AiPD: Autoinhibited Protein Database

Q9UL54

Gene name	TAOK2 (KIAA0881, MAP3K17, PSK, PSK1)
Protein name	Serine/threonine-protein kinase TAO2
Names	Kinase from chicken homolog C, hKFC-C, Prostate-derived sterile 20-like kinase 1, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Thousand and one amino acid protein kinase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9344
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-478 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

392-478 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

168-187 (Activation loop from InterPro)

Target domain	28-281 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UL54

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UL54-F1	Predicted				AlphaFoldDB

890 variants for Q9UL54

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV000953357 RCV002298806 rs368747234	392	E>missing	Hepatocellular carcinoma [ClinVar]	Yes	ClinVar dbSNP
rs1256997964 CA395469480	4	G>R		No	ClinGen TOPMed
rs755199294 CA7997692	5	G>V		No	ClinGen ExAC gnomAD
CA395469490 rs1242272222	6	R>Q		No	ClinGen TOPMed gnomAD
CA7997693 rs146116179	6	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA7997695 rs755972701	8	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1354458295 CA395469507	9	S>I		No	ClinGen TOPMed
rs748733191 CA7997697	9	S>R		No	ClinGen ExAC gnomAD
rs1432429783 CA395469537	13	P>L		No	ClinGen TOPMed
rs1432429783 CA395469536	13	P>R		No	ClinGen TOPMed
rs1347355481 CA395469538	14	D>N		No	ClinGen TOPMed
TCGA novel	15	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	19	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7997701 rs771869853	21	K>R		No	ClinGen ExAC gnomAD
CA395469631 rs762280762	26	K>N		No	ClinGen ExAC TOPMed
rs777116231 CA7997702	26	K>R		No	ClinGen ExAC gnomAD
CA7997704 rs765662810	27	L>P		No	ClinGen ExAC gnomAD
CA395469653 rs1596595527	30	D>A		No	ClinGen Ensembl
CA7997707 rs766380067	30	D>H		No	ClinGen ExAC TOPMed gnomAD
CA395469665 rs1376172296	32	R>Q		No	ClinGen gnomAD
CA7997708 rs751670508	32	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755146133 CA280430378	33	E>K		No	ClinGen ExAC gnomAD
rs755146133 CA7997709	33	E>Q		No	ClinGen ExAC gnomAD
rs767764424 CA7997710	36	H>R		No	ClinGen ExAC gnomAD
rs1206406398 CA395469728	42	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1306051542 CA395469775	47	D>N		No	ClinGen TOPMed
rs1005177502 CA280430605	48	V>I		No	ClinGen Ensembl
rs752906788 CA7997729	49	R>Q		No	ClinGen ExAC gnomAD
CA395469801 rs1272747555	49	R>W		No	ClinGen gnomAD
rs763906149 CA7997731	50	N>S		No	ClinGen ExAC gnomAD
CA395469812 rs1596596040	50	N>Y		No	ClinGen Ensembl
CA7997734 rs779036453	66	S>P		No	ClinGen ExAC gnomAD
rs966469217 CA280430638	67	N>S		No	ClinGen TOPMed gnomAD
CA7997749 rs764269417	72	D>N		No	ClinGen ExAC gnomAD
CA7997750 rs753635436	77	V>L		No	ClinGen ExAC gnomAD
rs761769256 CA7997751	78	R>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	78	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374212447 CA395470216	78	R>W		No	ClinGen TOPMed
CA7997752 rs765255700	81	Q>R		No	ClinGen ExAC gnomAD
rs750331994 CA7997753	82	K>M		No	ClinGen ExAC gnomAD
CA7997755 rs150712108	84	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395470419 rs1313275626	88	T>I		No	ClinGen TOPMed
TCGA novel	92	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs865791050 CA280430875	92	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7997757 rs754637836	92	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7997760 rs757559465	97	R>K		No	ClinGen ExAC gnomAD
rs1201123116 CA395470591	100	T>R		No	ClinGen gnomAD
CA395470859 rs1283979500	109	L>V		No	ClinGen TOPMed gnomAD
CA395471807 rs1390324284	123	L>F		No	ClinGen gnomAD
TCGA novel	124	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7997802 rs781376740	131	V>L		No	ClinGen ExAC gnomAD
CA395471879 rs1436970368	134	G>R		No	ClinGen gnomAD
TCGA novel	140	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395471960 rs774229445	146	N>S		No	ClinGen ExAC TOPMed gnomAD
CA7997808 rs774229445	146	N>T		No	ClinGen ExAC TOPMed gnomAD
rs1437221463 CA395472048	156	N>K		No	ClinGen TOPMed
rs1349545690 CA395472056	157	I>M		No	ClinGen TOPMed
CA280431467 rs919570391	165	V>A		No	ClinGen Ensembl
rs939417987 CA280431477	175	I>N		No	ClinGen TOPMed
rs768089730 CA7997831	175	I>V		No	ClinGen ExAC gnomAD
rs1181246589 CA395472172	176	M>K		No	ClinGen gnomAD
CA7997832 rs776236834	177	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1473460766 CA395472185	178	P>S		No	ClinGen gnomAD
rs140117945 CA7997833	180	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
COSM969704 COSM969705 CA7997857 rs767951266	192	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1596598662 CA395472338	193	V>G		No	ClinGen Ensembl
rs1377682145 CA395472446	203	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7997861 rs753857036	206	V>A		No	ClinGen ExAC gnomAD
rs375334553 CA7997863	208	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1247516476 CA395472664	215	C>Y		No	ClinGen gnomAD
rs1189534622 CA395472700 COSM969707 COSM969708	217	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA7997908 rs756769478	221	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7997907 rs753383907	221	R>W		No	ClinGen ExAC gnomAD
rs778568429 CA7997909	222	K>Q		No	ClinGen ExAC gnomAD
CA395473784 rs1460827015	222	K>T		No	ClinGen gnomAD
rs865824525 CA280433365	224	P>S		No	ClinGen Ensembl
rs745492252 CA7997910	225	L>H		No	ClinGen ExAC gnomAD
TCGA novel	228	M>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7997912 rs781600192 COSM170218	230	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs773769604 CA7997915	235	Y>H		No	ClinGen ExAC gnomAD
CA395474119 rs1306743411	241	E>D		No	ClinGen Ensembl
rs143934788 CA7997917	243	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1313958114 CA395474152	244	V>M		No	ClinGen TOPMed gnomAD
CA395474210 rs1204412027	247	S>P		No	ClinGen TOPMed
CA395474227 rs1234073466	248	G>R		No	ClinGen TOPMed gnomAD
CA7997920 rs767669894	249	H>R		No	ClinGen ExAC gnomAD
rs778066032 CA7997951 COSM184905	255	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1168058728 CA395474499	258	V>I		No	ClinGen gnomAD
rs142801026 CA7997954	259	D>E		No	ClinGen ESP ExAC gnomAD
CA395474515 rs1458583458	259	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7997956 rs373914698	260	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs373914698 CA7997955	260	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA280433645 rs200074622	263	Q>E		No	ClinGen Ensembl
CA395474641 rs1158759155	265	I>F		No	ClinGen TOPMed
TCGA novel	267	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395474677 rs1298907781	267	Q>R		No	ClinGen gnomAD
rs1167389928 CA395474694	268	D>G		No	ClinGen TOPMed gnomAD
CA280433680 rs970485759	271	T>A		No	ClinGen TOPMed gnomAD
TCGA novel	271	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280433692 rs151026108	274	V>A		No	ClinGen ESP TOPMed
CA395474768 rs1188512114	274	V>I		No	ClinGen TOPMed
rs1480951180 CA395474969	278	H>Q		No	ClinGen TOPMed
TCGA novel	278	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754043273 CA7997976	279	R>C		No	ClinGen ExAC TOPMed gnomAD
COSM393101 rs747127087 COSM393100 CA7997977	279	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA280434389 rs903892697	281	V>L		No	ClinGen Ensembl
rs1000878010 CA280434397	283	R>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA7997978 rs141012429	283	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA395475078 rs1473676019	285	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA280434431 rs569219357	285	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA395475097 rs1273714728	287	P>T		No	ClinGen TOPMed
CA7997980 rs748396259	288	T>A		No	ClinGen ExAC gnomAD
rs149797802 CA395475140	290	I>L		No	ClinGen ESP TOPMed gnomAD
rs149797802 CA280434440	290	I>V		No	ClinGen ESP TOPMed gnomAD
CA395475277 rs1316246258	297	T>I		No	ClinGen TOPMed
