Q9SXY0
PR
Gene name |
FAS1 (NFB2, At1g65470, F5I14.2, T8F5.24) |
Protein name |
Chromatin assembly factor 1 subunit FAS1 |
Names |
CAF-1 subunit FAS1, CAF-1 p150 homolog, Protein FASCIATA 1 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G65470 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SXY0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SXY0-F1 | Predicted | AlphaFoldDB |
143 variants for Q9SXY0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05069429 | 2 | D>E | No | 1000Genomes | |
| ENSVATH14418733 | 6 | T>K | No | 1000Genomes | |
| tmp_1_24323860_A_C | 7 | V>G | No | 1000Genomes | |
| ENSVATH05069428 | 8 | N>K | No | 1000Genomes | |
| tmp_1_24323855_C_T | 9 | E>K | No | 1000Genomes | |
| ENSVATH05069427 | 10 | N>I | No | 1000Genomes | |
| ENSVATH01471388 | 13 | R>G | No | 1000Genomes | |
| ENSVATH05069426 | 13 | R>Q | No | 1000Genomes | |
| ENSVATH05069425 | 17 | I>M | No | 1000Genomes | |
| ENSVATH05069424 | 20 | K>N | No | 1000Genomes | |
| ENSVATH01471387 | 22 | L>P | No | 1000Genomes | |
| tmp_1_24323767_T_C | 38 | E>G | No | 1000Genomes | |
| ENSVATH13733244 | 53 | G>R | No | 1000Genomes | |
| tmp_1_24323714_C_G | 56 | D>H | No | 1000Genomes | |
| tmp_1_24323699_C_A | 61 | V>F | No | 1000Genomes | |
| ENSVATH05069420 | 64 | K>Q | No | 1000Genomes | |
| tmp_1_24323689_T_C | 64 | K>R | No | 1000Genomes | |
| ENSVATH00123848 | 83 | M>L | No | 1000Genomes | |
| ENSVATH05069419 | 85 | A>G | No | 1000Genomes | |
| tmp_1_24323589_C_G | 97 | K>N | No | 1000Genomes | |
| tmp_1_24323576_T_C | 102 | I>V | No | 1000Genomes | |
| tmp_1_24323572_T_G | 103 | Y>S | No | 1000Genomes | |
| ENSVATH01471384 | 105 | K>N | No | 1000Genomes | |
| ENSVATH01471383 | 110 | T>I | No | 1000Genomes | |
| ENSVATH14418731 | 114 | T>I | No | 1000Genomes | |
| ENSVATH00123846 | 115 | M>K | No | 1000Genomes | |
| tmp_1_24323537_T_C | 115 | M>V | No | 1000Genomes | |
| tmp_1_24323521_C_G | 120 | S>T | No | 1000Genomes | |
| ENSVATH05069418 | 122 | V>A | No | 1000Genomes | |
| ENSVATH13733240 | 129 | V>I | No | 1000Genomes | |
| ENSVATH13733239 | 145 | S>T | No | 1000Genomes | |
| ENSVATH13733238 | 146 | E>D | No | 1000Genomes | |
| tmp_1_24323280_G_C | 159 | I>M | No | 1000Genomes | |
| ENSVATH01471377 | 161 | P>Q | No | 1000Genomes | |
| tmp_1_24323269_G_A | 163 | S>F | No | 1000Genomes | |
| tmp_1_24323267_C_T | 164 | V>I | No | 1000Genomes | |
| ENSVATH13733235 | 167 | V>G | No | 1000Genomes | |
| tmp_1_24323258_C_T | 167 | V>M | No | 1000Genomes | |
| ENSVATH00123844 | 168 | L>I | No | 1000Genomes | |
| ENSVATH13733234 | 183 | T>I | No | 1000Genomes | |
| tmp_1_24323093_C_T | 195 | E>K | No | 1000Genomes | |
| ENSVATH05069412 | 196 | E>G | No | 1000Genomes | |
| ENSVATH05069411 | 197 | T>S | No | 1000Genomes | |
| ENSVATH01471372 | 200 | L>S | No | 1000Genomes | |
| ENSVATH05069410 | 209 | A>G | No | 1000Genomes | |
