Q9TEM3

PR
Gene name
mcsA
Protein name
2-methylcitrate synthase, mitochondrial
Names
Methylcitrate synthase, (2S,3S)-2-methylcitrate synthase, Citrate synthase 2
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN6650.2
EC number
2.3.3.5: Acyl groups converted into alkyl groups on transfer
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9TEM3

Entry ID Method Resolution Chain Position Source
AF-Q9TEM3-F1 Predicted AlphaFoldDB

No variants for Q9TEM3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TEM3

No associated diseases with Q9TEM3

6 regional properties for Q9TEM3

Type Name Position InterPro Accession
domain Translational (tr)-type GTP-binding domain 187 - 354 IPR000795
domain Small GTP-binding protein domain 191 - 346 IPR005225
domain Translation initiation factor IF-2, N-terminal 1 - 49 IPR006847-1
domain Translation initiation factor IF-2, N-terminal 110 - 158 IPR006847-2
domain Translation initiation factor IF- 2, domain 3 464 - 577 IPR023115
domain Translation initiation factor IF-2, domain II 362 - 457 IPR044145

Functions

Description
EC Number 2.3.3.5 Acyl groups converted into alkyl groups on transfer
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

2 GO annotations of molecular function

Name Definition
2-methylcitrate synthase activity Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+).
citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.

5 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
sterigmatocystin biosynthetic process The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALPLRTARH ASRLAQTIGR RGYATAEPDL KSALKAVIPA KRELLAEVKK QGDEVIGEVK
70 80 90 100 110 120
VSNVIGGMRG LKSMLWEGSV LDADEGIRFH GKTIKDCQKE LPKGPTGTEM LPEAMFWLLL
130 140 150 160 170 180
TGEVPSTSQV RAFSKQLAEE SHLPDHILDL AKSFPKHMHP MTQISIITAA LNTESKFAKL
190 200 210 220 230 240
YEKGINKADY WEPTFDDAIS LLAKIPRVAA LVFRPNEIDV VGRQKLDPAQ DWSYNFAELL
250 260 270 280 290 300
GKGGANNADF HDLLRLYLAL HGDHEGGNVS AHATHLVGSA LSDPFLSYSA GLLGLAGPLH
310 320 330 340 350 360
GLAAQEVLRW ILAMQEKIGT KFTDEDVRAY LWDTLKSGRV VPGYGHGVLR KPDPRFQALM
370 380 390 400 410 420
DFAATRKDVL ANPVFQLVKK NSEIAPGVLT EHGKTKNPHP NVDAASGVLF YHYGFQQPLY
430 440 450
YTVTFGVSRA LGPLVQLIWD RALGLPIERP KSINLLGLKK