TCGA novel	298	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395475294 rs1414787531	299	D>N		No	ClinGen gnomAD
rs1414787531 CA395475296	299	D>Y		No	ClinGen gnomAD
CA7997984 rs770953476	301	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs773843358 CA7997985	303	E>D		No	ClinGen ExAC gnomAD
rs773124521 CA280434462	310	R>C		No	ClinGen gnomAD
rs773124521 CA395475456	310	R>G		No	ClinGen gnomAD
CA395475469 rs1567242800	310	R>L		No	ClinGen Ensembl
rs760462943 CA280434463	314	K>T		No	ClinGen Ensembl
CA395475590 rs898929706	317	F>L		No	ClinGen TOPMed gnomAD
CA395475683 rs575152450	323	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7997987 rs575152450	323	G>S		No	ClinGen 1000Genomes ExAC gnomAD
CA7997988 rs752276045	324	P>L		No	ClinGen ExAC gnomAD
CA395475700 rs1273066702	324	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1483933331 CA395475720	325	G>A		No	ClinGen gnomAD
rs1013425351 CA280434505	327	E>K		No	ClinGen gnomAD
CA395475799 rs1288155236	330	E>A		No	ClinGen gnomAD
rs1232539311 CA395475847	333	E>G		No	ClinGen gnomAD
TCGA novel	334	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745755045 CA7998022	335	A>S		No	ClinGen ExAC gnomAD
CA7998023 rs772044091	335	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7998025 rs368342001	337	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs368342001 CA280394534	337	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1451485192 CA395479153	338	Y>C		No	ClinGen TOPMed
CA7998027 rs776291776	339	M>R		No	ClinGen ExAC gnomAD
CA7998026 rs371958190	339	M>V		No	ClinGen ESP ExAC gnomAD
CA7998028 rs761378241	340	H>Y		No	ClinGen ExAC gnomAD
rs892541929 CA395479205	341	R>G		No	ClinGen gnomAD
CA7998029 rs766814244	341	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA280394553 rs892541929	341	R>W		No	ClinGen gnomAD
CA395479313 rs1567243363	346	T>S		No	ClinGen Ensembl
rs1596606311 CA395479321	347	S>G		No	ClinGen Ensembl
COSM3937031 rs760747000 COSM3937029 CA7998034 COSM3937030	349	E>K	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA395479388 rs1257308058	350	S>I		No	ClinGen gnomAD
CA395479426 rs1423285576	352	H>P		No	ClinGen TOPMed
rs764083096 CA7998035	352	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1453862462 CA395479482	354	V>G		No	ClinGen gnomAD
rs754049338 CA7998036	354	V>L		No	ClinGen ExAC TOPMed gnomAD
rs1222639960 CA395479575	357	M>V		No	ClinGen gnomAD
CA280394632 rs1018529386	359	I>V		No	ClinGen TOPMed gnomAD
CA395479699 rs778654857	361	A>S		No	ClinGen ExAC TOPMed gnomAD
CA7998038 rs778654857	361	A>T		No	ClinGen ExAC TOPMed gnomAD
CA395479791 rs1354636051	364	Q>H		No	ClinGen gnomAD
CA7998039 rs145917075	364	Q>R		No	ClinGen ESP ExAC
rs1313504648 CA395479806	365	S>G		No	ClinGen gnomAD
CA280394650 rs372509673	365	S>R		No	ClinGen TOPMed
CA7998042 rs375972588	368	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1259110093 CA395480093	372	A>V		No	ClinGen gnomAD
rs1214795018 CA395480169	374	A>V		No	ClinGen TOPMed
TCGA novel	375	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769621464 CA7998046	377	N>D		No	ClinGen ExAC TOPMed gnomAD
rs760049440 CA7998049	378	E>K		No	ClinGen ExAC gnomAD
rs913318459 CA280394721	380	E>K		No	ClinGen TOPMed gnomAD
rs1252488322 CA395480492	385	E>K		No	ClinGen TOPMed
rs1204795871 CA395480509	386	E>K		No	ClinGen TOPMed
CA395480557 rs1240523500	388	E>K		No	ClinGen gnomAD
rs751116068 RCV001323067	388	E>missing		No	ClinVar dbSNP
rs1217237664 CA395480592	389	E>D		No	ClinGen TOPMed
rs772575258 CA7998061	389	E>K		No	ClinGen ExAC gnomAD
rs1419361953 CA395480607	390	E>V		No	ClinGen gnomAD
rs761114744 CA7998063	391	E>K		No	ClinGen ExAC gnomAD
rs1386636274 CA395480657	392	E>D		No	ClinGen TOPMed
CA395480649 rs1302665844	392	E>G		No	ClinGen TOPMed
rs753912286 CA7998065	393	G>V		No	ClinGen ExAC gnomAD
CA395480691 rs1432632673	395	E>K		No	ClinGen TOPMed gnomAD
rs1596606875 TCGA novel CA395480723	396	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
CA395480729 rs1462713646	397	R>G		No	ClinGen TOPMed
CA395480735 rs376173807	397	R>L		No	ClinGen ESP ExAC gnomAD
CA7998068 rs376173807	397	R>Q		No	ClinGen ESP ExAC gnomAD
rs1462713646 CA395480728	397	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs758131864 CA7998069	399	M>I		No	ClinGen ExAC TOPMed gnomAD
CA280394828 rs927256643	399	M>V		No	ClinGen TOPMed
CA395480791 rs1304933585	400	A>V		No	ClinGen gnomAD
rs35174880 CA7998070	401	M>V		No	ClinGen ExAC TOPMed gnomAD
CA280394852 rs377201939	402	M>L		No	ClinGen gnomAD
rs1303323663 CA395480829	402	M>R		No	ClinGen gnomAD
CA7998071 rs143466363	404	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1207720949 CA395480887	405	G>R		No	ClinGen gnomAD
rs1480735123 CA395480937	407	H>R		No	ClinGen gnomAD
CA395480951 rs1247745806	408	T>A		No	ClinGen gnomAD
rs1455217182 CA395480967	409	V>I		No	ClinGen gnomAD
rs1394416165 CA395480996	410	T>N		No	ClinGen gnomAD
CA395480989 rs1596607039	410	T>P		No	ClinGen Ensembl
rs1172229796 CA395481054	413	S>G		No	ClinGen gnomAD
TCGA novel	414	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998075 rs769569940	414	S>F		No	ClinGen ExAC gnomAD
CA7998076 rs777506344	415	I>V		No	ClinGen ExAC TOPMed gnomAD
CA395481143 rs1296704379	416	I>M		No	ClinGen gnomAD
rs78058418 CA280394912	416	I>T		No	ClinGen Ensembl
CA395481162 rs1596607097	417	H>P		No	ClinGen Ensembl
CA7998078 rs772522310	418	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs182132470 CA7998077	418	R>W	Variant assessed as Somatic; 7.945e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA395481191 rs1450138786	419	L>R		No	ClinGen gnomAD
rs775736451 CA7998079	420	P>L		No	ClinGen ExAC gnomAD
rs1321003401	421	G>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998101 rs769323834	423	D>G		No	ClinGen ExAC TOPMed gnomAD
CA395481421 rs769323834	423	D>V		No	ClinGen ExAC TOPMed gnomAD
CA395481544 rs1473954894	426	Y>C		No	ClinGen Ensembl
TCGA novel	427	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395481613 rs1596607760	428	D>A		No	ClinGen Ensembl
CA7998105 rs763141970	428	D>E		No	ClinGen ExAC gnomAD
CA395481642 rs1452310830	429	P>L		No	ClinGen gnomAD
rs1248475476 CA395481675	431	Q>E		No	ClinGen TOPMed
CA395481699 rs1315154656	432	P>A		No	ClinGen TOPMed gnomAD
rs1315154656 CA395481702	432	P>S		No	ClinGen TOPMed gnomAD
rs1414977223 CA395481732	433	E>D		No	ClinGen gnomAD
rs1356529488 CA395481724	433	E>G		No	ClinGen gnomAD
rs774195295 CA7998106	435	T>N		No	ClinGen ExAC TOPMed gnomAD
rs1224955381 CA395481797	438	P>R		No	ClinGen gnomAD
rs1386865466 CA395481799	439	L>I		No	ClinGen TOPMed
CA395481811 rs1418957987	440	Q>H		No	ClinGen TOPMed
CA7998110 rs371609102	441	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7998112 rs753436930	442	P>R		No	ClinGen ExAC gnomAD
CA395481828 rs1444677867	443	A>V		No	ClinGen TOPMed
rs756928555 CA7998113	444	A>S		No	ClinGen ExAC gnomAD
rs150531888 CA7998114	444	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1184947871 CA395481843	446	A>G		No	ClinGen TOPMed
CA395481848 rs1255686667	447	P>R		No	ClinGen gnomAD
rs1441119514 CA395481861	449	S>C		No	ClinGen TOPMed
CA280395304 rs138564043	450	T>A		No	ClinGen ESP gnomAD
CA7998117 rs781569715	450	T>N		No	ClinGen ExAC gnomAD
CA7998118 rs748606036	451	T>A		No	ClinGen ExAC gnomAD
rs748606036 CA7998119	451	T>P		No	ClinGen ExAC gnomAD
TCGA novel	453	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280395360 rs993846350	454	A>P		No	ClinGen Ensembl
CA7998121 rs535835029	454	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA7998122 rs771174306	455	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7998123 rs774381953	455	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1237813627 CA395481893	456	R>C		No	ClinGen gnomAD
CA7998125 rs771711319	456	R>H		No	ClinGen ExAC TOPMed gnomAD
CA395481900 rs1348255219	457	R>L		No	ClinGen gnomAD
rs1348255219 CA395481898	457	R>Q		No	ClinGen gnomAD
CA395481906 rs1209871229	458	A>V		No	ClinGen gnomAD
rs74981424 CA7998126	459	Y>S		No	ClinGen ExAC gnomAD
CA395481918 rs1439755593	460	C>S		No	ClinGen gnomAD
