AiPD: Autoinhibited Protein Database

Q9UBW8

Gene name	COPS7A (CSN7A, DERP10)
Protein name	COP9 signalosome complex subunit 7a
Names	SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a
Species	Homo sapiens (Human)
KEGG Pathway	hsa:50813
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

193-270 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

193-270 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q9UBW8

Entry ID	Method	Resolution	Chain	Position	Source
4D10	X-ray	380 A	G/O	1-218	PDB
4D18	X-ray	408 A	G/O	1-218	PDB
4WSN	X-ray	550 A	G/O/W/e/m/u	1-218	PDB
AF-Q9UBW8-F1	Predicted				AlphaFoldDB

173 variants for Q9UBW8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA383667402 rs1443442005	2	S>N		No	ClinGen TOPMed
CA6414426 rs550314669	4	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA6414428 rs769414634	7	V>M		No	ClinGen ExAC
CA383667465 rs1442791272	11	N>K		No	ClinGen gnomAD
rs1422971398 CA383667476	13	E>Q		No	ClinGen gnomAD
TCGA novel	15	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6414431 rs765860750	16	L>Q		No	ClinGen ExAC gnomAD
CA383667517 rs1438828117	19	A>G		No	ClinGen TOPMed
rs753187213 CA6414432	23	K>N		No	ClinGen ExAC TOPMed gnomAD
CA383667544 rs1419984174	23	K>R		No	ClinGen gnomAD
CA383667548 rs1319366838	24	G>R		No	ClinGen TOPMed gnomAD
TCGA novel	25	A>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761088141 CA6414433	28	A>T		No	ClinGen ExAC
rs754279549 CA6414435	31	I>L		No	ClinGen ExAC gnomAD
CA6414436 rs754279549	31	I>V		No	ClinGen ExAC gnomAD
CA6414437 rs779249197	32	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1170430701 CA383667607	34	V>M		No	ClinGen gnomAD
rs1337649776 CA383667618	36	E>K		No	ClinGen TOPMed gnomAD
CA383667626 rs1227080446	37	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs904143307 CA232394106	39	G>D		No	ClinGen Ensembl
rs904143307 CA383667641	39	G>V		No	ClinGen Ensembl
CA232394116 rs145508491	40	V>I		No	ClinGen ESP TOPMed gnomAD
TCGA novel	45	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383667676 rs1466751100	45	E>K		No	ClinGen TOPMed
TCGA novel	46	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1205701276 CA383667692	47	L>P		No	ClinGen TOPMed
rs1482824393 CA383667698	48	D>G		No	ClinGen gnomAD
CA6414441 rs148833801	49	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA383667715 rs1348264306	50	P>L		No	ClinGen TOPMed
rs1471605273 CA383667720	51	N>S		No	ClinGen gnomAD
TCGA novel	53	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768498031 CA6414442	53	R>S		No	ClinGen ExAC
CA383667737 rs1396271960	54	E>K		No	ClinGen gnomAD
rs1396271960 CA383667738	54	E>Q		No	ClinGen gnomAD
CA6414487 rs748627485	61	A>D		No	ClinGen ExAC gnomAD
CA6414486 rs775145801	61	A>T		No	ClinGen ExAC gnomAD
rs1173182050 CA383667805	62	S>A		No	ClinGen TOPMed gnomAD
rs1173182050 CA383667804	62	S>P		No	ClinGen TOPMed gnomAD
CA383667822 rs1436308113	64	F>L		No	ClinGen gnomAD
CA383667824 rs1395746588	65	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA232396230 rs1032124527	65	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA232396232 rs988348156	68	T>A		No	ClinGen TOPMed
CA6414489 rs773894715	68	T>I		No	ClinGen ExAC gnomAD
CA232396239 rs984561566	69	V>G		No	ClinGen gnomAD
rs1232093629 CA383667866	72	Y>F		No	ClinGen gnomAD
CA6414491 rs771384634	76	A>G		No	ClinGen ExAC gnomAD
rs1426899488 CA383667891	76	A>T		No	ClinGen gnomAD
CA232396245 rs907732925	80	A>T		No	ClinGen Ensembl
CA6414511 rs141811786	80	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA232396313 rs1023271179	83	R>G		No	ClinGen Ensembl
CA232396320 rs147088395	83	R>Q		No	ClinGen ESP TOPMed gnomAD
CA232396318 rs1023271179	83	R>W		No	ClinGen Ensembl
CA383667962 rs1186837069	84	N>S		No	ClinGen gnomAD
rs1470045521 CA383667960	84	N>Y		No	ClinGen gnomAD
CA6414513 rs759703229	87	P>S		No	ClinGen ExAC gnomAD
rs1172487794 CA383667993	88	L>V		No	ClinGen TOPMed gnomAD
CA383668004 rs1366688614	89	T>I		No	ClinGen gnomAD
rs1316426804 CA383668005	90	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs775733098 CA6414515	93	K>M		No	ClinGen ExAC gnomAD
rs1396031595 CA383668057	97	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs764220895 CA6414517	97	R>L		No	ClinGen ExAC TOPMed gnomAD
rs764220895 CA6414518 COSM942831	97	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6414519 rs761815242	98	H>L		No	ClinGen ExAC gnomAD
rs764902554 CA6414520	99	L>P		No	ClinGen ExAC gnomAD
rs1213800724 CA383668077	101	V>I		No	ClinGen gnomAD
rs1014678820 CA232396350	102	V>A		No	ClinGen Ensembl
rs1383164724 CA383668083	102	V>I		No	ClinGen gnomAD
rs758306221 CA6414522	108	V>I		No	ClinGen ExAC gnomAD
CA383668147 rs1225700951	110	C>Y		No	ClinGen gnomAD
rs1347384881 CA383668162	112	P>S		No	ClinGen gnomAD
rs1282178428 CA383668169	113	Y>C		No	ClinGen gnomAD
CA6414556 rs773225678	115	V>L		No	ClinGen ExAC TOPMed gnomAD
CA232396881 rs773225678	115	V>M		No	ClinGen ExAC TOPMed gnomAD
CA6414558 rs766236035	118	E>K		No	ClinGen ExAC gnomAD
TCGA novel	119	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759297834 CA6414560	120	L>P		No	ClinGen ExAC gnomAD
CA6414559 rs375333384	120	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs376041428 CA6414564	123	R>C		No	ClinGen ExAC gnomAD
COSM942832 rs141939720 CA6414565	123	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA383668246 rs1328709798	126	R>L		No	ClinGen gnomAD
CA232396908 rs994542399	131	L>F		No	ClinGen TOPMed
CA383668301 rs1323942671	134	E>D		No	ClinGen gnomAD
rs1444503147 CA383668294	134	E>K		No	ClinGen gnomAD