| ENSVATH05069409 | 210 | E>K | No | 1000Genomes | |
| tmp_1_24323044_T_C | 211 | K>R | No | 1000Genomes | |
| ENSVATH05069407 | 225 | M>L | No | 1000Genomes | |
| tmp_1_24322881_T_G | 238 | E>A | No | 1000Genomes | |
| ENSVATH05069401 | 244 | E>G | No | 1000Genomes | |
| tmp_1_24322829_A_C | 255 | N>K | No | 1000Genomes | |
| tmp_1_24322811_C_A | 261 | K>N | No | 1000Genomes | |
| ENSVATH01471365 | 266 | M>I | No | 1000Genomes | |
| ENSVATH05069400 | 267 | E>K | No | 1000Genomes | |
| tmp_1_24322777_C_T | 273 | E>K | No | 1000Genomes | |
| tmp_1_24322769_C_A | 275 | L>F | No | 1000Genomes | |
| tmp_1_24322607_T_G | 286 | K>Q | No | 1000Genomes | |
| tmp_1_24322604_C_T | 287 | A>T | No | 1000Genomes | |
| ENSVATH01471361 | 289 | V>I | No | 1000Genomes | |
| tmp_1_24322594_T_C | 290 | D>G | No | 1000Genomes | |
| ENSVATH01471360 | 296 | K>R | No | 1000Genomes | |
| ENSVATH01471359 | 302 | R>K | No | 1000Genomes | |
| ENSVATH05069396 | 307 | K>R | No | 1000Genomes | |
| tmp_1_24322525_T_G | 313 | E>A | No | 1000Genomes | |
| ENSVATH05069394 | 324 | A>V | No | 1000Genomes | |
| tmp_1_24322453_G_A | 337 | S>L | No | 1000Genomes | |
| ENSVATH05069393 | 351 | L>F | No | 1000Genomes | |
| tmp_1_24322405_T_A | 353 | Q>L | No | 1000Genomes | |
| ENSVATH01471357 | 354 | P>S | No | 1000Genomes | |
| tmp_1_24322390_G_A | 358 | S>F | No | 1000Genomes | |
| tmp_1_24322382_C_G | 361 | V>L | No | 1000Genomes | |
| ENSVATH05069392 | 370 | K>Q | No | 1000Genomes | |
| tmp_1_24322352_G_A | 371 | H>Y | No | 1000Genomes | |
| ENSVATH05069391 | 380 | Q>R | No | 1000Genomes | |
| tmp_1_24322312_T_C | 384 | N>S | No | 1000Genomes | |
| tmp_1_24322313_T_A | 384 | N>Y | No | 1000Genomes | |
| ENSVATH05069390 | 390 | C>Y | No | 1000Genomes | |
| ENSVATH05069387 | 415 | S>L | No | 1000Genomes | |
| tmp_1_24322108_G_C | 425 | P>R | No | 1000Genomes | |
| ENSVATH05069386 | 429 | L>M | No | 1000Genomes | |
| ENSVATH13733221 | 459 | N>D | No | 1000Genomes | |
| ENSVATH00123835 | 459 | N>K | No | 1000Genomes | |
| ENSVATH00123834 | 463 | G>D | No | 1000Genomes | |
| ENSVATH00123834 | 463 | G>V | No | 1000Genomes | |
| tmp_1_24321980_G_A | 468 | P>S | No | 1000Genomes | |
| ENSVATH01471354 | 470 | S>P | No | 1000Genomes | |
| ENSVATH01471353 | 473 | R>C | No | 1000Genomes | |
| ENSVATH00123833 | 474 | K>T | No | 1000Genomes | |
| ENSVATH14418728 | 476 | S>F | No | 1000Genomes | |
| ENSVATH00123832 | 479 | V>A | No | 1000Genomes | |
| ENSVATH00123832 | 479 | V>G | No | 1000Genomes | |
| tmp_1_24321936_C_A | 482 | L>F | No | 1000Genomes | |
| tmp_1_24321921_T_A | 487 | K>N | No | 1000Genomes | |
| tmp_1_24321896_T_C | 496 | I>V | No | 1000Genomes | |
| ENSVATH14418711 | 514 | P>A | No | 1000Genomes | |
| ENSVATH01471344 | 523 | D>E | No | 1000Genomes | |
| tmp_1_24321151_C_T | 545 | S>N | No | 1000Genomes | |
| ENSVATH05069372 | 551 | S>L | No | 1000Genomes | |