rs1025967617 CA280395416	461	R>C		No	ClinGen TOPMed gnomAD
CA7998127 rs146348272	461	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA280395442 rs900260278	462	N>S		No	ClinGen TOPMed
TCGA novel	463	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139763660 CA395481936	463	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998128 rs139763660	463	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA280395475 rs1008626163	465	H>P		No	ClinGen Ensembl
CA395481946 rs1396200475	465	H>Y		No	ClinGen gnomAD
rs1172133483 CA395481965	467	A>V		No	ClinGen TOPMed gnomAD
rs1411245776 CA395481979	470	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1329159589 CA395481981	470	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1443952323 CA395481995	472	A>V		No	ClinGen gnomAD
rs758092587 CA7998133	473	S>F		No	ClinGen ExAC gnomAD
CA7998150 rs761841772	476	S>R		No	ClinGen ExAC gnomAD
CA395484972 COSM969714 COSM969713 rs1278518808	477	R>H	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs974541828 CA280396962	484	Q>E		No	ClinGen Ensembl
CA7998151 rs764604543	484	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs762484136 CA7998153	486	S>A		No	ClinGen ExAC gnomAD
CA395485099 rs1460731028	486	S>Y		No	ClinGen TOPMed
rs1286967853 CA395485119	487	A>E		No	ClinGen gnomAD
CA395485142 rs1192915734	489	R>L		No	ClinGen TOPMed gnomAD
CA395485140 COSM233542 rs1192915734	489	R>Q	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs1189667865 CA395485206	494	G>D		No	ClinGen gnomAD
CA7998158 rs754246307	497	R>Q		No	ClinGen ExAC gnomAD
rs1460478609 CA395485244	497	R>W		No	ClinGen gnomAD
CA395485272 rs1401260670	499	R>Q		No	ClinGen gnomAD
rs778824846 CA7998160	500	R>Q		No	ClinGen ExAC gnomAD
CA395485288 rs1338177122	501	Q>K		No	ClinGen gnomAD
CA7998161 rs200883075	508	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7998163 rs772408260	512	R>L		No	ClinGen ExAC gnomAD
COSM1377295 COSM1377296 CA7998162 rs772408260	512	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA395485427 rs1246992068	512	R>W		No	ClinGen TOPMed
rs747237611 CA7998164	514	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1486860798 CA395485479	517	R>G		No	ClinGen gnomAD
CA7998165 rs768531269	517	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA395485481 COSM241844 rs1486860798	517	R>W	prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
CA7998167 rs748013785	522	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs772595318 CA7998169	523	R>Q		No	ClinGen ExAC gnomAD
CA7998168 rs769811063	523	R>W		No	ClinGen ExAC TOPMed gnomAD
rs142369950 CA7998171	526	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA280397195 rs376299348	526	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs773930903 CA7998172	528	L>F		No	ClinGen ExAC gnomAD
CA395485614 rs1313318145	529	E>*		No	ClinGen gnomAD
rs759204508 CA7998173	530	A>V		No	ClinGen ExAC gnomAD
rs991166338 CA280397211	531	Q>H		No	ClinGen TOPMed
CA395485642 rs1474933883	531	Q>R		No	ClinGen gnomAD
CA280397212 rs747450511	532	R>Q		No	ClinGen TOPMed gnomAD
rs373048486 CA7998175	532	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs757697666 CA7998176	533	A>G		No	ClinGen ExAC
CA395485698 rs1238878095	534	G>D		No	ClinGen gnomAD
rs1238878095 CA395485703	534	G>V		No	ClinGen gnomAD
CA7998177 rs765828326	535	F>L		No	ClinGen ExAC TOPMed gnomAD
rs750905955 CA7998178	536	G>A		No	ClinGen ExAC gnomAD
CA395485754 rs1235475784 COSM969720 COSM969719	537	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA395485777 rs1434403377	538	E>Q		No	ClinGen TOPMed
rs564533648 CA7998179	539	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA280397252 rs916776801	543	A>S		No	ClinGen gnomAD
CA395485916 rs916776801	543	A>T		No	ClinGen gnomAD
CA395485939 rs1198397765	543	A>V		No	ClinGen gnomAD
CA280397266 rs771339219	544	R>Q		No	ClinGen gnomAD
rs780311914 CA7998180	544	R>W		No	ClinGen ExAC TOPMed gnomAD
COSM1377297 CA7998182 rs755300621 COSM1377298	545	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs748043490 CA7998184	547	Q>H		No	ClinGen ExAC gnomAD
CA395486087 rs1239589256	548	A>V		No	ClinGen TOPMed
CA7998185 rs769608292	549	I>V		No	ClinGen ExAC TOPMed gnomAD
CA7998187 rs773147120	550	G>A		No	ClinGen ExAC gnomAD
rs773147120 CA7998186	550	G>V		No	ClinGen ExAC gnomAD
rs1397232670 CA395486206	552	K>E		No	ClinGen gnomAD
TCGA novel	552	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998189 rs773896207	554	A>T		No	ClinGen ExAC TOPMed gnomAD
CA7998190 rs759153586	555	R>P		No	ClinGen ExAC gnomAD
rs776843842 CA7998192	560	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1314042631 CA395486457	561	E>G		No	ClinGen TOPMed
CA395486447 rs1230526351	561	E>K		No	ClinGen gnomAD
CA395486475 rs1339726468	562	R>Q		No	ClinGen gnomAD
CA7998193 rs371473286	562	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA395486584 rs1235870063	565	Q>*		No	ClinGen gnomAD
rs750894918 CA395486646	567	H>N		No	ClinGen ExAC gnomAD
CA7998195 rs750894918	567	H>Y		No	ClinGen ExAC gnomAD
rs759005614 CA7998196	568	I>V		No	ClinGen ExAC gnomAD
TCGA novel	569	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751737195 CA7998198	573	K>Q		No	ClinGen ExAC gnomAD
CA7998199 rs755236889	574	K>E		No	ClinGen ExAC gnomAD
rs1311721853 CA395486873	574	K>N		No	ClinGen TOPMed
CA280397409 rs1049338916	576	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1465339344 CA395486956	578	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395486979 rs1396815414	580	L>V		No	ClinGen gnomAD
CA7998203 rs777448049	582	A>V		No	ClinGen ExAC gnomAD
CA280397451 rs886400996	585	R>W		No	ClinGen TOPMed
TCGA novel	586	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998204 rs373817628	588	K>R		No	ClinGen ESP ExAC gnomAD
rs770907647 CA7998205	590	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770907647 CA395487171	590	R>L		No	ClinGen ExAC TOPMed gnomAD
rs778384842 CA7998206	593	Q>R		No	ClinGen ExAC gnomAD
CA395487265 rs1567246698	595	K>R		No	ClinGen Ensembl
rs779463362 CA7998226	598	L>F		No	ClinGen ExAC gnomAD
CA395487371 rs1567246884	598	L>H		No	ClinGen Ensembl
rs1214657654 CA395487378	599	Q>*		No	ClinGen gnomAD
rs1259853271 CA395487383	599	Q>R		No	ClinGen gnomAD
rs1475694204 CA395487435	603	S>R		No	ClinGen TOPMed gnomAD
CA7998228 rs768242398	605	P>R		No	ClinGen ExAC gnomAD
CA395487499 rs773698336	607	R>L		No	ClinGen ExAC TOPMed gnomAD
rs773698336 CA7998229	607	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1421345639 CA395487495	607	R>W		No	ClinGen gnomAD
CA395487542 rs1418267815	610	A>G		No	ClinGen gnomAD
CA7998232 rs774939081	611	E>D		No	ClinGen ExAC gnomAD
CA280397632 rs958428636	611	E>K		No	ClinGen Ensembl
CA395487563 rs1596612634	612	W>G		No	ClinGen Ensembl
CA7998233 rs759980483	612	W>S		No	ClinGen ExAC gnomAD
CA395487591 rs767589606	615	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7998235 rs752773455	615	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7998234 rs767589606	615	R>W		No	ClinGen ExAC TOPMed gnomAD
rs764370184 CA7998237	620	L>F		No	ClinGen ExAC gnomAD
CA395487675 rs1567247125	621	Q>*		No	ClinGen Ensembl
CA395487708 rs1486107610	623	C>F		No	ClinGen gnomAD
rs756991109 CA7998239	623	C>R		No	ClinGen ExAC TOPMed gnomAD
rs61737877 CA7998240	625	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7998242 rs758308556	626	E>G		No	ClinGen ExAC gnomAD
rs866396115 CA280397693	628	E>G		No	ClinGen Ensembl
rs1175895944 CA395487768	629	A>T		No	ClinGen gnomAD
CA7998244 rs746558110	629	A>V		No	ClinGen ExAC gnomAD
rs141485756 CA7998246	631	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1335235322 CA395487810	632	L>P		No	ClinGen TOPMed
CA7998249 rs774884028	633	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs771370720 CA7998248	633	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	634	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1444531731 CA395487826	634	R>Q		No	ClinGen gnomAD
rs746350821 CA7998250	634	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1345489471 CA395487849	636	R>C		No	ClinGen gnomAD
