Q9SP06

PR
Gene name
CYP80B3
Protein name
(S)-N-methylcoclaurine 3'-hydroxylase isozyme 1
Names
Cytochrome P450 80B1, Cytochrome P450 80B3
Species
Papaver somniferum (Opium poppy)
KEGG Pathway
EC number
1.14.14.102: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

98-168 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SP06

Entry ID Method Resolution Chain Position Source
AF-Q9SP06-F1 Predicted AlphaFoldDB

No variants for Q9SP06

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9SP06

No associated diseases with Q9SP06

1 regional properties for Q9SP06

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 416 - 425 IPR017972

Functions

Description
EC Number 1.14.14.102 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Endoplasmic reticulum
  • Like CYP80B3b (AC I3V6B1), the full-length CYP80B3 is probably anchored to the membrane by a signal anchor (Probable)
  • Localized to the parietal region of the sieve element cytoplasm (PubMed:14508000)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

3 GO annotations of molecular function

Name Definition
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
N-methylcoclaurine 3'-monooxygenase activity Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+).

2 GO annotations of biological process

Name Definition
(S)-reticuline biosynthetic process The chemical reactions and pathways resulting in the formation of (S)-reticuline.
response to molecule of fungal origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
SLVAVVITTF LYLIFRDSSP KGLPPGPKPW PIVGNLLQLG EKPHSQFAQL AETYGDLFSL
70 80 90 100 110 120
KLGSETVVVA STPLAASEIL KTHDRVLSGR YVFQSFRVKE HVENSIVWSE CNETWKKLRK
130 140 150 160 170 180
VCRTELFTQK MIESQAEVRE SKAMEMVEYL KKNVGNEVKI AEVVFGTLVN IFGNLIFSQN
190 200 210 220 230 240
IFKLGDESSG SVEMKEHLWR MLELGNSTNP ADYFPFLGKF DLFGQSKDVA DCLQGIYSVW
250 260 270 280 290 300
GAMLKERKIA KQHNNSKKND FVEILLDSGL DDQQINALLM EIFGAGTETS ASTIEWALSE
310 320 330 340 350 360
LTKNPQVTAN MRLELLSVVG KRPVKESDIP NMPYLQAFVK ETLRLHPATP LLLPRRALET
370 380 390 400 410 420
CKVLNYTIPK ECQIMVNAWG IGRDPKRWTD PLKFSPERFL NSSIDFKGND FELIPFGAGR
430 440 450 460 470 480
RICPGVPLAT QFISLIVSSL VQNFDWGFPK GMDPSQLIME EKFGLTLQKE PPLYIVPKTR
D