AiPD: Autoinhibited Protein Database

Q9UHF5

Gene name	IL17B (IL20, NIRF, ZCYTO7, UNQ516/PRO1031)
Protein name	Interleukin-17B
Names	IL-17B, Cytokine Zcyto7, Interleukin-20, IL-20, Neuronal interleukin-17-related factor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:27190
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-72 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UHF5

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UHF5-F1	Predicted				AlphaFoldDB

161 variants for Q9UHF5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs201298520 CA129032405 RCV000491934	176	C>Y	Keratoconus 1 [ClinVar]	Yes	ClinGen ClinVar TOPMed dbSNP gnomAD
CA361688963 rs1368174581	2	D>H		No	ClinGen TOPMed gnomAD
CA361688937 rs1386970047	3	W>C		No	ClinGen gnomAD
CA3502224 rs767430336	3	W>R		No	ClinGen ExAC gnomAD
CA3502223 rs759701657	4	P>S		No	ClinGen ExAC gnomAD
CA3502222 CA3502221 rs147405895	5	H>Q		No	ClinGen ESP ExAC gnomAD
CA361688897 rs1581385684	6	N>T		No	ClinGen Ensembl
rs773686284 CA3502219	7	L>M		No	ClinGen ExAC TOPMed gnomAD
CA3502218 rs549065715	7	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA361688874 rs549065715	7	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs549065715 CA129036221	7	L>R		No	ClinGen 1000Genomes ExAC gnomAD
rs1338210953 CA361688285	8	L>V		No	ClinGen TOPMed gnomAD
CA361688267 rs1393291784	10	L>V		No	ClinGen TOPMed
CA361688261 rs1235093489	11	L>F		No	ClinGen TOPMed
CA361688242 rs1445926022	13	I>M		No	ClinGen TOPMed
rs964763233 CA129034620	13	I>N		No	ClinGen TOPMed gnomAD
CA361688249 rs1327699939	13	I>V		No	ClinGen TOPMed
TCGA novel	15	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA361688197 rs1318805759	18	G>W		No	ClinGen TOPMed
rs1336732947 CA361688179	20	G>D		No	ClinGen gnomAD
CA3502194 rs760361621	20	G>R		No	ClinGen ExAC TOPMed gnomAD
CA361688171 rs1335732972	21	Q>*		No	ClinGen TOPMed
rs1236760770 CA361688157	22	P>H		No	ClinGen TOPMed
rs774960128 CA3502193	22	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1457641169 CA361688134	24	S>N		No	ClinGen TOPMed
rs745736629 CA3502190	27	S>N		No	ClinGen ExAC TOPMed
rs140393797 CA129034525	30	K>N		No	ClinGen ESP TOPMed gnomAD
rs774358281 CA3502188	31	G>W		No	ClinGen ExAC gnomAD
CA3502186 rs147176226 CA3502187	33	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs750526618 CA3502184	34	R>L		No	ClinGen ExAC TOPMed gnomAD
rs750526618 CA3502183	34	R>Q		No	ClinGen ExAC TOPMed gnomAD
COSM449085 CA3502185 rs777464695	34	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1247776980 CA361687953	35	P>L		No	ClinGen gnomAD
CA361687962 rs1437210261	35	P>S		No	ClinGen gnomAD
CA361687942 rs1461352404	36	G>A		No	ClinGen TOPMed
rs750842286 CA3502180	37	P>R		No	ClinGen ExAC gnomAD
CA361687935 rs758559885	37	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758559885 CA3502181	37	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1354712962 CA361687883	41	G>V		No	ClinGen gnomAD
CA3502177 rs757523672	45	V>E		No	ClinGen ExAC gnomAD
rs1356282451 CA361687826	45	V>M		No	ClinGen TOPMed
CA361687796 rs1022123571	47	L>P		No	ClinGen gnomAD
rs1022123571 CA129034444	47	L>Q		No	ClinGen gnomAD
CA361687743 rs1325508134	49	L>Q		No	ClinGen gnomAD
CA3502174 rs760308405	51	S>*		No	ClinGen ExAC gnomAD
CA129034419 rs760308405	51	S>L		No	ClinGen ExAC gnomAD
rs147986476 CA3502172	52	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3502173 rs141618878	52	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA3502171 rs759108806	55	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1457832520 CA361687562	57	A>D		No	ClinGen gnomAD
rs566284760 CA3502168	58	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758090942 CA3502167	58	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs758090942 CA129034384	58	R>L		No	ClinGen ExAC TOPMed gnomAD
rs769775703 CA3502166	59	M>V		No	ClinGen ExAC TOPMed gnomAD
