Q9TUP7

PR
Gene name
HCRTR2
Protein name
Orexin receptor type 2
Names
Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:399545
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-323 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9TUP7

Entry ID Method Resolution Chain Position Source
AF-Q9TUP7-F1 Predicted AlphaFoldDB

1 variants for Q9TUP7

Variant ID(s) Position Change Description Diseaes Association Provenance
54 E>K narcolepsy; autosomal recessive; loss of function [UniProt] No

No associated diseases with Q9TUP7

3 regional properties for Q9TUP7

Type Name Position InterPro Accession
domain Ribosomal protein L30, N-terminal 13 - 84 IPR012988
domain Ribosomal protein L30, ferredoxin-like fold domain 89 - 139 IPR016082
domain Ribosomal protein L7, eukaryotic/archaeal 88 - 247 IPR035808

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
orexin receptor activity Combining with orexin to initiate a change in cell activity.

8 GO annotations of biological process

Name Definition
circadian sleep/wake cycle process A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.
feeding behavior Behavior associated with the intake of food.
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
locomotion Self-propelled movement of a cell or organism from one location to another.
neuropeptide signaling pathway A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
phospholipase C-activating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
regulation of circadian sleep/wake cycle, wakefulness Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep.
regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P58308 Hcrtr2 Orexin receptor type 2 Mus musculus (Mouse) PR
P56719 Hcrtr2 Orexin receptor type 2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MSGTKLEDSP PCRNWSSAPE LNETQEPFLN PTDYDDEEFL RYLWREYLHP KEYEWVLIAG
70 80 90 100 110 120
YIIVFVVALV GNVLVCVAVW KNHHMRTVTN YFIVNLSLAD VLVTITCLPA TLVVDITETW
130 140 150 160 170 180
FFGQSLCKVI PYLQTVSVSV SVLTLSCIAL DRWYAICHPL MFKSTAKRAR NSIVIIWIVS
190 200 210 220 230 240
CIIMIPQAIV MECSTMLPGL ANKTTLFTVC DERWGGEIYP KMYHICFFLV TYMAPLCLMV
250 260 270 280 290 300
LAYLQIFRKL WCRQIPGTSS VVQRKWKPLQ PASQPRGPGQ QTKSRISAVA AEIKQIRARR
310 320 330 340 350 360
KTARMLMVVL LVFAICYLPI SILNVLKRVF GMFTHTEDRE TVYAWFTFSH WLVYANSAAN
370 380 390 400 410 420
PIIYNFLSGK FREEFKAAFS CCCLGVHHRQ EDRLTRGRTS TESRKSLTTQ ISNFDNVSKL
430 440
SEQVVLTSIS TLPAANGAGP LQNW