Q9SZA3

PR
Gene name
TIF3K1 (At4g33250, F17M5.10)
Protein name
Eukaryotic translation initiation factor 3 subunit K
Names
eIF3k, eIF-3 p25
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G33250
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SZA3

Entry ID Method Resolution Chain Position Source
AF-Q9SZA3-F1 Predicted AlphaFoldDB

11 variants for Q9SZA3

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_16040598_G_A 7 S>L No 1000Genomes
tmp_4_16040592_T_A 9 Q>L No 1000Genomes
tmp_4_16040536_C_G 28 E>Q No 1000Genomes
ENSVATH02953028 85 S>I No 1000Genomes
ENSVATH00550141 116 F>L No 1000Genomes
ENSVATH12366136 127 R>L No 1000Genomes
tmp_4_16039741_T_C 128 H>R No 1000Genomes
tmp_4_16039503_A_T 143 Y>N No 1000Genomes
ENSVATH00550140 172 D>G No 1000Genomes
ENSVATH06817217 186 V>I No 1000Genomes
ENSVATH06817216 190 G>C No 1000Genomes

No associated diseases with Q9SZA3

2 regional properties for Q9SZA3

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 42 - 200 IPR000717
domain CSN8/PSMD8/EIF3K 62 - 187 IPR033464

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA.
eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA.
eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ribosome binding Binding to a ribosome.
RNA binding Binding to an RNA molecule or a portion thereof.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q94HF1 TIF3K1 Eukaryotic translation initiation factor 3 subunit K Oryza sativa subsp japonica (Rice) PR
10 20 30 40 50 60
MGVEIQSPQE QSSYTVEQLV ALNPFNPEIL PDLENYVNVT SQTYSLEVNL CLLRLYQFEP
70 80 90 100 110 120
ERMNTHIVAR ILVKALMAMP TPDFSLCLFL IPERVQMEEQ FKSLIVLSHY LETGRFQQFW
130 140 150 160 170 180
DEAAKNRHIL EAVPGFEQAI QAYASHLLSL SYQKVPRSVL AEAVNMDGAS LDKFIEQQVT
190 200 210 220
NSGWIVEKEG GSIVLPQNEF NHPELKKNTG ENVPLEHIAR IFPILG