rs780351989 CA6414567	136	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1441908358 CA383668317	137	Y>C		No	ClinGen gnomAD
rs755340818 CA6414569	140	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA6414570 rs201931813	142	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6414571 rs367999302	142	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs769841560 CA6414572	144	S>F		No	ClinGen ExAC gnomAD
rs1251821808 CA383668364	145	L>P		No	ClinGen gnomAD
CA383668365 rs1251821808	145	L>R		No	ClinGen gnomAD
CA6414573 rs778026596	148	R>C		No	ClinGen ExAC gnomAD
CA6414574 rs749187916	148	R>H		No	ClinGen ExAC gnomAD
CA6414576 rs542557133	151	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1202082 rs770968363 CA6414575	151	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA6414577 rs759373158	152	L>F		No	ClinGen ExAC gnomAD
CA383668413 rs1592471730	153	E>A		No	ClinGen Ensembl
CA383668411 rs1592471724	153	E>Q		No	ClinGen Ensembl
rs1592471747 CA383668423	154	V>G		No	ClinGen Ensembl
CA383668457 rs1162958350	159	G>R		No	ClinGen gnomAD
rs1441931837 CA383668464	160	R>L		No	ClinGen gnomAD
CA383668465 rs1441931837	160	R>Q		No	ClinGen gnomAD
CA383668472 rs1328113147	161	D>E		No	ClinGen gnomAD
TCGA novel	162	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs989349484 CA232396972	163	Q>R		No	ClinGen TOPMed gnomAD
COSM179567 CA6414582 rs770890062	164	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs146292223 COSM942834 CA6414583	164	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs146292223 CA6414584	164	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6414585 rs766842646	165	Q>P		No	ClinGen ExAC gnomAD
rs144729591 CA6414586	169	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA383668526 rs1215205178	170	I>V		No	ClinGen gnomAD
CA383668533 rs1281654126	171	A>S		No	ClinGen gnomAD
rs781411141 CA6414588	172	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs752921004 CA6414589	172	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1565468878 CA383668913	178	C>R		No	ClinGen Ensembl
CA383668970 rs1376011231	183	V>I		No	ClinGen TOPMed gnomAD
rs758294402 CA6414614	184	V>A		No	ClinGen ExAC gnomAD
CA6414613 rs144125600	184	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA6414615 rs780092140	185	L>M		No	ClinGen ExAC gnomAD
CA6414618 rs371945691	186	S>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs1565468926 CA383669032	188	I>T		No	ClinGen Ensembl
CA232397723 rs368792700	193	S>T		No	ClinGen Ensembl
CA383669111 rs1486287009	194	R>C		No	ClinGen gnomAD
CA6414621 rs146030026	194	R>H		No	ClinGen ESP ExAC gnomAD
CA6414623 rs767878807	196	N>S		No	ClinGen ExAC TOPMed gnomAD
CA383669144 rs1246773176	197	Q>K		No	ClinGen TOPMed
CA383669159 rs1340823601	198	H>Y		No	ClinGen TOPMed
rs764568975 CA6414626	200	E>K		No	ClinGen ExAC TOPMed gnomAD
rs971349850 CA232397748	204	G>S		No	ClinGen TOPMed gnomAD
rs1467577283 CA383669298	208	Q>*		No	ClinGen gnomAD
TCGA novel	209	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383669339 rs1592473327	211	S>R		No	ClinGen Ensembl
CA383669397 rs1249309027	214	A>V		No	ClinGen gnomAD
TCGA novel	219	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	219	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383669481 rs1326368978	221	K>E		No	ClinGen gnomAD
CA383669515 rs1332744385 COSM1363859	223	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA232397817 rs1054593291	223	T>S		No	ClinGen gnomAD
rs758397165 CA6414651	224	T>M		No	ClinGen ExAC TOPMed gnomAD
rs1184575046 CA383669538	225	A>V		No	ClinGen gnomAD
rs148675442 CA6414653	229	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA232397826 rs148675442	229	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6414654 rs148675442	229	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA6414655 rs549562987	231	T>A		No	ClinGen 1000Genomes ExAC gnomAD
rs1474575342 CA383669622	233	Q>*		No	ClinGen gnomAD
rs1472033303 CA383669625	233	Q>P		No	ClinGen TOPMed
CA383669703 rs1592473690	238	H>P		No	ClinGen Ensembl
rs752457696 CA383669711	238	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1001415163 CA383669748	242	L>P		No	ClinGen TOPMed gnomAD
CA232397854 rs1001415163	242	L>R		No	ClinGen TOPMed gnomAD
rs1384687161 CA383669754	243	R>K		No	ClinGen gnomAD
CA383669785 rs1592473765	245	P>L		No	ClinGen Ensembl
rs748981640 CA6414659	246	A>S		No	ClinGen ExAC gnomAD
rs1565469245 CA383669805	247	P>L		No	ClinGen Ensembl
CA232397870 rs866770862	247	P>S		No	ClinGen Ensembl
CA6414660 rs770280665	248	G>S		No	ClinGen ExAC gnomAD
rs373193931 CA6414661	249	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA383669821 rs1348729430	249	T>S		No	ClinGen TOPMed
rs1034263531 CA232397881	250	N>H		No	ClinGen Ensembl
rs1313456811 CA383669835	250	N>S		No	ClinGen gnomAD
TCGA novel	251	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6414662 rs747470345	252	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1213903912 CA383669871	253	Q>*		No	ClinGen gnomAD
rs777322286 CA6414664	254	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6414663 rs769264964	254	P>S		No	ClinGen ExAC gnomAD
CA232397900 rs973901065	256	K>R		No	ClinGen gnomAD
rs1485274845 CA383669918	258	A>T		No	ClinGen TOPMed gnomAD
rs774622741 CA6414695	264	L>I		No	ClinGen ExAC TOPMed gnomAD
CA232398022 rs151177416	265	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
rs370260459 COSM942835 CA6414699	268	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1322441569 CA383670160	269	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA383670220 rs1325522072	274	S>T		No	ClinGen TOPMed
CA6414703 rs757043808	276	N>W		No	ClinGen ExAC

