Q9USN1

PR
Gene name
snx12 (SPCC16A11.04)
Protein name
Sorting nexin-12
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC16A11.04
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

254-335 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9USN1

Entry ID Method Resolution Chain Position Source
AF-Q9USN1-F1 Predicted AlphaFoldDB

No variants for Q9USN1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9USN1

No associated diseases with Q9USN1

3 regional properties for Q9USN1

Type Name Position InterPro Accession
domain Phox homology 695 - 815 IPR001683
domain Phox-associated domain 88 - 275 IPR003114
domain RGS domain 390 - 529 IPR016137

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum-vacuole membrane contact site A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleus-vacuole junction An organelle membrane contact site formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p.
vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

2 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
vacuole-ER tethering The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYQQHIFYFI TGGIFILWIL AHSFFVKIIY LWASGCLLWY CLETRTFENK NNLGTSEPFL
70 80 90 100 110 120
VNPAIFQKRA RQLALSKLLL RQPLYPGIPE ISEEIESIIS HFMQKYIKVW SYQIIPEPTI
130 140 150 160 170 180
SNSIESHLRK CLMVLLSRVD EIDLADVLVK TVLPLITKHL RLFVEAEQLV VGNKAVSFTD
190 200 210 220 230 240
HSELSREVAA KYDHGRLHEA VLLSGNPMVA QKRYLRNWTT QVLSIILPNY YETSPLVLSL
250 260 270 280 290 300
VTEVIINTTL LPLVSYISDP DFFNYLIIQA SGSIIQRRRK IRRLKRAIRK QSNHFQVGAR
310 320 330 340 350 360
RLRLKDSQHS FEQYIHEIKK ISNISDARRL RSELMVQRRQ LEQTEAFDFE FKQYRERLQI
370 380 390 400 410 420
AIITAEKRIS LLSGTPFQHK EAVLFEQVQS LLQILSDSAA VSCFLEFMER KNRSRYLHFW
430 440 450 460 470 480
LVVEGLKESQ DDPLNAHMIA PFSDIVSDHT DFTAIVKSYF ESVDNPLDIP KPLTNTINKF
490 500 510 520 530 540
VNQSKDNLNP DLWVEARNAM LMAQEHVFDI MQNSDYSEFV NSEIYYRFLA QDVVSDHKST
550 560 570 580 590 600
NSSATFSRLE ELGENIPAIS KQPSYLSISS SSKSINSSPS PSIQLSVSSS ISRDKNLSPL
610 620 630 640 650 660
DLELDDPTYS DEEEVLFAPP GDLQLSESID ELNNNIEELK AQLNAINTLI KKAELVADQK
670 680 690 700 710 720
QLKSLTKNHQ EIEKAIHRKE RQRDQYMSQE EDSKLFNRSR VSIDSFKISK EENTPDFAVY
730 740 750 760 770 780
TIRIERLENG HVRSGWMVAR RYREFAELHK QLKQTYPGVR SLKFPQKSII TSLNKNVLEY
790 800 810 820 830 840
RRGALEEYLQ SLFRMPEVCD SKMLRMFLSQ QNITAPQMFN PKEVGKKWKQ LLEVLGFEVN
850 860 870 880 890 900
NSFNASNVNT NSSFSGPISE FLVELFSPND DAKQQWLPKK TYISILEQLF GGALEKRIRL
910 920 930 940 950 960
QLFQLFTPEK IYRKLREFRR GLEGKSNHDH SKDRRHSRAR KPAYADRNQL KAEAGILLAS
970 980 990 1000
MFPGYTPDIA VKRIFRILQN QSLNAHVIYT LLDEILLALK KHARSTNKAT