AiPD: Autoinhibited Protein Database

Q9UD71

Gene name	PPP1R1B (DARPP32)
Protein name	Protein phosphatase 1 regulatory subunit 1B
Names	DARPP-32, Dopamine- and cAMP-regulated neuronal phosphoprotein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:84152
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-152 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

4-152 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q9UD71

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9UD71-F1	Predicted				AlphaFoldDB

157 variants for Q9UD71

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA290410891 rs952716568	4	K>E		No	ClinGen Ensembl
CA399262701 rs547648169	6	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs547648169 CA8531939	6	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761179656 CA8531940	7	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1161651631 CA399262754	9	I>L		No	ClinGen gnomAD
CA399262780 rs1371861232	10	Q>P		No	ClinGen gnomAD
rs1309734047 CA399262812	11	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1415111106 CA399262806	11	F>S		No	ClinGen TOPMed gnomAD
rs1462084175 CA399262830	12	S>L		No	ClinGen gnomAD
CA8531941 rs766668979	14	P>L		No	ClinGen ExAC gnomAD
CA290410897 rs961996489	16	P>L		No	ClinGen Ensembl
CA290410896 rs1016171854	16	P>S		No	ClinGen Ensembl
CA399262905 rs1398117032	17	P>L		No	ClinGen gnomAD
rs1337810833 CA399262916	18	S>G		No	ClinGen gnomAD
rs971883980 CA399262932 CA290410899	18	S>R		No	ClinGen TOPMed gnomAD
CA399262954 rs1244407066	19	Q>R		No	ClinGen gnomAD
rs779075907 CA8531944	21	D>E		No	ClinGen ExAC TOPMed gnomAD
CA8531943 rs755222458	21	D>G		No	ClinGen ExAC gnomAD
TCGA novel	23	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399263136 rs1243509329	26	E>D		No	ClinGen gnomAD
rs1460757564 CA399263141	27	M>L		No	ClinGen gnomAD
CA8531963 rs367543179	29	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA225905 rs367543179 RCV000084768	29	R>Q		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1304514528 CA399263646	29	R>W		No	ClinGen TOPMed
rs756069251 CA8531964	30	R>C		No	ClinGen ExAC
CA8531965 rs780007110	30	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1468522759 CA399263714	31	R>M		No	ClinGen gnomAD
TCGA novel	32	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs971270763 CA290411301	33	P>L		No	ClinGen TOPMed gnomAD
CA399263784 rs1346245001	34	T>M		No	ClinGen gnomAD
rs1287695645 CA399263849	36	A>D		No	ClinGen gnomAD
CA8531967 rs368811507	40	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1405677322 CA399263937	40	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs778787065 CA8531968	42	S>L		No	ClinGen ExAC gnomAD
rs775936429 CA399264438	50	E>D		No	ClinGen ExAC gnomAD
CA8531993 rs201594054	51	A>D		No	ClinGen ExAC TOPMed gnomAD
rs201594054 CA399264496	51	A>G		No	ClinGen ExAC TOPMed gnomAD
rs201594054 CA399264478	51	A>V		No	ClinGen ExAC TOPMed gnomAD
CA399264502 rs1337240564	52	S>T		No	ClinGen TOPMed
CA399264521 rs1434278389	52	S>Y		No	ClinGen TOPMed
rs1567847557 CA399264536	53	P>A		No	ClinGen Ensembl
rs145932715 CA399264572	54	H>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145932715 CA8531995	54	H>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1383457396	54	H>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290411400 rs896774899	55	Q>E		No	ClinGen Ensembl
CA399264903 rs1201825976	56	R>T		No	ClinGen TOPMed gnomAD
TCGA novel	57	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8532018 rs774523933	61	G>R		No	ClinGen ExAC gnomAD
CA399265113 rs1470088091	63	H>R		No	ClinGen gnomAD
CA8532019 rs377425724	64	L>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA399265227 rs1399902677	66	S>A		No	ClinGen gnomAD
COSM978639 rs200974893 CA8532020	66	S>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA399265373 rs1159938127	70	N>Y		No	ClinGen TOPMed gnomAD
CA8532022 rs199925027	71	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs140199436 CA290411536	72	C>R		No	ClinGen ESP
rs1032368917 CA290411538	72	C>Y		No	ClinGen TOPMed
CA399265626 rs1284755691	75	T>I		No	ClinGen gnomAD
CA290411542 rs922146710	78	S>L		No	ClinGen TOPMed gnomAD
CA8532045 rs751406867	81	A>G		No	ClinGen ExAC gnomAD
rs1392259387 CA399267686	82	V>M		No	ClinGen gnomAD
CA8532047 rs767247081	84	R>C		No	ClinGen ExAC TOPMed gnomAD
rs139360619 CA8532049 COSM705328	84	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs139360619 CA8532050	84	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8532048 rs767247081	84	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1253254924 CA399267979	93	I>L		No	ClinGen gnomAD
rs1253254924 CA399267981	93	I>V		No	ClinGen gnomAD
CA399268069 rs1597781172	95	N>S		No	ClinGen Ensembl
TCGA novel	97	N>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1237330238 CA399268263	100	Q>H		No	ClinGen gnomAD
CA8532055 rs758721684	101	A>V		No	ClinGen ExAC TOPMed gnomAD
CA399268305 rs1185321761	103	E>K		No	ClinGen gnomAD
CA8532056 rs778216588	104	E>G		No	ClinGen ExAC gnomAD
CA399268421 rs1162095494	105	E>D		No	ClinGen gnomAD
rs747247652 CA8532057	105	E>K		No	ClinGen ExAC gnomAD