CA129034358 rs1041078298	60	E>Q		No	ClinGen TOPMed
CA361687488 rs1427644567	61	E>K		No	ClinGen TOPMed
CA3502163 rs772233379	62	Y>*		No	ClinGen ExAC gnomAD
rs144370508 CA3502164	62	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA361687446 rs149642401	63	E>D		No	ClinGen ESP gnomAD
rs778900330 CA3502161	67	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1302823208 CA361687323	71	A>V		No	ClinGen gnomAD
TCGA novel	73	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767580112 CA361687278 CA3502160	75	N>K		No	ClinGen ExAC TOPMed gnomAD
rs138372270 CA129034335	77	S>L		No	ClinGen ESP TOPMed gnomAD
CA3502159 rs754362858	80	A>G		No	ClinGen ExAC gnomAD
CA361687229 rs1298211375	80	A>T		No	ClinGen TOPMed
rs754362858 CA361687222	80	A>V		No	ClinGen ExAC gnomAD
rs547497109 CA3502158	81	Q>*		No	ClinGen 1000Genomes ExAC
rs368429899 CA3502156	82	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1212418175 CA361687175	85	E>*		No	ClinGen TOPMed
rs752296509 CA3502155	87	N>D		No	ClinGen ExAC TOPMed gnomAD
rs1393920867 CA361687149 COSM1435086	87	N>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1246932825 CA361687088	92	M>R		No	ClinGen gnomAD
CA361687064 rs1222698207	94	N>I		No	ClinGen TOPMed gnomAD
rs1222698207 CA361687066	94	N>S		No	ClinGen TOPMed gnomAD
CA361687052 rs1581383245	95	K>R		No	ClinGen Ensembl
TCGA novel	97	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765861023 CA3502151	100	P>S		No	ClinGen ExAC gnomAD
CA3502150 rs762941357	101	W>L		No	ClinGen ExAC gnomAD
rs140684808 CA3502149	102	G>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs749401276 CA3502119	104	S>R		No	ClinGen ExAC gnomAD
rs1581380850 CA361686324	106	N>T		No	ClinGen Ensembl
rs1581380840 CA361686305	107	H>P		No	ClinGen Ensembl
rs1408083911 CA361686260	108	D>A		No	ClinGen Ensembl
CA3502117 rs770259524	108	D>N		No	ClinGen ExAC gnomAD
CA361686239 rs1428034105	109	P>S		No	ClinGen gnomAD
CA361686209 rs1456560900	110	S>T		No	ClinGen gnomAD
rs748708206 CA3502116	111	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs373011468 CA3502115 COSM420839	111	R>H	urinary_tract Variant assessed as Somatic; 4.669e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA361686173 rs1581380783	112	I>T		No	ClinGen Ensembl
rs755299932 CA3502114	112	I>V		No	ClinGen ExAC gnomAD
rs746616674 CA3502113	113	P>L		No	ClinGen ExAC gnomAD
CA129032798 rs897120821	113	P>S		No	ClinGen TOPMed
rs757888351 CA361686121	114	V>L		No	ClinGen ExAC TOPMed gnomAD
CA3502111 rs757888351	114	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1401949675 CA361686099	115	D>A		No	ClinGen gnomAD
rs1401949675 CA361686097	115	D>G		No	ClinGen gnomAD
rs749925422 CA3502110	115	D>N		No	ClinGen ExAC gnomAD
CA3502109 rs764889728	117	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA129032747 rs896724282	118	E>*		No	ClinGen TOPMed
rs1433628359 CA361686002	119	A>P		No	ClinGen TOPMed
rs774590961 CA3502104	120	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs140917979 CA3502105	120	R>W	Variant assessed as Somatic; 0.0003246 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs766478963 CA3502103	121	C>R		No	ClinGen ExAC
rs1178036685 CA361685966	122	L>V		No	ClinGen gnomAD
rs763211165 CA3502102	123	C>R		No	ClinGen ExAC gnomAD
CA3502101 rs371293844	123	C>Y		No	ClinGen ESP ExAC gnomAD
rs1286144450 CA361685873	128	N>D		No	ClinGen TOPMed
CA3502099 rs748585346	128	N>K		No	ClinGen ExAC TOPMed
rs1223584193 CA361685865	128	N>S		No	ClinGen gnomAD
CA3502097 rs777015384	131	T>A		No	ClinGen ExAC TOPMed gnomAD
rs143579457 CA3502096	132	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA361685758 rs1237256981	132	M>T		No	ClinGen gnomAD
COSM39189 rs377701351 CA3502095	136	R>C	Variant assessed as Somatic; 0.0 impact. central_nervous_system prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA3502094 rs374213956	136	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA361685626 rs1175636470	137	S>C		No	ClinGen TOPMed
