Q9USU2

PR
Gene name
dim1 (SPBC336.02)
Protein name
Dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, 18S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC336.02
EC number
2.1.1.183: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-42 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9USU2

Entry ID Method Resolution Chain Position Source
AF-Q9USU2-F1 Predicted AlphaFoldDB

No variants for Q9USU2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9USU2

No associated diseases with Q9USU2

2 regional properties for Q9USU2

Type Name Position InterPro Accession
conserved_site Ribosomal RNA adenine methylase transferase, conserved site 54 - 81 IPR020596
domain Ribosomal RNA adenine methylase transferase, N-terminal 38 - 207 IPR020598

Functions

Description
EC Number 2.1.1.183 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor.

2 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKIRVRNNN AASDAEVRNT VFKFNKDFGQ HILKNPLVAQ GIVDKADLKQ SDTVLEVGPG
70 80 90 100 110 120
TGNLTVRMLE KARKVIAVEM DPRMAAEITK RVQGTPKEKK LQVVLGDVIK TDLPYFDVCV
130 140 150 160 170 180
SNTPYQISSP LVFKLLQQRP APRAAILMFQ REFALRLVAR PGDPLYCRLS ANVQMWAHVK
190 200 210 220 230 240
HIMKVGKNNF RPPPLVESSV VRIEPKNPPP PLAFEEWDGL LRIVFLRKNK TIGACFKTSS
250 260 270 280 290 300
IIEMVENNYR TWCSQNERMV EEDFDVKSLI DGVLQQCNLQ DARASKCGQT EFLSLLHAFH
QVGVHFA