CA7998251 rs772517477	636	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7998252 rs775639559	637	Q>E		No	ClinGen ExAC gnomAD
rs760608251 CA7998253	637	Q>H		No	ClinGen ExAC gnomAD
CA7998254 rs764175840	638	Y>C		No	ClinGen ExAC gnomAD
rs1382401335 CA395487934	642	Q>H		No	ClinGen TOPMed
CA7998255 rs776787473	644	R>C		No	ClinGen ExAC gnomAD
CA395487950 rs776787473	644	R>G		No	ClinGen ExAC gnomAD
rs762055796 CA7998256	644	R>H		No	ClinGen ExAC TOPMed gnomAD
rs996193871 CA280397776	645	Q>H		No	ClinGen gnomAD
CA280397770 rs901881004	645	Q>P		No	ClinGen Ensembl
rs750234872 CA7998258	647	K>E		No	ClinGen ExAC gnomAD
rs758342146 CA7998259	648	R>C		No	ClinGen ExAC TOPMed gnomAD
rs758342146 CA395488004	648	R>G		No	ClinGen ExAC TOPMed gnomAD
rs892936316 CA395488005	648	R>H		No	ClinGen Ensembl
CA280397792 rs892936316	648	R>L		No	ClinGen Ensembl
CA395488038 rs1596613064	650	M>I		No	ClinGen Ensembl
rs551868876 CA280397811	654	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7998263 rs780869753	654	R>Q		No	ClinGen ExAC gnomAD
rs551868876 CA7998261	654	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7998264 rs747760164	656	S>I		No	ClinGen ExAC
rs1327843933 CA395488174	658	D>E		No	ClinGen gnomAD
rs144910819 CA7998265	658	D>N		No	ClinGen ESP ExAC gnomAD
rs779412253 CA7998266	659	Q>E		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	660	D>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998267 rs746288522	660	D>V		No	ClinGen ExAC gnomAD
rs1020575217 CA395488254	663	R>G		No	ClinGen TOPMed
rs772493861 CA7998268	663	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA280397842 rs1020575217	663	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs777255470 CA280397846	664	E>Q		No	ClinGen TOPMed
rs748293084 CA7998291	665	D>N		No	ClinGen ExAC gnomAD
CA395488534 rs773248587 CA7998293	667	N>K		No	ClinGen ExAC gnomAD
rs763256431 CA7998294	669	K>Q		No	ClinGen ExAC
rs1216473159 CA395488670	675	L>F		No	ClinGen TOPMed
CA395488688 rs1258578574	678	A>T		No	ClinGen gnomAD
CA395488695 rs1334866099	679	L>V		No	ClinGen gnomAD
rs759519804 CA7998297	682	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7998296 COSM1267397 rs774239550 COSM1267396	682	R>W	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA280398362 rs543666690	684	H>D		No	ClinGen 1000Genomes
rs201394687 CA7998299	685	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201560518 CA280398370	685	E>G		No	ClinGen gnomAD
CA395488762 rs1396457128	685	E>K		No	ClinGen TOPMed
CA7998300 rs372787552 COSM1267393 COSM1267394	687	T>M	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA7998303 rs756975773	688	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753394748 CA7998302	688	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA395488827 rs1455337379	690	L>V		No	ClinGen TOPMed
CA395488833 rs1253214945	691	E>K		No	ClinGen TOPMed
rs755472068 CA7998306	693	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7998305 rs780259481	693	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA395488882 rs1468316022	694	Q>R		No	ClinGen TOPMed
rs541201834 CA7998308	698	V>L		No	ClinGen 1000Genomes ExAC gnomAD
rs541201834 CA7998309	698	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1394353002 CA395488956	699	Q>H		No	ClinGen gnomAD
rs777936445 CA7998310	700	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs777936445 CA395488962	700	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7998311 rs749437354	700	R>H		No	ClinGen ExAC gnomAD
CA7998313 rs773999686	701	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1256207952 CA395488996	703	A>T		No	ClinGen gnomAD
CA7998316 rs55893926	703	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1198195420 CA395489064	705	L>P		No	ClinGen gnomAD
rs1458122828 CA395489085	706	T>I		No	ClinGen gnomAD
CA7998317 rs760728409	706	T>P		No	ClinGen ExAC gnomAD
CA395489103 rs1236066028	707	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs559551824 CA7998319	707	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	709	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395489275 rs1173949164	711	Q>H		No	ClinGen gnomAD
rs1406395729 CA395489290	712	T>M		No	ClinGen gnomAD
CA280398465 rs1042209489	715	G>V		No	ClinGen Ensembl
rs767889343 CA7998324	721	N>S		No	ClinGen ExAC gnomAD
TCGA novel	722	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998325 rs753160957	723	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA280398500 rs756682464	724	R>C		No	ClinGen ExAC TOPMed gnomAD
rs867355297 CA280398505	724	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs867355297 CA395489606	724	R>L		No	ClinGen TOPMed gnomAD
rs756682464 CA7998326	724	R>S		No	ClinGen ExAC TOPMed gnomAD
rs143012134 CA7998328	726	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs143012134 CA7998327	726	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998329 rs757412915	727	E>A		No	ClinGen ExAC gnomAD
CA395489703 rs1256067563	727	E>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs779224250 CA280398523	729	R>W		No	ClinGen ExAC gnomAD
CA7998331 rs746118559	733	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775467090 CA7998333	734	A>S		No	ClinGen ExAC TOPMed gnomAD
rs746899846 CA7998334	735	Q>E		No	ClinGen ExAC
CA395489985 rs1596614914	736	V>G		No	ClinGen Ensembl
CA280398537 rs796285883	736	V>I		No	ClinGen gnomAD
CA395490017 rs1352088641	737	R>H		No	ClinGen TOPMed gnomAD
CA7998336 rs776001863	742	S>N		No	ClinGen ExAC TOPMed gnomAD
CA395490265 rs1596614971	745	V>G		No	ClinGen Ensembl
rs563881487 CA7998338	746	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs377399375 CA7998339	746	R>H		No	ClinGen ESP ExAC
rs978611776 CA280398549	747	A>V		No	ClinGen TOPMed gnomAD
rs762623585 CA7998340	750	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs767834118 CA7998342	750	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1245457402 CA395490403	751	P>S		No	ClinGen TOPMed gnomAD
rs753107537 CA7998343	752	P>L		No	ClinGen ExAC TOPMed
CA395490435 rs753107537	752	P>R		No	ClinGen ExAC TOPMed
CA7998346 rs754317954	753	G>D		No	ClinGen ExAC gnomAD
CA395490467 rs754317954	753	G>V		No	ClinGen ExAC gnomAD
rs141593689 CA7998347	754	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA395490491 rs1488108144	755	P>A		No	ClinGen gnomAD
CA7998348 rs779167423	755	P>L		No	ClinGen ExAC gnomAD
CA7998350 rs758744945	758	I>V		No	ClinGen ExAC TOPMed
rs1299265690 CA395490628	761	A>S		No	ClinGen TOPMed gnomAD
CA7998352 rs746888550	761	A>V		No	ClinGen ExAC gnomAD
rs1177683377 CA395490652	763	G>S		No	ClinGen TOPMed gnomAD
CA7998353 rs768342491	764	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7998355 rs748058489	765	P>L		No	ClinGen ExAC gnomAD
rs767332536 CA280398640	766	N>S		No	ClinGen Ensembl
rs1180573760 CA395490710	766	N>Y		No	ClinGen TOPMed
CA395490732 rs1319923797	767	T>A		No	ClinGen gnomAD
rs772748056 CA7998357	767	T>I		No	ClinGen ExAC gnomAD
rs992122323 CA280398647	768	G>D		No	ClinGen TOPMed
CA7998360 rs199554981	769	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7998359 rs199554981	769	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761030327 CA395490836	775	P>A		No	ClinGen ExAC gnomAD
rs761030327 CA7998361	775	P>S		No	ClinGen ExAC gnomAD
CA7998362 rs371212254	776	C>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA395490846 rs1181418672	776	C>W		No	ClinGen gnomAD
rs754333462 CA7998363	777	S>L		No	ClinGen ExAC gnomAD
CA280398704 rs61737884	778	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7998365 rs547599281	778	P>L		No	ClinGen 1000Genomes ExAC
RCV000957402 CA7998364 rs61737884	778	P>S		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA395490884 rs1380101195	780	Q>R		No	ClinGen gnomAD
rs750589804 CA7998366	782	A>P		No	ClinGen ExAC gnomAD
rs758689808 CA7998367	783	V>I		No	ClinGen ExAC gnomAD
rs780356988 CA7998368	784	L>V		No	ClinGen ExAC gnomAD
rs751742851 CA395490989	787	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1235011512 CA395491007	788	M>I		No	ClinGen TOPMed
rs780878586 CA7998371	788	M>T		No	ClinGen ExAC gnomAD
