Q9TTK0

PR
Gene name
CDKL2
Protein name
Cyclin-dependent kinase-like 2
Names
Serine/threonine-protein kinase KKIAMRE
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008614
EC number
2.7.11.22: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-566 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

143-166 (Activation loop from InterPro)

Target domain

4-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9TTK0

Entry ID Method Resolution Chain Position Source
AF-Q9TTK0-F1 Predicted AlphaFoldDB

No variants for Q9TTK0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TTK0

No associated diseases with Q9TTK0

3 regional properties for Q9TTK0

Type Name Position InterPro Accession
domain Protein kinase domain 349 - 640 IPR000719
active_site Serine/threonine-protein kinase, active site 469 - 481 IPR008271
domain Cyclin-dependent kinase 11/PITSLRE, catalytic domain 343 - 640 IPR045267

Functions

Description
EC Number 2.7.11.22 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH
70 80 90 100 110 120
ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDD QVVQKYLFQI INGIGFCHSH
130 140 150 160 170 180
NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG
190 200 210 220 230 240
KAVDVWAIGC LVTEMLMGEP LFPGDSDIDQ LYLIMRCLGN LIPRHQELFY KNPVFAGVRL
250 260 270 280 290 300
PEIKESEPLE RRYPKLSEVV IDLAKKCLHV DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350 360
QMKVQKDARN ISLSKKSQNR KKEKEKDDSL GEERKTLVVQ DTNVDSKFKD SKVFKIKGSK
370 380 390 400 410 420
IDGEKVDKGN RAAVSMTVGP SHIKAVPSTS LRDCSNVSVD HTRNPGMAIP PLTHNLSAVA
430 440 450 460 470 480
PGINSGMGTI PGVQSYRVDE KTKKYCIPFV KPNKHSPSGI YNMNVTTSVS SEKNLLQANK
490 500 510 520 530 540
KRGEYSKTDV RLPELNYNHL PELRALEGIA RNSRLIRKEN KILSESRIPS LAAIDLHTPN
550 560
IAVHQVSGSP LSDGSEADSP WMEHQH