Q9U6A9

PR
Gene name
NOG1
Protein name
Nucleolar GTP-binding protein 1
Names
Species
Trypanosoma brucei brucei
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

475-653 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9U6A9

Entry ID Method Resolution Chain Position Source
AF-Q9U6A9-F1 Predicted AlphaFoldDB

No variants for Q9U6A9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9U6A9

No associated diseases with Q9U6A9

7 regional properties for Q9U6A9

Type Name Position InterPro Accession
domain GTP binding domain 172 - 192 IPR006073-1
domain GTP binding domain 193 - 211 IPR006073-2
domain GTP binding domain 220 - 235 IPR006073-3
domain Nucleolar GTP-binding protein 1, Rossman-fold domain 237 - 293 IPR010674
domain NOG, C-terminal 400 - 453 IPR012973
domain OBG-type guanine nucleotide-binding (G) domain 170 - 342 IPR031167
domain NOG1, N-terminal helical domain 7 - 166 IPR041623

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.

1 GO annotations of biological process

Name Definition
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTIYNFKTV TVVPSYKDFI DIVLSKTQRK TPTVVHKGYH ISRIRQFYMR KVKFTQKTIN
70 80 90 100 110 120
EKLTHILTEF PRMDDIHPFY GDLMHVLYDR DHYKVALGQV GAVRHMVDNV GRDYVRLLKY
130 140 150 160 170 180
GDSLYRCKQL KRAALGRMAT ACKKLTSALV YLEKVRQHMS RLPSIDPNAR TLLITGFPNV
190 200 210 220 230 240
GKSSFMNKVT RADVEVQPYA FTTKSLFVGH TDFKYASWQV IDTPGILDHS LEERNVIEMQ
250 260 270 280 290 300
AITALAHLRA CILFFMDLST QCGHSIAQQV SLFKSIGPLF TGKPVIVVFN KSDLCTFDDI
310 320 330 340 350 360
TAEEQSLVMT AIEECGAKWI TTSTLTDAGV GDLKTLACET LLAHRSEQKE GSGRFQAIQN
370 380 390 400 410 420
RLYCAVPQKR DNVERPAYVP PSVEEIRQRL ASGEPVRERR KTERDYEWEN GGPGQYQPNE
430 440 450 460 470 480
RKTWDLENPE WVDDIIPDIM DGHNIYDNVD PDIHERLMEL EAEEDARLQE LELEASKKRP
490 500 510 520 530 540
QYELHDSTVE AVRFIRDKIK VIKMERAMKN PSLRRTRRQS VAIEKFNKRT GSQVDRSATP
550 560 570 580 590 600
GCSSETTNSS AKRGRSLSAA QEAVMRDRSS SHMSTKTTRG ISSHSATRDR SLSVNRGEGY
610 620 630 640 650
RDVNEKLRAV KLSKVVARPR NLQAKKGEGD RAIPNLRPKH LFTGKVKSNG RRDRR