL | RYNTNRRFCY | VQMRKPDEAH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NALQLHKKLL | EEKYPIQVFI | SDPLRRTPRS | GAVYEGRELY | VTNIDFKVNE | KDVETFFRDY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GQVESVRIPK | RFNQHKGFGY | VVMTTNQDAE | NALSAAGKQL | GNRVLNVVLS | KPRESLEKTR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VSSNDNRTLA | KSFETTESNK | MSTPKKSFEQ | IKSKSLGVTN | VDGTVNEARL | RSLFESYGKL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| YRVVLHPEHE | GAVVEFLDIH | DAGKASLALE | GHEIGGRLLH | ITTVNEMMHN | VPSSMNHSDY |
| 970 | 980 | 990 | 1000 | 1010 | |
| NTSATRPRRL | GSRTFQGFNS | NHSNINSKKD | DLDDKEMQID | APKSNDDFRK | MFLK |