CA7998370 rs754752396	788	M>V		No	ClinGen ExAC gnomAD
CA7998372 rs748086166	789	L>F		No	ClinGen ExAC gnomAD
rs965191672 CA280398729	789	L>H		No	ClinGen gnomAD
CA7998374 rs777249780	790	G>D		No	ClinGen ExAC gnomAD
rs748859380 CA7998377	791	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1209469922 CA395491057	792	E>K		No	ClinGen gnomAD
CA280398758 rs369242417	794	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs770429011 CA7998378	794	E>K		No	ClinGen ExAC gnomAD
TCGA novel	800	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280398783 rs192505565	802	L>Q		No	ClinGen 1000Genomes TOPMed
CA7998382 rs769037390	803	G>V		No	ClinGen ExAC gnomAD
CA395491287 rs1426792374	805	E>V		No	ClinGen TOPMed gnomAD
rs1299220336 CA395491299	806	G>R		No	ClinGen gnomAD
CA7998384 rs762396870	807	A>T		No	ClinGen ExAC gnomAD
CA395491346 rs765912677	808	T>A		No	ClinGen ExAC TOPMed
CA7998385 rs765912677 RCV001352268	808	T>P		No	ClinGen ClinVar ExAC TOPMed dbSNP
CA7998386 rs750971493	809	L>S		No	ClinGen ExAC gnomAD
rs750971493 CA7998387	809	L>W		No	ClinGen ExAC gnomAD
TCGA novel	810	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998388 rs766586652	810	E>V		No	ClinGen ExAC TOPMed gnomAD
CA280398813 rs142024220	811	P>A		No	ClinGen ESP
CA7998390 rs755195552	812	K>R		No	ClinGen ExAC TOPMed gnomAD
rs150689389 CA7998391 RCV000899159	813	Q>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7998393 rs558241184 RCV000943535	821	S>L		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs202135474 CA280398848	822	G>R		No	ClinGen Ensembl
rs777617556 CA7998394	824	P>L		No	ClinGen ExAC gnomAD
CA7998395 rs749234269	826	P>S		No	ClinGen ExAC TOPMed gnomAD
rs74854860 CA280398870	831	H>R		No	ClinGen ESP TOPMed gnomAD
rs924684117 CA280398872	833	S>I		No	ClinGen Ensembl
TCGA novel	833	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770390468 CA7998396	834	L>M		No	ClinGen ExAC TOPMed gnomAD
CA7998398 rs745515041	836	D>N		No	ClinGen ExAC TOPMed gnomAD
CA395492201 rs1247676673	837	E>Q		No	ClinGen TOPMed gnomAD
rs771680677 CA7998399	838	E>D		No	ClinGen ExAC gnomAD
rs117592185 CA7998400	840	W>G		No	ClinGen 1000Genomes ExAC gnomAD
rs1426513389 CA395492315	841	G>V		No	ClinGen TOPMed gnomAD
rs748459591 CA7998401	842	L>V		No	ClinGen ExAC gnomAD
rs370350268 CA7998402	843	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	843	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395492457 rs375935255	845	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs766451008 CA7998406	846	I>M		No	ClinGen ExAC TOPMed gnomAD
CA7998405 rs763583385	846	I>T		No	ClinGen ExAC gnomAD
CA395492507 rs1435945558	847	E>K		No	ClinGen gnomAD
CA395492541 rs1301507535	848	E>K		No	ClinGen gnomAD
rs759787568 CA7998408	849	L>P		No	ClinGen ExAC gnomAD
rs774342911 CA7998407	849	L>V		No	ClinGen ExAC gnomAD
CA395492632 rs1163117187	850	R>K		No	ClinGen TOPMed
rs139952928 CA395492640	850	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs755844002 CA7998411	851	V>G		No	ClinGen ExAC gnomAD
rs752917907 CA395492656	851	V>L		No	ClinGen ExAC TOPMed gnomAD
CA7998410 rs752917907	851	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7998412 rs763911645	852	P>H		No	ClinGen ExAC TOPMed gnomAD
rs763911645 CA280398930	852	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA395492695 rs1290949015	852	P>S		No	ClinGen gnomAD
CA7998413 rs149357185	854	L>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA395492737 rs1567249451	854	L>V		No	ClinGen Ensembl
rs1215399730 CA395492780	856	P>L		No	ClinGen TOPMed
rs757238729 CA395492862	859	R>G		No	ClinGen ExAC TOPMed gnomAD
CA7998414 rs757238729	859	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7998416 rs745437107	860	S>R		No	ClinGen ExAC gnomAD
CA395492917 rs1422321038	861	I>T		No	ClinGen gnomAD
rs1207933586 CA395493110	869	T>A		No	ClinGen TOPMed
CA7998418 rs537042619	869	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770242526 CA7998421	873	W>L		No	ClinGen ExAC TOPMed gnomAD
CA7998420 rs770242526	873	W>S		No	ClinGen ExAC TOPMed gnomAD
CA395493341 rs1443570802	875	K>R		No	ClinGen TOPMed
TCGA novel	876	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763865713 CA280399036	877	D>H		No	ClinGen Ensembl
TCGA novel	878	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA7998422 rs749790271	881	L>V		No	ClinGen ExAC gnomAD
TCGA novel	882	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1297610371 CA395493540	882	D>V		No	ClinGen gnomAD
CA280399045 rs997918254	883	E>D		No	ClinGen Ensembl
CA395493593 rs1324764918	884	E>G		No	ClinGen gnomAD
TCGA novel	884	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771398541 CA7998423	887	L>P		No	ClinGen ExAC gnomAD
rs1430613115 CA395493773	889	W>C		No	ClinGen gnomAD
CA7998425 rs759463491	889	W>S		No	ClinGen ExAC TOPMed gnomAD
rs767646576 CA7998426	891	Q>R		No	ClinGen ExAC gnomAD
rs1355347469 CA395493855	894	A>S		No	ClinGen gnomAD
CA395493858 rs1216926728	894	A>V		No	ClinGen gnomAD
CA280399102 rs574261683	896	T>I		No	ClinGen Ensembl
CA7998431 rs145442196	898	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998432 rs573977459	899	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs750389837 CA7998433	900	E>A		No	ClinGen ExAC gnomAD
rs377728634 CA7998435	905	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998436 rs779645307	905	E>V		No	ClinGen ExAC gnomAD
TCGA novel	907	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754726955 CA7998438	909	A>S		No	ClinGen ExAC TOPMed gnomAD
rs754726955 CA280399131	909	A>T		No	ClinGen ExAC TOPMed gnomAD
rs778268053 COSM3690912 COSM3690911 CA7998439	910	P>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs909457929 RCV001326753 CA280399143	911	I>T		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA395494313 rs1378116017	913	T>N		No	ClinGen gnomAD
rs1194799603 CA395494333	914	P>S		No	ClinGen TOPMed
rs1339361800 CA395494388	916	D>E		No	ClinGen TOPMed
rs1460907216 CA395494399	917	P>A		No	ClinGen gnomAD
rs1240351892 CA395494447	919	D>Y		No	ClinGen gnomAD
rs749733211 CA7998440	922	P>L		No	ClinGen ExAC TOPMed gnomAD
rs749733211 CA280399167	922	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1348147264 CA395494539	923	S>P		No	ClinGen gnomAD
CA280399187 rs867958493	925	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA395494607 rs1460785183	926	I>V		No	ClinGen gnomAD
CA395494682 rs1596616483	929	E>D		No	ClinGen Ensembl
CA280399189 rs969034315	930	P>S		No	ClinGen TOPMed
CA7998442 rs779227926	934	H>L		No	ClinGen ExAC gnomAD
CA395496529 rs779227926	934	H>P		No	ClinGen ExAC gnomAD
CA395496548 rs1440058731	934	H>Q		No	ClinGen TOPMed gnomAD
CA395496525 rs1596616517	934	H>Y		No	ClinGen Ensembl
rs772017668 CA7998445	937	P>L		No	ClinGen ExAC TOPMed gnomAD
CA395496598 rs1362248747	937	P>S		No	ClinGen gnomAD
rs200702514 CA7998446	938	C>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA395496641 rs1468639624	939	P>L		No	ClinGen gnomAD
CA395496634 rs1401625251	939	P>S		No	ClinGen gnomAD
rs370623476 CA7998447	940	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA395496670 rs1401737575	941	S>R		No	ClinGen gnomAD
CA7998448 rs768936564	942	Q>H		No	ClinGen ExAC gnomAD
CA395496673 rs1446464907	942	Q>K		No	ClinGen gnomAD
rs1435608823 CA395496706	944	P>T		No	ClinGen TOPMed
CA395496725 rs1234999758	945	G>R		No	ClinGen gnomAD
rs750289878 CA7998455	951	L>F		No	ClinGen ExAC gnomAD
rs750289878 CA7998454	951	L>I		No	ClinGen ExAC gnomAD
rs1248182340 CA395496841	951	L>P		No	ClinGen gnomAD
rs1428613332 CA395496863	953	A>T		No	ClinGen gnomAD
CA395496881 rs1479491292	953	A>V		No	ClinGen gnomAD
rs752404075 CA7998461	954	G>A		No	ClinGen ExAC gnomAD
CA7998459 rs374422460	954	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998460 rs752404075	954	G>V		No	ClinGen ExAC gnomAD
CA395496893 rs1181348040	955	L>F		No	ClinGen TOPMed
CA7998462 rs779363895	958	A>V		No	ClinGen ExAC gnomAD
CA395497032 rs1596616850	961	S>T		No	ClinGen Ensembl
rs368349313 CA280400390	962	S>F		No	ClinGen ESP TOPMed gnomAD
