Q9TT16

PR
Gene name
CLCN6
Protein name
H(+)/Cl(-) exchange transporter 6
Names
Chloride channel protein 6, ClC-6, Chloride transport protein 6
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100008750
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

651-742 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9TT16

Entry ID Method Resolution Chain Position Source
AF-Q9TT16-F1 Predicted AlphaFoldDB

No variants for Q9TT16

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TT16

No associated diseases with Q9TT16

2 regional properties for Q9TT16

Type Name Position InterPro Accession
domain CBS domain 601 - 657 IPR000644-1
domain CBS domain 806 - 868 IPR000644-2

Functions

Description
EC Number
Subcellular Localization
  • Late endosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.

3 GO annotations of molecular function

Name Definition
antiporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

1 GO annotations of biological process

Name Definition
chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP
70 80 90 100 110 120
YLEVLETMDH KKGRWYEVVK WTVVFAIGVC TGLVGLFVDF FVQLFTQLKF GVVEASVEEC
130 140 150 160 170 180
SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EIKCYLNGVK VPGIVRLRTL
190 200 210 220 230 240
LCKVFGVLFS VAGGLFVGKE GPMIHSGAVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD
250 260 270 280 290 300
FVSAGAAAGI AAAFGAPIGA TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF
310 320 330 340 350 360
GSWGSFQLPG LLNFGEFKCS DSDKKCHLWT AMDMGFFVVM GVIGGLLGAT FNCLNKRLAK
370 380 390 400 410 420
YRMRNVHPKP KLVRVLESLL VSLVTTLVVF VASMVLGECR QMSSSSQISN GSLKLQVTSD
430 440 450 460 470 480
VNSSIKAFFC PNDTYNDMAT LFFNPQESAI LQLFHQDGTF SPITLALFFV LYFLLACWTY
490 500 510 520 530 540
GISVPSGLFV PSLLCGAAFG RLVANVLKSY IGLSHIYSGT FSLIGAAALL GGVVRMTISL
550 560 570 580 590 600
TVILIESTNE ITYGLPIMIT LMVAKWTGDF FNKGIYDIHV GLRGVPLLEW ETEVEMDKLR
610 620 630 640 650 660
ASDIMEPNLT YVYPHTRIQS LVSILRTTVH HAFPVVTENR GNEKEFMKGN QLISNNIKFK
670 680 690 700 710 720
KSSILTRAGE QRRRSQSMKS YPSSELRNVC DEHVASEEPA EKEDLLQQML ERRYTPYPNL
730 740 750 760 770 780
YPDQSPSEDW TMEERFRPLT FHGLILRSQL VTLLVRGVCY SESQSSASQP RLSYAEMAED
790 800 810 820 830 840
YPRFPDIHDL DLTLLNPRMI VDVTPYMNPS PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA
850 860
VGEIVGIVTR HNLTYEFLQA RLRQHYQTI