Q9USN5

PR
Gene name
gdh2 (SPCC132.04c)
Protein name
Probable NAD-specific glutamate dehydrogenase
Names
NAD-GDH
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC132.04c
EC number
1.4.1.2: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

32-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9USN5

Entry ID Method Resolution Chain Position Source
AF-Q9USN5-F1 Predicted AlphaFoldDB

No variants for Q9USN5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9USN5

No associated diseases with Q9USN5

1 regional properties for Q9USN5

Type Name Position InterPro Accession
domain Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal 739 - 1003 IPR006096

Functions

Description
EC Number 1.4.1.2 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
glutamate dehydrogenase (NAD+) activity Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.

2 GO annotations of biological process

Name Definition
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.
glutamate catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYLTKQIPHY SRIHTTQLLT VVNHRTIPFK IRGSFSNCRR YSNFATVPLL ERPFKNKSKH
70 80 90 100 110 120
NTARASRPFS TQKMLLTKSH PPNMYKDSVF FGYRPIVFSG KQDQKSKVIQ CLRTERKTIP
130 140 150 160 170 180
DDLVEDEVDR FYNKLGLDDY YFQMEPVSII ADHIEIIYAA KIAAHASHAK EELNIHVKNE
190 200 210 220 230 240
NEDLAIYLDS SPVTQPELDQ SSAVEESIST RYLDPFKLTD PTAYRVESFT SVTNIDRTST
250 260 270 280 290 300
ENSNIYTYFV TKCDFVDNPK KDASPDVPTD IASVSDKTFL EKASDNTIEM YQDVMNSVLT
310 320 330 340 350 360
RFGPVVRLFD YQGRSEIRLV VGYRRGSIFQ YFPSLSKLFR YYGLHSTRTY VEQFSNGVTI
370 380 390 400 410 420
ISYNFKPELF KNAAVTSINE LFSQITREAS LLYCLPSTDF QPLFVSEKLS IQEVTYAHCV
430 440 450 460 470 480
RIFCEHVMNK LGPEYSSLSA ILDHSNNIHA EILETIKRRL STLAFTRTKI HDTIMQYPGL
490 500 510 520 530 540
VHTLFEQFYL EHAINHNSTP HLHRAKSATS LADEASTYSI TPMSATALMD LIQKTCTNEE
550 560 570 580 590 600
DVSVMEMFVK FNTHLLKTNF FQTTKVALSF RFDPSFLDST QYKDPLYAMI MSIGNEFRGF
610 620 630 640 650 660
HLRFRDVARG GIRLIKSANP EAFGLNARGL FDENYNLAKT QMLKNKDIPE GGAKGVILLG
670 680 690 700 710 720
KDCQDKPELA FMKYIDSIID LLIVNKSQPL VDKLGKPEIL FMGPDENTAD LVNWATIHAH
730 740 750 760 770 780
RRNAPWWKSF FTGKKPTMGG IPHDKYGMTS LSVRCYVEGI YKKLNITDPS KLTKVQTGGP
790 800 810 820 830 840
DGDLGSNEIK LSNEKYIAVI DGSGVLYDPA GLDRTELLRL ADERKTIDHF DAGKLSPEGY
850 860 870 880 890 900
RVLVKDTNLK LPNGEIVRNG TIFRNTAHLR YKADTFVPCG GRPNAININN VEQLIDDHGR
910 920 930 940 950 960
PAFKYLVEGA NLFITQDAKS VLEKAGVIVI RDASANKGGV TSSSLEVLAS LSFDDASFKE
970 980 990 1000 1010 1020
NMCVHDGKVP TFYADYVNEV KRIIQRNANL EFEAIWKGHS ENKIPYTSLS NHLSTEIVKL
1030 1040 1050 1060 1070 1080
DHDIYNYEKL WADVGFRNAV LRASIPKTLQ AKIGLEKMLE RIPESYLRAI FSTYLASRFV
1090 1100
YQHVVSSDPF AFFDYISTEM KMLKDA