Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9USQ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9USQ2-F1 | Predicted | AlphaFoldDB |
No variants for Q9USQ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9USQ2 | |||||
No associated diseases with Q9USQ2
11 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| equatorial microtubule organizing center | A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. |
| gamma-tubulin complex | A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. |
| half bridge of mitotic spindle pole body | Structure adjacent to the plaques of the mitotic spindle pole body. |
| inner plaque of mitotic spindle pole body | One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| mitotic spindle pole body | The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| old mitotic spindle pole body | The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| establishment or maintenance of cell polarity regulating cell shape | Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| microtubule nucleation | The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic spindle assembly | Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. |
| spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEIHVKTAL | SRLADKYLQN | SKNPSVPYTI | ETIVSFFQEI | IHSISPDTFQ | LDIDDILYKI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YSKIPPEENN | DALFSKLSNL | VSRLKSQTVI | HNKSQILYFL | YLLSPISQSS | RDVSSHLLDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SISNPINIPS | TEVESSNFGQ | TRYDQVPENP | QITDWDEGLE | NESSISIAHD | SSRLNRSTET |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSVQHTLITE | ADLLSSISYV | LQGISTEYVQ | FKNELALLSK | RIPVQYLLQM | RALSETGLLY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QELKVFSNYD | PSVSQSIDGD | NVSKAFINDQ | SLALQSLKSV | ISKELTNFLA | LIASLDSQIR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ADASLEKPMV | TIRRCIAWTQ | VAKLKLRILS | SVVNDNMNQE | NKKRLIQVVS | KYNVHGDPLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QELSDKILTE | ITGPLYEMIE | NWIYKGELVD | PYQEFFVKEK | NGSESHDHQG | QGDVVWKGKY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FLDKELIPSF | LSEELVDKIF | LIGKSLNFAR | YGCGDFDWAQ | EHYQKLVKKL | SYRDPHSLET |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VVDKAYTESI | NHLVYLMEEV | FHLTDHLKAI | KKYLLLGQGD | FVDLLMESLG | NSLDQPANTL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FRHNLTASLE | SAIRSSNASY | EPEYVLKRLD | ARLLELSHGE | TGWDVFTLEY | KVDSPINVII |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TPYCSRQYLK | IFNFLWRLKR | IEFALAHSWR | RVNLGERNVF | RNLDYTKFEW | HFVSCHLAEM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IHFVCQLQYY | ILFEVIEISW | QELQLAMEKP | NATLDTYIEA | HEKYVTSITH | KGLLGGGKSR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NEDSFLHQLH | DILKVILNFH | DAIELLYNFS | CSLSNRIRIN | VPISTDALAA | QYTPIKNELS |
| 790 | 800 | 810 | 820 | 830 | |
| NFTEEFQVRL | QKLLHGLASH | KDPEMRFLSV | RLNYNEFYVS | HRRRHDKDVT | SQ |