| ENSVATH00123818 | 586 | S>F | No | 1000Genomes | |
| ENSVATH13733184 | 587 | E>D | No | 1000Genomes | |
| tmp_1_24320758_T_C | 588 | Q>R | No | 1000Genomes | |
| ENSVATH00123817 | 590 | A>G | No | 1000Genomes | |
| ENSVATH01471338 | 591 | N>H | No | 1000Genomes | |
| ENSVATH01471338 | 591 | N>Y | No | 1000Genomes | |
| tmp_1_24320746_G_A | 592 | T>M | No | 1000Genomes | |
| ENSVATH01471337 | 593 | T>I | No | 1000Genomes | |
| ENSVATH00123816 | 593 | T>P | No | 1000Genomes | |
| tmp_1_24320707_C_G | 605 | C>S | No | 1000Genomes | |
| tmp_1_24320618_G_A | 635 | H>Y | No | 1000Genomes | |
| tmp_1_24320588_C_T | 645 | D>N | No | 1000Genomes | |
| tmp_1_24320585_G_C | 646 | L>V | No | 1000Genomes | |
| ENSVATH01471335 | 663 | R>Q | No | 1000Genomes | |
| ENSVATH01471334 | 664 | Q>P | No | 1000Genomes | |
| ENSVATH01471333 | 666 | P>A | No | 1000Genomes | |
| tmp_1_24320520_C_G | 667 | W>C | No | 1000Genomes | |
| tmp_1_24320519_A_C | 668 | S>A | No | 1000Genomes | |
| tmp_1_24320506_T_C | 672 | E>G | No | 1000Genomes | |
| tmp_1_24320500_G_A | 674 | S>L | No | 1000Genomes | |
| tmp_1_24320501_A_G | 674 | S>P | No | 1000Genomes | |
| ENSVATH00123811 | 678 | I>T | No | 1000Genomes | |
| tmp_1_24320483_C_T | 680 | D>N | No | 1000Genomes | |
| tmp_1_24320482_T_A | 680 | D>V | No | 1000Genomes | |
| ENSVATH01471331 | 685 | A>T | No | 1000Genomes | |
| tmp_1_24320464_C_T | 686 | S>N | No | 1000Genomes | |
| tmp_1_24320459_A_T | 688 | F>I | No | 1000Genomes | |
| ENSVATH01471329 | 688 | F>L | No | 1000Genomes | |
| ENSVATH01471330 | 688 | F>S | No | 1000Genomes | |
| ENSVATH01471328 | 703 | I>F | No | 1000Genomes | |
| ENSVATH01471327 | 703 | I>T | No | 1000Genomes | |
| ENSVATH01471328 | 703 | I>V | No | 1000Genomes | |
| tmp_1_24320407_G_T | 705 | P>Q | No | 1000Genomes | |
| tmp_1_24320408_G_T | 705 | P>T | No | 1000Genomes | |
| tmp_1_24320181_G_A | 756 | R>C | No | 1000Genomes | |
| ENSVATH05069361 | 772 | S>L | No | 1000Genomes | |
| tmp_1_24320032_A_T | 774 | D>E | No | 1000Genomes | |
| tmp_1_24320025_C_A | 777 | G>C | No | 1000Genomes | |
| ENSVATH01471312 | 797 | T>S | No | 1000Genomes | |
| ENSVATH01471310 | 799 | P>S | No | 1000Genomes | |
| tmp_1_24319953_G_C | 801 | P>A | No | 1000Genomes | |
| ENSVATH00123802 | 809 | R>I | No | 1000Genomes | |
| tmp_1_24319921_T_A | 811 | E>D | No | 1000Genomes | |
| ENSVATH00123801 | 812 | N>I | No | 1000Genomes | |
| ENSVATH00123801 | 812 | N>T | No | 1000Genomes |
No associated diseases with Q9SXY0
5 regional properties for Q9SXY0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 2 - 50 | IPR001680-1 |
| repeat | WD40 repeat | 53 - 101 | IPR001680-2 |
| repeat | WD40 repeat | 101 - 182 | IPR001680-3 |
| repeat | WD40 repeat | 329 - 369 | IPR001680-4 |