CA399268512 rs1374379241	107	E>G		No	ClinGen gnomAD
rs1597781212 CA399268576	109	G>R		No	ClinGen Ensembl
CA399268603 rs1167030170	109	G>V		No	ClinGen gnomAD
CA8532059 rs776915939	110	E>D		No	ClinGen ExAC gnomAD
CA399268678 rs1262166630	112	R>P		No	ClinGen TOPMed
rs1262166630 CA399268675	112	R>Q		No	ClinGen TOPMed
rs934858687 CA290413032	112	R>W		No	ClinGen TOPMed
rs1239288175 CA399268695	113	E>K		No	ClinGen TOPMed
CA8532060 rs745902423	116	Y>N		No	ClinGen ExAC gnomAD
rs1394300459 CA399268790	119	E>K		No	ClinGen gnomAD
CA399268865 rs1297838615	121	D>G		No	ClinGen gnomAD
CA8532063 rs768685523	122	E>K		No	ClinGen ExAC gnomAD
CA399268944 rs1226964800	123	E>D		No	ClinGen gnomAD
rs922722288 CA290413046	125	E>K		No	ClinGen Ensembl
rs144685420 CA8532067	126	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed
CA8532065 rs774173341	126	E>G		No	ClinGen ExAC TOPMed gnomAD
CA8532068 rs767316801	127	D>E		No	ClinGen ExAC TOPMed gnomAD
CA399269043 rs1567849504	128	D>E		No	ClinGen Ensembl
rs747625780 CA290413057	129	E>D		No	ClinGen ExAC gnomAD
TCGA novel	131	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765988806 CA8532074	131	E>K		No	ClinGen ExAC gnomAD
CA8532076 rs754471109	133	E>A		No	ClinGen ExAC TOPMed gnomAD
CA399269155 rs1263214759	133	E>K		No	ClinGen gnomAD
TCGA novel	138	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399269345 rs1421049807	139	A>D		No	ClinGen gnomAD
CA8532078 rs753149836	142	L>P		No	ClinGen ExAC gnomAD
TCGA novel	143	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA290413077 rs888452883	144	V>L		No	ClinGen Ensembl
rs371198090 CA8532080	145	I>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs180955049 CA8532081	146	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381740448 CA399269574	147	Q>H		No	ClinGen gnomAD
rs757592685 CA8532082	148	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA8532104 rs756349197	149	A>G		No	ClinGen ExAC gnomAD
CA399269594 rs1171470511	149	A>T		No	ClinGen gnomAD
rs780069107 CA8532105	151	Q>R		No	ClinGen ExAC gnomAD
rs1179319652 CA399270899	152	K>Q		No	ClinGen gnomAD
CA399270957 rs1597782674	153	T>A		No	ClinGen Ensembl
rs946950591 CA290413576	153	T>K		No	ClinGen TOPMed gnomAD
CA8532107 rs142405059	156	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1597782695 CA399271088	159	L>P		No	ClinGen Ensembl
CA290413578 rs923563706	160	E>G		No	ClinGen TOPMed
rs867953055 CA290413588	164	E>K		No	ClinGen Ensembl
CA8532110 COSM2156691 rs367543181	165	R>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA399271247 rs1433950150	165	R>H		No	ClinGen gnomAD
RCV000084770 rs367543181 CA225909	165	R>S		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA8532112 rs759168684	167	P>H		No	ClinGen ExAC gnomAD
rs75805989 CA8532111	167	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA290413595 rs75805989	167	P>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8532113 rs201468603	168	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201468603 CA8532115	168	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201468603 CA8532114	168	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1307049040 CA399271330	169	L>V		No	ClinGen gnomAD
CA399271364 rs1360953726	170	D>E		No	ClinGen gnomAD
rs142312063 CA290413612	173	E>*		No	ClinGen ESP TOPMed gnomAD
rs762341431 CA8532118	173	E>D		No	ClinGen ExAC gnomAD
rs142312063 CA290413609	173	E>K		No	ClinGen ESP TOPMed gnomAD
rs767783990 CA8532119	174	R>K		No	ClinGen ExAC gnomAD
rs112102104 CA8532120	176	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8532121 rs756335286	177	G>S		No	ClinGen ExAC gnomAD
rs1238949710 CA399271536	179	E>K		No	ClinGen TOPMed
rs1238949710 CA399271540	179	E>Q		No	ClinGen TOPMed
rs754012099 CA8532123	180	D>G		No	ClinGen ExAC TOPMed gnomAD
CA399271578 rs754012099	180	D>V		No	ClinGen ExAC TOPMed gnomAD
CA399271631 rs778899903	181	Q>H		No	ClinGen ExAC gnomAD
rs746964011 CA8532126	184	D>N		No	ClinGen ExAC TOPMed gnomAD
CA399271787 rs1171477074	186	A>E		No	ClinGen TOPMed gnomAD
CA290413631 rs960744652	187	L>V		No	ClinGen gnomAD
CA399272056 rs1210795207	191	G>A		No	ClinGen TOPMed
CA8532142 rs755137721	194	P>S		No	ClinGen ExAC TOPMed gnomAD
CA290413677 rs562428995	195	Q>R		No	ClinGen Ensembl
CA8532143 COSM4129947 rs35797948	196	R>H	thyroid [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs910863560 CA290413681	197	P>A		No	ClinGen TOPMed
CA290413692 rs79497069	198	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399272297 rs1356907425	198	S>T		No	ClinGen gnomAD
rs79497069 RCV000955271 CA8532144	198	S>Y		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs757180713 CA8532145	199	P>H		No	ClinGen ExAC gnomAD
rs757180713 CA290413698	199	P>L		No	ClinGen ExAC gnomAD
rs535690693 CA8532146	200	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1217122660 CA399272347	200	S>C		No	ClinGen gnomAD
CA8532148 rs745743199	203	G>R		No	ClinGen ExAC gnomAD
rs745743199 CA8532147	203	G>S		No	ClinGen ExAC gnomAD
rs1388739789 CA399272512	204	T>I		No	ClinGen TOPMed
rs779924792 CA8532149	205	T>Q		No	ClinGen ExAC gnomAD