CA395497114 rs1474280101	963	S>Y		No	ClinGen Ensembl
CA395497133 rs1279600569	965	L>I		No	ClinGen gnomAD
CA395497172 rs1184778082	967	P>L		No	ClinGen Ensembl
rs1226649608 CA395497158	967	P>T		No	ClinGen gnomAD
rs1358807686 CA395497273	972	L>P		No	ClinGen TOPMed
CA395497296 rs1264035631	974	L>F		No	ClinGen gnomAD
rs1596617041 CA395497391	978	A>E		No	ClinGen Ensembl
rs1408415439 CA395497460	981	G>D		No	ClinGen TOPMed
CA395497471 rs1458728329	982	G>R		No	ClinGen gnomAD
rs1370755774	983	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA395497540 rs1402743256	986	Q>*		No	ClinGen gnomAD
CA280400416 rs368557354	987	A>S		No	ClinGen ESP TOPMed gnomAD
rs371334367 CA280400419	987	A>V		No	ClinGen ESP TOPMed gnomAD
rs201030524 CA7998476	988	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1357498708 CA395497623	991	A>G		No	ClinGen gnomAD
rs1357498708 CA395497625	991	A>V		No	ClinGen gnomAD
CA395497631 rs1219079424	992	L>F		No	ClinGen gnomAD
CA395497660 rs1490036487	993	E>D		No	ClinGen gnomAD
rs759054733 CA7998479	995	G>V		No	ClinGen ExAC gnomAD
CA7998480 rs767155571	996	L>P		No	ClinGen ExAC TOPMed gnomAD
rs752250092 CA7998481	997	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1183321738 CA395497722	998	G>C		No	ClinGen gnomAD
CA7998483 rs779135850	1000	G>V		No	ClinGen ExAC gnomAD
rs778607509 CA280400459	1003	Y>C		No	ClinGen TOPMed gnomAD
rs778607509 CA395497792	1003	Y>S		No	ClinGen TOPMed gnomAD
rs1234051453 CA395497809	1004	L>Q		No	ClinGen TOPMed
rs758771154 CA7998485	1005	L>F		No	ClinGen ExAC gnomAD
CA7998487 rs368171889	1006	L>F		No	ClinGen ESP ExAC gnomAD
CA7998486 rs368171889	1006	L>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	1007	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395497881 rs1396567805	1008	T>I		No	ClinGen gnomAD
CA395497884 rs1314022526	1009	A>T		No	ClinGen TOPMed gnomAD
rs948537507 CA280400499	1009	A>V		No	ClinGen Ensembl
rs1596617387 CA395497931	1011	H>Q		No	ClinGen Ensembl
CA7998491 rs770111165	1013	P>L		No	ClinGen ExAC gnomAD
CA395497943 rs1287001693	1013	P>S		No	ClinGen gnomAD
rs1483843891 CA395497998	1018	L>V		No	ClinGen gnomAD
rs1241626262 CA395498013	1019	L>F		No	ClinGen TOPMed gnomAD
rs1241626262 CA395498009	1019	L>I		No	ClinGen TOPMed gnomAD
CA395498036 rs1179728929	1021	A>T		No	ClinGen gnomAD
rs1408226261 CA395498045	1022	Q>K		No	ClinGen gnomAD
rs1418199770 CA395498054	1022	Q>R		No	ClinGen gnomAD
rs1048258295 CA280400516	1023	G>S		No	ClinGen Ensembl
CA395498080 rs1156261345	1024	T>A		No	ClinGen TOPMed gnomAD
CA280400518 rs909787343	1024	T>I		No	ClinGen Ensembl
rs1261463041 CA395498100	1025	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs774378915 CA7998495	1026	L>V		No	ClinGen ExAC TOPMed gnomAD
CA7998496 rs200094589	1027	G>R		No	ClinGen 1000Genomes ExAC gnomAD
CA7998498 rs140857929	1029	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA395498247 rs1222316235	1032	L>P		No	ClinGen gnomAD
CA7998500 rs763739523	1033	S>G		No	ClinGen ExAC gnomAD
rs1312865991 CA395498288	1034	W>*		No	ClinGen gnomAD
CA395498296 rs1223048815	1035	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA7998501 rs144609126	1035	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA395498305 rs1459511676	1036	R>*		No	ClinGen gnomAD
CA7998502 rs146662869	1036	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1596617740 CA395498324	1037	G>A		No	ClinGen Ensembl
rs1480068036 CA395498349	1039	M>V		No	ClinGen gnomAD
rs1426902378 CA395498397	1041	V>I		No	ClinGen gnomAD
rs1016930399 CA280400639	1042	P>L		No	ClinGen TOPMed gnomAD
CA395498430 rs1016930399	1042	P>R		No	ClinGen TOPMed gnomAD
rs1467139496 CA395498491	1045	L>V		No	ClinGen gnomAD
rs1329255988 CA395498513	1046	G>R		No	ClinGen gnomAD
CA395498549 rs1353715685	1047	A>T		No	ClinGen gnomAD
rs1440224288 CA395498576	1047	A>V		No	ClinGen gnomAD
rs565696351 CA7998505	1048	A>P		No	ClinGen 1000Genomes ExAC gnomAD
rs565696351 CA395498581	1048	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs748325493 CA7998507	1049	W>*		No	ClinGen ExAC gnomAD
rs781117726 CA7998506	1049	W>L		No	ClinGen ExAC gnomAD
rs1281510718 CA395498642	1050	L>F		No	ClinGen gnomAD
rs1219787134 CA395498704	1052	A>S		No	ClinGen gnomAD
rs1297054153 CA395498771	1053	W>C		No	ClinGen TOPMed
CA395498852 rs1432713751	1057	A>V		No	ClinGen TOPMed
rs1306112043 CA395498912	1059	P>L		No	ClinGen gnomAD
rs777989484 CA7998509	1061	V>M		No	ClinGen ExAC gnomAD
rs369823069 CA7998511	1063	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs774325942 CA7998513 COSM1377300	1065	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed
COSM1301847 CA280400712 rs972217949	1067	G>D	Variant assessed as Somatic; impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA395499179 rs972217949	1067	G>V		No	ClinGen TOPMed gnomAD
rs752509959	1068	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA7998515 rs772206724	1069	W>R		No	ClinGen ExAC gnomAD
rs775298762 CA7998516	1070	V>L		No	ClinGen ExAC gnomAD
CA7998519 rs776308173	1071	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs763535632 CA7998518	1071	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA395499274 rs533140450	1072	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7998520 rs533140450	1072	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1342464401 CA395499331	1073	Q>*		No	ClinGen gnomAD
rs1270124447 CA395499360	1074	G>D		No	ClinGen gnomAD
rs373055729 CA7998522	1074	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs755470822 CA7998523	1075	P>L		No	ClinGen ExAC gnomAD
rs753157774 CA395499407	1076	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7998525 rs753157774	1076	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7998524 rs768000716	1076	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7998526 rs756165206	1077	V>L		No	ClinGen ExAC TOPMed gnomAD
rs777742559 CA7998527	1078	R>C		No	ClinGen ExAC gnomAD
rs754079189 CA7998528	1078	R>H		No	ClinGen ExAC TOPMed gnomAD
rs757599173 CA7998529	1079	R>Q		No	ClinGen ExAC gnomAD
CA395499467 rs1474414444	1079	R>W		No	ClinGen gnomAD
CA395499492 rs1424189692	1080	G>D		No	ClinGen gnomAD
CA7998530 rs778850239	1080	G>R		No	ClinGen ExAC TOPMed gnomAD
CA280400798 rs942365388	1081	I>M		No	ClinGen TOPMed
rs1567250822 CA395499509	1081	I>V		No	ClinGen Ensembl
rs771780720 CA7998532	1083	R>Q		No	ClinGen ExAC gnomAD
CA395499581 rs1243048569	1084	L>F		No	ClinGen TOPMed gnomAD
rs1401327054 CA395499617	1085	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA280400800 rs1031649698	1087	R>G		No	ClinGen TOPMed gnomAD
CA280400823 rs925207056	1087	R>Q		No	ClinGen TOPMed gnomAD
CA280400820 rs1031649698	1087	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA395499732 rs1382519704	1091	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7998533 rs779997095	1091	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1432898900 CA395499863	1095	M>I		No	ClinGen TOPMed
CA7998536 rs776168886	1095	M>T		No	ClinGen ExAC gnomAD
rs570111696 CA7998535	1095	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1423760081 CA395499916	1097	F>L		No	ClinGen TOPMed
CA280400868 COSM1470849 rs970207198	1098	R>Q	prostate Variant assessed as Somatic; 0.0001391 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs761440065 CA7998537	1098	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1203054773 CA395499943	1099	A>S		No	ClinGen TOPMed
CA7998540 rs200281592	1101	Q>R		No	ClinGen TOPMed
rs767790551 CA7998545	1109	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs759836142 CA7998544	1109	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1013415121 CA280400928	1110	G>S		No	ClinGen TOPMed
CA395500290 rs1337949451	1112	F>L		No	ClinGen gnomAD
TCGA novel	1113	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs764209611 CA7998548	1114	L>V		No	ClinGen ExAC gnomAD
rs750700093 CA7998552	1119	N>K		No	ClinGen ExAC gnomAD
rs779222499 CA7998551	1119	N>S		No	ClinGen ExAC gnomAD
CA395500423 rs1278377206	1121	D>H		No	ClinGen gnomAD
CA280400972 rs113853312	1122	G>D		No	ClinGen Ensembl
