Q9SAI1
Gene name |
FDM5 |
Protein name |
Factor of DNA methylation 5 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G80790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SAI1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SAI1-F1 | Predicted | AlphaFoldDB |
62 variants for Q9SAI1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH05180889 | 14 | S>Y | No | 1000Genomes | |
| ENSVATH05180890 | 28 | M>K | No | 1000Genomes | |
| ENSVATH13846510 | 29 | N>K | No | 1000Genomes | |
| ENSVATH13846511 | 30 | G>W | No | 1000Genomes | |
| tmp_1_30360382_A_T | 35 | K>* | No | 1000Genomes | |
| tmp_1_30360487_G_A | 70 | A>T | No | 1000Genomes | |
| tmp_1_30360520_T_G | 81 | F>V | No | 1000Genomes | |
| ENSVATH05180893 | 85 | K>E | No | 1000Genomes | |
| ENSVATH05180895 | 89 | N>S | No | 1000Genomes | |
| ENSVATH14497304 | 90 | E>K | No | 1000Genomes | |
| ENSVATH05180896 | 99 | R>H | No | 1000Genomes | |
| tmp_1_30360592_T_G | 105 | S>A | No | 1000Genomes | |
| ENSVATH13846513 | 108 | E>D | No | 1000Genomes | |
| tmp_1_30360638_G_A | 120 | W>* | No | 1000Genomes | |
| ENSVATH01563701 | 148 | K>E | No | 1000Genomes | |
| tmp_1_30360748_G_A | 157 | V>M | No | 1000Genomes | |
| tmp_1_30360755_C_T | 159 | T>I | No | 1000Genomes | |
| tmp_1_30360851_A_T | 191 | Y>F | No | 1000Genomes | |
| ENSVATH05180899 | 200 | D>A | No | 1000Genomes | |
| ENSVATH05180900 | 200 | D>E | No | 1000Genomes | |
| tmp_1_30360899_A_C | 207 | D>A | No | 1000Genomes | |
| tmp_1_30360932_G_A | 218 | R>H | No | 1000Genomes | |
| ENSVATH13846514 | 251 | N>D | No | 1000Genomes | |
| ENSVATH13846514 | 251 | N>Y | No | 1000Genomes | |
| ENSVATH05180903 | 253 | S>N | No | 1000Genomes | |
| ENSVATH00800501 | 254 | I>S | No | 1000Genomes | |
| ENSVATH05180904 | 254 | I>V | No | 1000Genomes | |
| tmp_1_30361087_C_A | 270 | L>M | No | 1000Genomes | |
| ENSVATH05180905 | 271 | N>I | No | 1000Genomes | |
| tmp_1_30361103_A_G | 275 | Y>C | No | 1000Genomes | |
| ENSVATH05180906 | 289 | I>T | No | 1000Genomes | |
| ENSVATH05180907 | 296 | R>Q | No | 1000Genomes | |
| ENSVATH05180908 | 297 | V>I | No | 1000Genomes | |
| tmp_1_30361268_A_G | 302 | T>A | No | 1000Genomes | |
| ENSVATH05180912 | 302 | T>K | No | 1000Genomes | |
| ENSVATH13846515 | 310 | R>Q | No | 1000Genomes | |
| ENSVATH05180913 | 311 | E>A | No | 1000Genomes | |
| tmp_1_30361330_G_C | 322 | R>S | No | 1000Genomes | |
| tmp_1_30361358_A_G | 332 | N>D | No | 1000Genomes | |
| tmp_1_30361370_A_T | 336 | I>F | No | 1000Genomes | |
| tmp_1_30361377_C_T | 338 | S>F | No | 1000Genomes | |
| ENSVATH05180914 | 346 | A>V | No | 1000Genomes | |
| tmp_1_30361766_A_C | 394 | K>N | No | 1000Genomes | |
| tmp_1_30361791_C_G | 403 | Q>E | No | 1000Genomes | |
| tmp_1_30361793_G_T | 403 | Q>H | No | 1000Genomes | |
| tmp_1_30361910_G_A | 442 | M>I | No | 1000Genomes | |
| ENSVATH05180927 | 460 | E>Q | No | 1000Genomes | |
| ENSVATH14497309 | 466 | L>F | No | 1000Genomes | |
| tmp_1_30361995_C_T | 471 | R>C | No | 1000Genomes | |
| ENSVATH05180929 | 483 | F>C | No | 1000Genomes | |
| ENSVATH01563706 | 484 | L>F | No | 1000Genomes | |
| tmp_1_30362041_C_T | 486 | T>M | No | 1000Genomes | |
| tmp_1_30362040_A_C | 486 | T>P | No | 1000Genomes | |
| tmp_1_30362316_A_G | 487 | E>G | No | 1000Genomes | |
| ENSVATH05180941 | 519 | C>F | No | 1000Genomes | |
| ENSVATH05180942 | 520 | T>R | No | 1000Genomes | |
| tmp_1_30362686_G_A | 579 | V>M | No | 1000Genomes | |
| tmp_1_30362727_G_C | 592 | E>D | No | 1000Genomes | |
| ENSVATH14497312 | 602 | P>R | No | 1000Genomes | |
| ENSVATH05180946 | 619 | I>S | No | 1000Genomes | |
| tmp_1_30362819_C_T | 623 | T>M | No | 1000Genomes | |
| ENSVATH05180948 | 631 | R>L | No | 1000Genomes |
No associated diseases with Q9SAI1
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| gene silencing by RNA-directed DNA methylation | A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNSSDEESE | ISESEIDVYY | EKPYEKLMNG | DYKVKVKDTF | RCPFCAGKKK | QHYKYKELLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HASGVAKGSA | SRSAKQKANH | FALAKYMENE | LAGDADVPRP | QIPSSSTEQS | QAVVDDIYVW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PWMGIVINPV | RRTDNKNVLL | DSAYWLKKLA | RFNPLEVKTL | WLDQESVVAV | IPQFNSGWSG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FKSVTELEKE | YEIRGCGRKD | WIDKRGDWRS | KAYGWCARAD | DYNSQGSIAE | YLSKVGKLRS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FSDITKEEIQ | NKSIVVDDLA | NKIAMTNEDL | NKLQYMNNEK | TLSLRRVLIE | KDELDRVYKQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ETKKMQELSR | EKINRIFREK | ERLTNELEAK | MNNLKIWSKQ | LDKKQALTEL | ERQKLDEDKK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KSDVMNSSLQ | LASLEQKKTD | DRVLRLVDEH | KRKKEETLNK | ILQLEKELDS | KQKLQMEIQE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKGKLKVMKH | EDEDDEGIKK | KMKKMKEELE | EKCSELQDLE | DTNSALMVKE | RKSNDEIVEA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RKFLITELRE | LVSDRNIIRV | KRMGELEEKP | FMTACRQRCT | VEEEAQVQYA | MLCSKWQEKV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KDSAWQPFKH | VGTGDRKKEV | VDEEDEEIKK | LREEWGEEVK | NAVKTALEEL | NEFNPSGRYS |
| 610 | 620 | 630 | |||
| VPELWNSKQG | RKATLKEVID | YITQQVKTLK | RRRA |