Q9UN81

PR
Gene name
L1RE1 (LRE1)
Protein name
LINE-1 retrotransposable element ORF1 protein
Names
L1ORF1p, LINE retrotransposable element 1, LINE1 retrotransposable element 1
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-58 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for Q9UN81

Entry ID Method Resolution Chain Position Source
2LDY NMR - A 157-330 PDB
2W7A X-ray 140 A A/B 157-250 PDB
2YKO X-ray 210 A A/B/C 106-330 PDB
2YKP X-ray 310 A A/B/C 106-326 PDB
2YKQ X-ray 310 A A/B/C 106-326 PDB
6FIA X-ray 265 A A/B/C/D/E/F 53-152 PDB
AF-Q9UN81-F1 Predicted AlphaFoldDB

No variants for Q9UN81

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9UN81

No associated diseases with Q9UN81

3 regional properties for Q9UN81

Type Name Position InterPro Accession
domain L1 transposable element, dsRBD-like domain 255 - 319 IPR035300
domain L1 transposable element, trimerization domain 110 - 152 IPR035301
domain L1 transposable element, RRM domain 155 - 252 IPR043636

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Cytoplasm
  • Cytoplasm, Cytoplasmic ribonucleoprotein granule
  • Cytoplasm, Stress granule
  • Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655)
  • Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic ribonucleoprotein granule A ribonucleoprotein granule located in the cytoplasm.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

4 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
single-stranded DNA binding Binding to single-stranded DNA.
single-stranded RNA binding Binding to single-stranded RNA.

1 GO annotations of biological process

Name Definition
transposition, RNA-mediated Any process involved in a type of transpositional recombination which occurs via an RNA intermediate.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5T7N2 L1TD1 LINE-1 type transposase domain-containing protein 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MGKKQNRKTG NSKTQSASPP PKERSSSPAT EQSWMENDFD ELREEGFRRS NYSELREDIQ
70 80 90 100 110 120
TKGKEVENFE KNLEECITRI TNTEKCLKEL MELKTKAREL REECRSLRSR CDQLEERVSA
130 140 150 160 170 180
MEDEMNEMKR EGKFREKRIK RNEQSLQEIW DYVKRPNLRL IGVPESDVEN GTKLENTLQD
190 200 210 220 230 240
IIQENFPNLA RQANVQIQEI QRTPQRYSSR RATPRHIIVR FTKVEMKEKM LRAAREKGRV
250 260 270 280 290 300
TLKGKPIRLT ADLSAETLQA RREWGPIFNI LKEKNFQPRI SYPAKLSFIS EGEIKYFIDK
310 320 330
QMLRDFVTTR PALKELLKEA LNMERNNRYQ PLQNHAKM