rs1347901538 CA395500442	1122	G>S		No	ClinGen gnomAD
COSM1228489 CA280400977 rs905235426	1124	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs750925824 CA280401008	1126	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs189332502 CA7998554	1126	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs78092725 CA7998557	1129	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7998559 rs769306491	1131	G>A		No	ClinGen ExAC gnomAD
CA7998561 rs762541075	1132	P>L		No	ClinGen ExAC gnomAD
rs147468853 CA7998563	1133	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs772447624 CA7998562	1133	R>W		No	ClinGen ExAC TOPMed gnomAD
CA7998565 rs545581481	1134	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761228642 CA7998564	1134	R>W		No	ClinGen ExAC gnomAD
CA280401034 rs954914582	1135	R>C		No	ClinGen TOPMed
CA7998568 rs374855838	1135	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1406219826 CA395500612	1136	N>D		No	ClinGen gnomAD
rs1209067791 CA395500638	1137	P>L		No	ClinGen TOPMed
CA7998570 rs557300662	1138	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395500654 rs1221615653	1138	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1340533086 CA395500659	1139	T>A		No	ClinGen TOPMed
CA7998571 rs766185229	1139	T>I		No	ClinGen ExAC TOPMed gnomAD
rs1567251310 CA395500710	1142	H>Y		No	ClinGen Ensembl
CA7998572 rs751374679	1143	P>L		No	ClinGen ExAC gnomAD
rs1248650704 CA395500745	1144	L>S		No	ClinGen gnomAD
rs781049167 CA7998574	1148	A>T		No	ClinGen ExAC TOPMed gnomAD
CA280401099 rs1031930816	1149	R>S		No	ClinGen TOPMed gnomAD
rs1322987636 CA395500838	1150	V>F		No	ClinGen TOPMed
CA395500866 rs1173182915	1151	W>*		No	ClinGen gnomAD
rs1388636808 CA395500876	1152	V>F		No	ClinGen TOPMed
rs200334119 CA7998578	1160	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA395501036 rs1567251403	1162	A>V		No	ClinGen Ensembl
CA7998580 rs143930866	1163	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395501068 rs1402619693	1165	S>G		No	ClinGen gnomAD
TCGA novel	1165	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1297635790 CA395501075	1165	S>T		No	ClinGen gnomAD
CA7998582 rs769166765	1166	Q>R		No	ClinGen ExAC gnomAD
CA280401171 rs970533552	1167	G>D		No	ClinGen TOPMed gnomAD
CA395501110 rs970533552	1167	G>V		No	ClinGen TOPMed gnomAD
CA7998583 rs777238588	1169	A>T		No	ClinGen ExAC gnomAD
CA395501161 rs1223511523	1170	S>P		No	ClinGen TOPMed gnomAD
rs371354252 CA7998584	1173	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA395501255 rs371354252	1173	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA7998587 rs375289466	1174	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA395501284 rs375289466	1174	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs878872050 CA280401191	1175	W>G		No	ClinGen Ensembl
CA395501413 rs1215457514	1178	H>R		No	ClinGen TOPMed
rs1356484232 CA395501439	1179	T>I		No	ClinGen TOPMed
rs767326939 CA7998591	1181	A>T		No	ClinGen ExAC gnomAD
rs1264378100 CA395501484	1181	A>V		No	ClinGen TOPMed
rs1327839352 CA395501622	1186	L>F		No	ClinGen TOPMed
rs1364648297 CA395501645	1187	R>L		No	ClinGen TOPMed gnomAD
CA395501653 rs1364648297	1187	R>Q		No	ClinGen TOPMed gnomAD
rs1163810684 CA395501640	1187	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA7998594 rs777250056	1188	G>S		No	ClinGen ExAC gnomAD
rs1364899186 CA395501679	1188	G>V		No	ClinGen TOPMed
CA395501694 rs1319182013	1189	E>K		No	ClinGen TOPMed
CA395501746 rs778381460	1190	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7998597 rs778381460	1190	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7998596 rs756806042	1190	R>W		No	ClinGen ExAC TOPMed gnomAD
CA395501761 rs1246519045	1191	P>S		No	ClinGen gnomAD
CA395501807 rs1264132970	1193	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395501812 rs1357616561	1193	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395501826 rs1217977686	1194	I>V		No	ClinGen gnomAD
CA395501860 rs1261415972	1195	P>L		No	ClinGen gnomAD
rs540709989 CA7998602 COSM417054	1196	R>Q	urinary_tract [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA7998600 rs777189424	1196	R>W		No	ClinGen ExAC TOPMed gnomAD
rs762880651 CA7998604	1197	L>V		No	ClinGen ExAC gnomAD
CA395501934 rs1596619394	1198	L>P		No	ClinGen Ensembl
CA280401273 rs984235071	1198	L>V		No	ClinGen TOPMed
CA7998607 rs371014944	1200	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7998606 rs371014944	1200	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs767277640 CA7998608	1200	R>H		No	ClinGen ExAC gnomAD
rs905288414 CA280401302	1202	Q>P		No	ClinGen TOPMed
CA395502055 rs1318448458	1203	R>C		No	ClinGen TOPMed gnomAD
rs752545505 CA7998610	1203	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7998611 rs760600341	1204	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA395502090 rs1453067603	1204	Q>P		No	ClinGen gnomAD
rs961237314 CA280401322	1206	G>E		No	ClinGen Ensembl
rs2069863285 RCV001310055	1206	G>R		No	ClinVar dbSNP
rs373807941 CA7998613	1207	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA280401333 rs993457550	1208	P>S		No	ClinGen TOPMed
CA280401340 rs922513697	1209	A>G		No	ClinGen Ensembl
rs267604505 CA280401342	1210	S>F		No	ClinGen Ensembl
rs562874743 CA7998615	1211	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs11864149 CA7998616	1211	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs11864149 CA280401344	1211	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395502285 rs11864149	1211	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395502360 rs1462195686	1213	P>L		No	ClinGen gnomAD
RCV001351803 rs2069864656	1215	P>S		No	ClinVar dbSNP
CA7998617 rs758185749	1216	G>E		No	ClinGen ExAC gnomAD
rs781689890 CA7998618	1217	T>I		No	ClinGen ExAC gnomAD
CA395502468 rs1250871499	1218	L>V		No	ClinGen gnomAD
CA395502480 rs1417998961	1219	A>T		No	ClinGen gnomAD
CA7998621 rs778089235	1220	G>R		No	ClinGen ExAC TOPMed gnomAD
rs749828384 CA7998622	1221	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA280401364 rs1017750956	1221	R>W		No	ClinGen TOPMed gnomAD
CA395502541 rs1170637562	1222	R>K		No	ClinGen Ensembl
rs946432141 CA280401401	1223	S>A		No	ClinGen Ensembl
CA7998624 rs774537800	1224	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7998625 rs759740148	1224	R>H		No	ClinGen ExAC TOPMed gnomAD
CA280401437 rs926076191	1225	T>I		No	ClinGen TOPMed
rs772346371 CA7998626	1225	T>P		No	ClinGen ExAC gnomAD
rs926076191 CA395502604	1225	T>S		No	ClinGen TOPMed
rs760416360 CA7998628	1226	R>C		No	ClinGen ExAC TOPMed gnomAD
rs199646401 CA7998629 RCV000881590 COSM1197379	1226	R>H	lung [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs199646401 CA395502637	1226	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199646401 CA7998630	1226	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs760416360 CA395502617	1226	R>S		No	ClinGen ExAC TOPMed gnomAD
rs764643777 CA7998632	1228	S>F		No	ClinGen ExAC gnomAD
rs757989465 CA7998634	1229	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA7998633 rs3814882	1229	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395502730 rs1480117741	1230	A>P		No	ClinGen TOPMed gnomAD
rs1480117741 CA395502736	1230	A>S		No	ClinGen TOPMed gnomAD
CA395502724 rs1480117741	1230	A>T		No	ClinGen TOPMed gnomAD
rs751276891 CA7998636	1231	L>R		No	ClinGen ExAC gnomAD
CA7998638 rs778236519	1232	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7998637 rs746405927	1232	P>S		No	ClinGen ExAC TOPMed gnomAD
CA280401493 rs746405927	1232	P>T		No	ClinGen ExAC TOPMed gnomAD
CA7998642 rs549071207	1233	P>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs549071207 CA7998641	1233	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA7998640 rs549071207	1233	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395502900 rs772164234	1234	W>*		No	ClinGen ExAC gnomAD
CA7998643 rs772164234	1234	W>C		No	ClinGen ExAC gnomAD
rs1289089269 CA395502946	1236	R>E		No	ClinGen TOPMed
rs1289089269 CA395502944	1236	R>Q		No	ClinGen TOPMed
rs1304961608 CA395502950	1236	R>S		No	ClinGen gnomAD