No associated diseases with Q9UBW8

2 regional properties for Q9UBW8

Type	Name	Position	InterPro Accession
domain	Proteasome component (PCI) domain	1 - 177	IPR000717
domain	COP9 signalosome complex subunit 7, helix I	166 - 215	IPR041481

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
COP9 signalosome	A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

4 GO annotations of biological process

Name	Definition
COP9 signalosome assembly	The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome.
protein deneddylation	The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein neddylation	Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.
regulation of protein neddylation	Any process that modulates the frequency, rate or extent of protein neddylation.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MSAEVKVTGQ	NQEQFLLLAK	SAKGAALATL	IHQVLEAPGV	YVFGELLDMP	NVRELAESDF
70	80	90	100	110	120
ASTFRLLTVF	AYGTYADYLA	EARNLPPLTE	AQKNKLRHLS	VVTLAAKVKC	IPYAVLLEAL
130	140	150	160	170	180
ALRNVRQLED	LVIEAVYADV	LRGSLDQRNQ	RLEVDYSIGR	DIQRQDLSAI	ARTLQEWCVG
190	200	210	220	230	240
CEVVLSGIEE	QVSRANQHKE	QQLGLKQQIE	SEVANLKKTI	KVTTAAAAAA	TSQDPEQHLT
250	260	270
ELREPAPGTN	QRQPSKKASK	GKGLRGSAKI	WSKSN