Q9SEZ6

PR
Gene name
At2g25100 (F13D4.60)
Protein name
Ribonuclease H2 subunit A
Names
RNase H2 subunit A, Ribonuclease HI large subunit, RNase HI large subunit, Ribonuclease HI subunit A
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G25100
EC number
3.1.26.4: Endoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

213-296 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SEZ6

Entry ID Method Resolution Chain Position Source
AF-Q9SEZ6-F1 Predicted AlphaFoldDB

16 variants for Q9SEZ6

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05585603 2 E>G No 1000Genomes
ENSVATH05585599 43 Q>E No 1000Genomes
ENSVATH01890361 64 E>D No 1000Genomes
ENSVATH13392812 67 E>K No 1000Genomes
tmp_2_10680789_A_G 82 I>T No 1000Genomes
tmp_2_10680635_G_A 104 H>Y No 1000Genomes
ENSVATH05585594 112 K>R No 1000Genomes
ENSVATH00246031 136 R>K No 1000Genomes
tmp_2_10680362_C_T 170 V>M No 1000Genomes
ENSVATH13392811 185 G>R No 1000Genomes
ENSVATH13392810 234 E>K No 1000Genomes
ENSVATH05585591 238 A>G No 1000Genomes
ENSVATH13392808 245 E>A No 1000Genomes
tmp_2_10679856_C_T 268 E>K No 1000Genomes
ENSVATH05585587 289 K>N No 1000Genomes
ENSVATH13392807 290 I>V No 1000Genomes

No associated diseases with Q9SEZ6

1 regional properties for Q9SEZ6

Type Name Position InterPro Accession
domain Ribonuclease HII/HIII domain 14 - 236 IPR024567

Functions

Description
EC Number 3.1.26.4 Endoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
ribonuclease H2 complex A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

2 GO annotations of biological process

Name Definition
DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O75792 RNASEH2A Ribonuclease H2 subunit A Homo sapiens (Human) PR
10 20 30 40 50 60
MESECLTPEW ASQPCLMGID EAGRGPVLGP MVYGCMYCPI SYQSSLASLH FADSKTLKEE
70 80 90 100 110 120
KREELYESLK LDKSLGWAVD VIDPRELSAK MLAKNKTNLN EISHNSAMGL IKRVLDMGVL
130 140 150 160 170 180
LTEAYLDTVG DPDKYRIKLS ERFPSIKFVV SKKADSLFPI VSGASIVAKV TRDRALKEWL
190 200 210 220 230 240
VEETGEDINR NFGSGYPGDP ETKAWLVQHK HSVFGFPSLV RFSWGTCTTH LKGEVEVAWE
250 260 270 280 290
ADENEESGNG SSSKRQAKLS SFGFKTCEKR SEEIESSGKG RCKFLQARKI QQLTQF