Q9SFV7
Gene name |
GCH1 (GCHI) |
Protein name |
GTP cyclohydrolase 1 |
Names |
GTP cyclohydrolase I |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G07270 |
EC number |
3.5.4.16: In cyclic amidines |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SFV7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SFV7-F1 | Predicted | AlphaFoldDB |
25 variants for Q9SFV7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_2315515_T_G | 22 | I>S | No | 1000Genomes | |
| ENSVATH00310992 | 36 | Q>K | No | 1000Genomes | |
| ENSVATH10540622 | 67 | R>L | No | 1000Genomes | |
| ENSVATH05789778 | 81 | V>I | No | 1000Genomes | |
| tmp_3_2316137_G_A | 160 | R>H | No | 1000Genomes | |
| ENSVATH05789780 | 170 | Q>K | No | 1000Genomes | |
| ENSVATH02121105 | 194 | L>V | No | 1000Genomes | |
| tmp_3_2316265_C_T,A | 203 | R>C | No | 1000Genomes | |
| tmp_3_2316265_C_T,A | 203 | R>S | No | 1000Genomes | |
| tmp_3_2316286_G_A | 210 | V>I | No | 1000Genomes | |
| ENSVATH05789782 | 219 | D>Y | No | 1000Genomes | |
| tmp_3_2316317_A_G | 220 | E>G | No | 1000Genomes | |
| ENSVATH05789783 | 237 | V>I | No | 1000Genomes | |
| tmp_3_2316437_C_T | 260 | S>F | No | 1000Genomes | |
| tmp_3_2316446_C_T | 263 | S>L | No | 1000Genomes | |
| ENSVATH05789784 | 278 | L>V | No | 1000Genomes | |
| ENSVATH10540624 | 286 | L>W | No | 1000Genomes | |
| tmp_3_2316555_A_T | 299 | K>N | No | 1000Genomes | |
| tmp_3_2316580_A_C | 308 | N>H | No | 1000Genomes | |
| tmp_3_2316609_C_A | 317 | N>K | No | 1000Genomes | |
| tmp_3_2316649_C_A | 331 | H>N | No | 1000Genomes | |
| ENSVATH05789785 | 337 | P>L | No | 1000Genomes | |
| tmp_3_2316988_G_T | 444 | A>S | No | 1000Genomes | |
| tmp_3_2317007_A_C | 450 | D>A | No | 1000Genomes | |
| tmp_3_2317037_C_T | 460 | T>I | No | 1000Genomes |
No associated diseases with Q9SFV7
2 regional properties for Q9SFV7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GTP cyclohydrolase I domain | 35 - 187 | IPR020602-1 |
| domain | GTP cyclohydrolase I domain | 272 - 452 | IPR020602-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.4.16 | In cyclic amidines |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTP cyclohydrolase I activity | Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| 7,8-dihydroneopterin 3'-triphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate. |
| tetrahydrobiopterin biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. |
| tetrahydrofolate biosynthetic process | The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGALDEGCLN | LELDIGMKNG | CIELAFEHQP | ETLAIQDAVK | LLLQGLHEDV | NREGIKKTPF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVAKALREGT | RGYKQKVKDY | VQSALFPEAG | LDEGVGQAGG | VGGLVVVRDL | DHYSYCESCL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LPFHVKCHIG | YVPSGQRVLG | LSKFSRVTDV | FAKRLQDPQR | LADDICSALQ | HWVKPAGVAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLECSHIHFP | SLDLDSLNLS | SHRGFVKLLV | SSGSGVFEDE | SSNLWGEFQS | FLMFKGVKTQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ALCRNGSSVK | EWCPSVKSSS | KLSPEVDPEM | VSAVVSILKS | LGEDPLRKEL | IATPTRFLKW |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MLNFQRTNLE | MKLNSFNPAK | VNGEVKEKRL | HCELNMPFWS | MCEHHLLPFY | GVVHIGYFCA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EGSNPNPVGS | SLMKAIVHFY | GFKLQVQERM | TRQIAETLSP | LVGGDVIVVA | EAGHTCMISR |
| 430 | 440 | 450 | 460 | ||
| GIEKFGSSTA | TIAVLGRFSS | DNSARAMFLD | KIHTTNALKT | ESSSPF |