Q9USR3
PR
Gene name |
stt4 (SPBC577.06c) |
Protein name |
Phosphatidylinositol 4-kinase stt4 |
Names |
PI4-kinase, PtdIns-4-kinase |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPBC577.06c |
EC number |
2.7.1.67: Phosphotransferases with an alcohol group as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9USR3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9USR3-F1 | Predicted | AlphaFoldDB |
No variants for Q9USR3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9USR3 | |||||
No associated diseases with Q9USR3
5 regional properties for Q9USR3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | 1593 - 1874 | IPR000403 |
| domain | Phosphoinositide 3-kinase, accessory (PIK) domain | 1260 - 1505 | IPR001263 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 1623 - 1637 | IPR018936-1 |
| conserved_site | Phosphatidylinositol 3/4-kinase, conserved site | 1716 - 1736 | IPR018936-2 |
| domain | PI4-kinase, N-terminal | 1013 - 1245 | IPR045495 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.1.67 | Phosphotransferases with an alcohol group as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol 4-kinase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphatidylinositol kinase activity | Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylethanolamine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| phosphatidylinositol phosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDCIDKSIRR | ESLRKLGCLP | DHGWNLFVQS | SNRYSKLLEA | DSKLFKAQRI | EDTVLSICEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TLENKASENA | LTLFQQLRFY | LLNYLFLEDT | SEYKSVLCSL | DESVYPNLLP | LTANICPCIL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KALLALVRQH | RELSSDIVKF | LNSIFLALTR | ILNTPHSSNN | NPTHTKTTIF | EKVFYASHLG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FFFEEIADAC | ISALPQDACL | WAMEVCNTIL | VSDLPCKLID | LHNDSFLHHS | NYYAGFGLSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLYLSSMKAY | INSSGCLWYE | DATSFWDIVK | HRPSSPEEKP | FLTQFQSILN | LSDKFLSKTG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TLRLQEKLGT | SCNLFFVLVL | KLALLSSSYI | GFVPYTYSDW | INVLLGSISE | DPELLPHLIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LMASLACVFP | THFQFAMKRL | RLIAIYAPRF | DDGNVTYAQL | ASRKLAQLFN | YSSRDTAITS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IYQFANLLSP | ADTPDSYLAA | PKERLSISDN | MSSSSSQTAT | VNTISNYLNV | IDSVREIALT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNDEKIYGLA | ISLLIQKFSR | KFDSRVSTEL | VRTLADISTK | ANDRDFSILV | QFYSIQNKML |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VKNGDEALTI | AICDSRCLIA | RGTESNSFKR | SDLLKSLLEE | IIHIGIVRDT | PAPELKGYYF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GMSKAVQALV | ECVAGTDWSS | LPKEEMYPAL | FRDMWFTLVI | NRFRYSVDLG | ETLEVDLENI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AKNSPLLVFE | DFGSNFESNL | ELNTVLRTHI | EHSVISQIKS | ELLVRVPNID | LKPLSTSEIC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FLSAVLLLES | LRCKSNKLSA | LVEYLLDPSL | RDSQLPQSIR | AIALYNLTSF | VESLSKERRV |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ASSTIDEFQK | LLCLCCNRVD | CVRQLALECM | NYIMETLPHL | LGIKEILFSV | LELSSLLWKA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RTEECTDQYV | PQLLYKSNKL | NLSVILSDIY | SCREEVLFQF | NRHARSWIQN | SSKAIPYQVK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NLLESYLADF | VDFDDLEVVE | LGRSLAVELG | TRIVSSDRDN | FVLPAFGNWT | PDTSSEFMAE |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| YTIRQRYSHV | DNSILNIEGD | MSTDRIDLIL | NEKSKLFETH | LAALKSLEDD | ILQGNTVSPQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RLRNEVRKAA | AHAVQEPIFQ | FSVLARKIVR | IPFLDFSPSS | FKLGITLWNW | MMNQVPSFSS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FLISNIIRNW | KNEIVTEKRG | YFSTAKSKSP | LALPMTYSPT | ERASFLSYKN | KVMSQMIPHL |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LLLQLIAGNF | EGFWYGDRQT | AKLIVHFMKF | VLKKITSMEV | NLNVLTRELH | FKFVSFGLRI |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| AENLLNSPLG | SRFYNLCVDA | GLCWFSGMPN | WTYGADKLHV | AAEISVMRSL | RDKLDSFLLR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| YPLKVSTTLK | QKLLIILLNN | EMYMLYTWLT | PVLHGRNVRM | VEPIPDSDAA | SSPITLEMLQ |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| VAWNVSPNIV | LYAPKRFQNA | PLKQMALNFV | IANPFTSVKH | EVALEYLFEH | YPSGEFPIDR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| KFILYWEPMY | PVSGPVMFMP | NVKWNPQLLQ | YTMRSMESYP | VSVTFFYVPQ | IVQSLRYDSM |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| GYAESFILET | SGTSQLFAHQ | ILWNMKANLY | KDEAATVPDS | IKPILDRVMD | KMINSLSGED |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KQFYEREFTF | FNEVTSISGK | LKPFIRKSKP | EKKAKIDEEM | KKIKLDVGVY | LPSNPDGVIV |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| GIDRKSGKPL | QSHAKAPFMA | TFKIRKEKLV | DADPEELAVN | GTEEEAGDSA | KKQTYEVWQS |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| AIFKVGDDCR | QDVLTLQLIA | MFKNIFNSVG | LDVYLFPYRV | TATNPGCGVI | DVLPNCISRD |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| MLGREAVNGL | YDYFRTKFGD | EDSIAFQKAR | SNFVQSMAAY | SVITYLLQFK | DRHNGNIMID |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| DQGHILHIDF | GFIFDIAPGG | ITFESAPFKL | TTEMIAVMGG | SNKSQPFQWF | QELCVKAFLA |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| CRPYAHYICQ | AVEVMLDSGL | PCFKGQLTIT | HCLERFALNL | NERQASTFML | HLIEQSYANK |
| 1870 | |||||
| RTLMYDQFQK | ATNGIPY |