Q9TA19

PR
Gene name
MT-ND5 (MTND5, NADH5, ND5)
Protein name
NADH-ubiquinone oxidoreductase chain 5
Names
NADH dehydrogenase subunit 5
Species
Loxodonta africana (African elephant)
KEGG Pathway
lav:808793
EC number
7.1.1.2: Hydron translocation or charge separation linked to oxidoreductase reactions
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

548-606 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9TA19

Entry ID Method Resolution Chain Position Source
AF-Q9TA19-F1 Predicted AlphaFoldDB

No variants for Q9TA19

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9TA19

No associated diseases with Q9TA19

3 regional properties for Q9TA19

Type Name Position InterPro Accession
domain NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal 71 - 121 IPR001516
domain NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit 137 - 418 IPR001750
domain NADH dehydrogenase subunit 5, C-terminal 425 - 604 IPR010934

Functions

Description
EC Number 7.1.1.2 Hydron translocation or charge separation linked to oxidoreductase reactions
Subcellular Localization
  • Mitochondrion inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

1 GO annotations of molecular function

Name Definition
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).

2 GO annotations of biological process

Name Definition
mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation.
mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVINLIPTL MLTSLIILTL PIITTLLQNN KTNCFLYITK TAVTYAFAIS LIPTLLFIQS
70 80 90 100 110 120
NQEAYISNWH WMTIHTLKLS MSFKLDFFSL TFMPIALFIT WSIMEFSLWY MHSDPHINRF
130 140 150 160 170 180
FKYLLLFLIT MLILVSANNL LQLFMGWEGV GIMSFLLISW WHGRTDANTA ALQAMLYNRI
190 200 210 220 230 240
GDMGFIMMMA WFTIHLNSWE FQQIFLTNPK NTTLPLLGLL LASAGKSAQF GLHPWLPSAM
250 260 270 280 290 300
EGPTPVSALL HSSTMVMAGV FTLIRFYPLM ENNLTIQTST LCLGAITTLF TAICALTQND
310 320 330 340 350 360
IKKIIALSTS SQLGLMMVTI GINQPQLAFI HMCTHAFFKA MLFLSSGSII HNLNNEQDIR
370 380 390 400 410 420
KMGGLYKTMP ITSTAIIIGS LALTGMPFLT GFYSKDPIIE TANMSYINTW ALLITLIAVS
430 440 450 460 470 480
MTASYSTRII FFALLGQPRY PPLTQVNENN PYLVNPIKRL ILGSIFMGFL ISMNTIPHTT
490 500 510 520 530 540
PQMTMPPHLK FMALAVTLLG FTVATELNNM THNLMFKQPS RMHTFSTMLG YYPTTTHRVL
550 560 570 580 590 600
PYPSLTMSQN LATTIMDSIW LEKMIPKNLT TMQKTAASLV SNQKGLMKLY FLSFLLSITL
GLLIAL