Q9USX1

PR
Gene name
ape1 (SPBC1921.05)
Protein name
Aminopeptidase 1
Names
Aminopeptidase I
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC1921.05
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9USX1

Entry ID Method Resolution Chain Position Source
AF-Q9USX1-F1 Predicted AlphaFoldDB

No variants for Q9USX1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9USX1

No associated diseases with Q9USX1

3 regional properties for Q9USX1

Type Name Position InterPro Accession
domain Peptidase M1, membrane alanine aminopeptidase 245 - 461 IPR014782
domain ERAP1-like C-terminal domain 541 - 859 IPR024571
domain Aminopeptidase N-like, N-terminal domain 25 - 206 IPR045357

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal-type vacuole lumen The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.
multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
NVT complex A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1.

3 GO annotations of molecular function

Name Definition
metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.
zinc ion binding Binding to a zinc ion (Zn).

4 GO annotations of biological process

Name Definition
cytoplasm to vacuole transport by the NVT pathway A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe.
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQVTIPKSTS KEDDKNRNLL PKNVKPIHYD LSLYPDLETF TYGGKVVVTL DVLEDSNSIT
70 80 90 100 110 120
LHGINLRILT AALEWGSQTV WASEVSYGDE RIVLQFPSTV PANSVAVLTL PFTARISSGM
130 140 150 160 170 180
EGFYRSSYVD SDGNTKYLAT TQMEPTSARR AFPCWDEPAL KATFTIDITA KENYTILSNM
190 200 210 220 230 240
NAVEETVKDG LKTARFAETC RMSTYLLAWI VAELEYVEYF TPGKHCPRLP VRVYTTPGFS
250 260 270 280 290 300
EQGKFAAELG AKTLDFFSGV FGEPYPLPKC DMVAIPDFEA GAMENWGLVT YRLAAILVSE
310 320 330 340 350 360
DSAATVIERV AEVVQHELAH QWFGNLVTMQ FWDGLWLNEG FATWMSWFSC NHFYPEWKVW
370 380 390 400 410 420
ESYVTDNLQS ALSLDALRSS HPIEVPIMHD YEINQIFDAI SYSKGSCVIR MVSKYVGEDT
430 440 450 460 470 480
FIKGIQKYIS KHRYGNTVTE DLWAALSAES GQDISSTMHN WTKKTGYPVL SVSETNDGEL
490 500 510 520 530 540
LIEQHRFLST GDVKPEEDTV IYWAPLKLKT MKDGKAVVDE KAVLSDRSKK IKVDKEALES
550 560 570 580 590 600
YKLNSEQSGI YRVNYSADHL KKLSQIAVEK PDYLSVEDRA GLIADVASLS RAGYGKVSST
610 620 630 640 650 660
LDLIKTWKDE PNFVVFAEML ARLNGIKSTL RFESSDIIAA MKKLVLEVSA TKAHSLGWEF
670 680 690 700 710 720
KANDDHIIRQ FKSTVYNYAG LFGDDKVVKD ALSKFDAYAS GNKSAINDNL RSAVFNIAIR
730 740 750 760 770 780
YGGAKSWDQL LEIYTKTNDP YVRNSCLRAF GVTEDEKYIQ KTLDLTLDPI VKEQDIYLIL
790 800 810 820 830 840
VTLSTHKNGV LAMWKFATSN WDKLLSRLPV AGTMRGYVVR FVTSGFTHAS AIDKIKEFFA
850 860 870 880
DKDTKLYERA LQQSLDTISA NSSFIDKSLD DITRWLKENR YM