No associated diseases with Q9UD71

No regional properties for Q9UD71

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9UD71

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
cAMP-dependent protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
protein kinase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein phosphatase inhibitor activity	Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.
protein phosphatase regulator activity	Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

11 GO annotations of biological process

Name	Definition
behavioral response to cocaine	Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
cellular response to cocaine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
DNA-templated transcription	The synthesis of an RNA transcript from a DNA template.
intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
negative regulation of female receptivity	Any process that stops, prevents or reduces the receptiveness of a female to male advances.
negative regulation of phosphoprotein phosphatase activity	Any process that stops or reduces the activity of a phosphoprotein phosphatase.
response to amphetamine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
response to morphine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual learning	Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MDPKDRKKIQ	FSVPAPPSQL	DPRQVEMIRR	RRPTPAMLFR	LSEHSSPEEE	ASPHQRASGE
70	80	90	100	110	120
GHHLKSKRPN	PCAYTPPSLK	AVQRIAESHL	QSISNLNENQ	ASEEEDELGE	LRELGYPREE
130	140	150	160	170	180
DEEEEEDDEE	EEEEEDSQAE	VLKVIRQSAG	QKTTCGQGLE	GPWERPPPLD	ESERDGGSED
190	200
QVEDPALSEP	GEEPQRPSPS	EPGT