| conserved_site | WD40 repeat, conserved site | 127 - 141 | IPR019775 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| CAF-1 complex | A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
13 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| DNA recombination | Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. |
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| double-strand break repair via homologous recombination | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
| heterochromatin assembly | An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. |
| leaf development | The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. |
| multidimensional cell growth | The process in which a cell irreversibly increases in size in two or three |
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| pollen development | The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. |
| positive regulation of cell cycle | Any process that activates or increases the rate or extent of progression through the cell cycle. |
| regulation of meristem structural organization | Any process that modulates the frequency, rate or extent of meristem organization. |
| trichome differentiation | The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDEVSTVNEN | ENRKTMIEPK | KLNKRKREPT | AIENLTSEEK | ESQISSLNLE | MKGLFDYFRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VMDKSKRTDL | FSGFSECSSL | NSMVALLMEE | MSLPLSKLVD | EIYLKLKEKT | ESVTMVAVKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVVSVGQRVS | YGVLNVDADV | LEDDSESCLW | CWETRDLKIM | PSSVRGVLKL | RRTCRKKIHE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RITAVSAMLA | ALQREETEKL | WRSDLSKAAE | KLGKILSEVD | IRSFMDNMMQ | KNSSEMAEKD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKREEKLLLK | QLEKNRCEAE | KEKKRMERQV | LKEKLQQEKE | QKLLQKAIVD | ENNKEKEETE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRKRIKKQQD | ESEKEQKRRE | KEQAELKKQL | QVQKQASIME | RFLKKSKDSS | LTQPKLPSSE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VTAQELSCTK | HENEIGKVVQ | AIDNAFSTTC | EATVDDIRRE | HFASWRQLGH | LLSSSKKHWG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MRRQPKSELF | PKLKLSTNSG | VTSDGEPNME | KQGDGCEENN | FDGRQCKPSS | SNRKKSRRVK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QLLQFDKSCR | PGFYGIWPSQ | SQVVKPRRPL | QKDPELDYEV | DSDEEWEEEE | AGESLSDCEK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DEDESLEEGC | SKADDEDDSE | DDFMVPDGYL | SEDEGVQVDR | MDIDPSEQDA | NTTSSKQDQE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SPEFCALLQQ | QKHLQNLTDH | ALKKTQPLII | CNLTHEKVSL | LAAKDLEGTQ | KVEQICLRAL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| MVRQFPWSSL | IEISINDIQD | EDQEASKFSC | SQSTPPSNSK | AKIIPDSDLL | TVVSTIQSCS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QGINRVVETL | QQKFPDVPKT | KLRQKVREIS | DFEDSRWQVK | KEVLTKLGLS | PSPDKGGKRL |
| 790 | 800 | 810 | |||
| PKTISTFFSK | RCLPPSTKPQ | PAVEDAAERL | ENENA |