No associated diseases with Q9UL54

3 regional properties for Q9UL54

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	28 - 281	IPR000719
active_site	Serine/threonine-protein kinase, active site	147 - 159	IPR008271
binding_site	Protein kinase, ATP binding site	34 - 58	IPR017441

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasmic vesicle membrane ; Multi-pass membrane protein Cytoplasm, cytoskeleton Nucleus	Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

13 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axonal growth cone	The migrating motile tip of a growing nerve cell axon.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendritic growth cone	The migrating motile tip of a growing nerve cell dendrite.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

9 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity	Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
mitogen-activated protein kinase kinase binding	Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.
neuropilin binding	Binding to a member of the neuropilin family.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activator activity	Binds to and increases the activity of a protein serine/threonine kinase.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
tau protein binding	Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
tau-protein kinase activity	Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.

25 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
activation of protein kinase activity	Any process that initiates the activity of an inactive protein kinase.
apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
axonogenesis	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
basal dendrite arborization	The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches.
basal dendrite morphogenesis	The process in which the anatomical structures of a basal dendrite are generated and organized.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
focal adhesion assembly	The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
mitotic G2 DNA damage checkpoint signaling	A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
neuron projection morphogenesis	The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
positive regulation of JNK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of protein autophosphorylation	Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
positive regulation of stress-activated MAPK cascade	Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.
protein autophosphorylation	The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation	The process of introducing a phosphate group on to a protein.
protein targeting to membrane	The process of directing proteins towards a membrane, usually using signals contained within the protein.
regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.
regulation of cell shape	Any process that modulates the surface configuration of a cell.
regulation of MAPK cascade	Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
stress-activated MAPK cascade	The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MPAGGRAGSL	KDPDVAELFF	KDDPEKLFSD	LREIGHGSFG	AVYFARDVRN	SEVVAIKKMS
70	80	90	100	110	120
YSGKQSNEKW	QDIIKEVRFL	QKLRHPNTIQ	YRGCYLREHT	AWLVMEYCLG	SASDLLEVHK
130	140	150	160	170	180
KPLQEVEIAA	VTHGALQGLA	YLHSHNMIHR	DVKAGNILLS	EPGLVKLGDF	GSASIMAPAN
190	200	210	220	230	240
SFVGTPYWMA	PEVILAMDEG	QYDGKVDVWS	LGITCIELAE	RKPPLFNMNA	MSALYHIAQN
250	260	270	280	290	300
ESPVLQSGHW	SEYFRNFVDS	CLQKIPQDRP	TSEVLLKHRF	VLRERPPTVI	MDLIQRTKDA
310	320	330	340	350	360
VRELDNLQYR	KMKKILFQEA	PNGPGAEAPE	EEEEAEPYMH	RAGTLTSLES	SHSVPSMSIS
370	380	390	400	410	420
ASSQSSSVNS	LADASDNEEE	EEEEEEEEEE	EEGPEAREMA	MMQEGEHTVT	SHSSIIHRLP
430	440	450	460	470	480
GSDNLYDDPY	QPEITPSPLQ	PPAAPAPTST	TSSARRRAYC	RNRDHFATIR	TASLVSRQIQ
490	500	510	520	530	540
EHEQDSALRE	QLSGYKRMRR	QHQKQLLALE	SRLRGEREEH	SARLQRELEA	QRAGFGAEAE
550	560	570	580	590	600
KLARRHQAIG	EKEARAAQAE	ERKFQQHILG	QQKKELAALL	EAQKRTYKLR	KEQLKEELQE
610	620	630	640	650	660
NPSTPKREKA	EWLLRQKEQL	QQCQAEEEAG	LLRRQRQYFE	LQCRQYKRKM	LLARHSLDQD
670	680	690	700	710	720
LLREDLNKKQ	TQKDLECALL	LRQHEATREL	ELRQLQAVQR	TRAELTRLQH	QTELGNQLEY
730	740	750	760	770	780
NKRREQELRQ	KHAAQVRQQP	KSLKVRAGQR	PPGLPLPIPG	ALGPPNTGTP	IEQQPCSPGQ
790	800	810	820	830	840
EAVLDQRMLG	EEEEAVGERR	ILGKEGATLE	PKQQRILGEE	SGAPSPSPQK	HGSLVDEEVW
850	860	870	880	890	900
GLPEEIEELR	VPSLVPQERS	IVGQEEAGTW	SLWGKEDESL	LDEEFELGWV	QGPALTPVPE
910	920	930	940	950	960
EEEEEEEGAP	IGTPRDPGDG	CPSPDIPPEP	PPTHLRPCPA	SQLPGLLSHG	LLAGLSFAVG
970	980	990	1000	1010	1020
SSSGLLPLLL	LLLLPLLAAQ	GGGGLQAALL	ALEVGLVGLG	ASYLLLCTAL	HLPSSLFLLL
1030	1040	1050	1060	1070	1080
AQGTALGAVL	GLSWRRGLMG	VPLGLGAAWL	LAWPGLALPL	VAMAAGGRWV	RQQGPRVRRG
1090	1100	1110	1120	1130	1140
ISRLWLRVLL	RLSPMAFRAL	QGCGAVGDRG	LFALYPKTNK	DGFRSRLPVP	GPRRRNPRTT
1150	1160	1170	1180	1190	1200
QHPLALLARV	WVLCKGWNWR	LARASQGLAS	HLPPWAIHTL	ASWGLLRGER	PTRIPRLLPR
1210	1220	1230
SQRQLGPPAS	RQPLPGTLAG	RRSRTRQSRA	LPPWR