rs1388205581 CA361685602	138	M>T		No	ClinGen gnomAD
rs745574528 CA3502092	139	V>A		No	ClinGen ExAC TOPMed gnomAD
CA3502093 rs758105855	139	V>M		No	ClinGen ExAC gnomAD
rs778562390 CA3502091	140	S>G		No	ClinGen ExAC TOPMed gnomAD
CA3502089 rs753773022	141	V>G		No	ClinGen ExAC gnomAD
CA361685553 rs1438431060	141	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs367765361 CA3502088	142	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1321771243 CA361685516	143	V>A		No	ClinGen TOPMed gnomAD
CA3502086 rs752411869	143	V>L		No	ClinGen ExAC gnomAD
CA3502084 rs763153907	147	V>I		No	ClinGen ExAC gnomAD
CA3502083 rs773424096	150	R>C		No	ClinGen ExAC TOPMed gnomAD
rs765240048 CA3502082	150	R>H		No	ClinGen ExAC gnomAD
rs550871130 CA3502081	151	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202136839 CA3502080	151	R>H	Variant assessed as Somatic; 9.615e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs144395727 CA3502078	152	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs144395727 CA3502079	152	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201386909 CA129032546	152	R>H		No	ClinGen gnomAD
CA361685330 rs1289944604	153	L>P		No	ClinGen TOPMed
CA3502076 rs532107768	155	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1015717341 CA129032533	156	P>L		No	ClinGen TOPMed
CA3502072 rs149908263	157	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA3502073 rs147582010	157	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs752743282 CA3502069	159	R>C		No	ClinGen ExAC TOPMed gnomAD
rs138991563 CA3502067	159	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA3502066 rs754779395	162	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1191306380 CA361685177	163	C>*		No	ClinGen gnomAD
rs933815623 CA129032472	163	C>Y		No	ClinGen Ensembl
rs562575563 CA3502065	164	R>C		No	ClinGen ExAC TOPMed gnomAD
CA3502064 rs756453286	164	R>H		No	ClinGen ExAC TOPMed gnomAD
rs562575563 CA129032464	164	R>S		No	ClinGen ExAC TOPMed gnomAD
CA3502063 rs762063982	166	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1052840455 CA129032455	166	R>H		No	ClinGen TOPMed gnomAD
rs1052840455 CA361685135	166	R>P		No	ClinGen TOPMed gnomAD
rs528081511 CA3502061	167	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA361685083 rs1316986554	169	M>T		No	ClinGen gnomAD
rs1343037955 CA361685089	169	M>V		No	ClinGen TOPMed
rs1207553632 CA361685073	170	E>Q		No	ClinGen TOPMed
CA3502059 rs761086057	173	A>T		No	ClinGen ExAC TOPMed gnomAD
rs776072998 CA3502058	174	V>G		No	ClinGen ExAC gnomAD
rs1342876430 CA361685031	174	V>L		No	ClinGen gnomAD
rs1037161396 CA129032411	175	G>C		No	ClinGen gnomAD
CA361685017 rs1037161396	175	G>R		No	ClinGen gnomAD
rs1423263765 CA361684960	178	C>Y		No	ClinGen gnomAD
CA3502055 rs774894146	179	I>V		No	ClinGen ExAC gnomAD
rs770682054 CA3502054	181	F>C		No	ClinGen ExAC

No associated diseases with Q9UHF5

1 regional properties for Q9UHF5

Type	Name	Position	InterPro Accession
conserved_site	Short-chain dehydrogenase/reductase, conserved site	197 - 225	IPR020904

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

1 GO annotations of cellular component

Name	Definition
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

1 GO annotations of molecular function

Name	Definition
cytokine activity	The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells.

4 GO annotations of biological process

Name	Definition
cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
positive regulation of cytokine production involved in inflammatory response	Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MDWPHNLLFL	LTISIFLGLG	QPRSPKSKRK	GQGRPGPLAP	GPHQVPLDLV	SRMKPYARME
70	80	90	100	110	120
EYERNIEEMV	AQLRNSSELA	QRKCEVNLQL	WMSNKRSLSP	WGYSINHDPS	RIPVDLPEAR
130	140	150	160	170
CLCLGCVNPF	TMQEDRSMVS	VPVFSQVPVR	RRLCPPPPRT	GPCRQRAVME	TIAVGCTCIF