Q9SE26

PR
Gene name
ICL
Protein name
Isocitrate lyase
Names
ICL, Isocitrase, Isocitratsysase
Species
Dendrobium crumenatum (Tropical pigeon orchid)
KEGG Pathway
EC number
4.1.3.1: Oxo-acid-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-188 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SE26

Entry ID Method Resolution Chain Position Source
AF-Q9SE26-F1 Predicted AlphaFoldDB

No variants for Q9SE26

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9SE26

No associated diseases with Q9SE26

2 regional properties for Q9SE26

Type Name Position InterPro Accession
conserved_site Isocitrate lyase/phosphorylmutase, conserved site 210 - 215 IPR018523
domain ICL/PEPM domain 75 - 488 IPR039556

Functions

Description
EC Number 4.1.3.1 Oxo-acid-lyases
Subcellular Localization
  • Glyoxysome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.

2 GO annotations of molecular function

Name Definition
isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSSVPPMI TEEEARFEAE VSAVESWWRT DRFRLTRRPY SARDVVSLRG TLHHSYASDQ
70 80 90 100 110 120
MAKKLWRTLK SHQSAGTASR TFGALDPVQV TMMAKHLDTI YVSGWQCSST HTATNEPGPD
130 140 150 160 170 180
LADYPYNTVP NKVEHLFFAQ LYHDRKQHEA RVSMTREQRA KTPYVDYLRP IIADGDTGFG
190 200 210 220 230 240
GATATVKLCK LFVERGAAGV HIEDQSSVTK KCGHMAGKVL VAVSEHINRL VAARLQFDVM
250 260 270 280 290 300
GVETVLVART DAVAATLIQS NVDLRDHQFI LGATNPDFKR RSLAAVLSAA MAAGKTGAVL
310 320 330 340 350 360
QAIEDDWLSR AGLMTFSDAV INGINRQNLP EYEKQRRLNE WAAATEYSKC VSNEQGREIA
370 380 390 400 410 420
ERLGAGEIFW DWDIARTREG FYRFRGSVEA AVVRGRAFAP HADLIWMETS SPDLVECGKF
430 440 450 460 470 480
AQGMKASHPE IMLAYNLSPS FNWDAAGMTD EEMRDFIPRI AKMGFCWQFI TLGGFHADAL
490 500 510 520 530 540
VTDTFAREFA KQGMLAYVER IQREERNNGV DTLAHQKWSG ANYYDRYLKT VQGGISSTAA
550 560 570
MGKGVTEEQF KEESRTGTRG LDRGGITVNA KSRL