Q9S7U9

PR
Gene name
MKK2 (MAP2K, MK1, At4g29810, F27B13.50)
Protein name
Mitogen-activated protein kinase kinase 2
Names
AtMAP2Kbeta, AtMKK2, MAP kinase kinase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G29810
EC number
2.7.12.2: Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-94 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

209-232 (Activation loop from InterPro)

Target domain

70-330 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q9S7U9

Entry ID Method Resolution Chain Position Source
AF-Q9S7U9-F1 Predicted AlphaFoldDB

10 variants for Q9S7U9

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH06799661 61 A>T No 1000Genomes
tmp_4_14594311_G_A 140 A>V No 1000Genomes
tmp_4_14594087_G_A 187 H>Y No 1000Genomes
ENSVATH02941779 243 K>N No 1000Genomes
ENSVATH06799650 243 K>R No 1000Genomes
tmp_4_14593784_C_T 257 V>I No 1000Genomes
tmp_4_14593631_A_T 308 S>T No 1000Genomes
ENSVATH02941778 314 D>E No 1000Genomes
tmp_4_14593505_T_C 322 K>E No 1000Genomes
tmp_4_14593504_T_C 322 K>R No 1000Genomes

No associated diseases with Q9S7U9

15 regional properties for Q9S7U9

Type Name Position InterPro Accession
domain Protein kinase domain 460 - 739 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 460 - 734 IPR001245
domain Immunoglobulin subtype 2 46 - 108 IPR003598-1
domain Immunoglobulin subtype 2 160 - 228 IPR003598-2
domain Immunoglobulin subtype 2 259 - 339 IPR003598-3
domain Immunoglobulin subtype 40 - 118 IPR003599-1
domain Immunoglobulin subtype 154 - 239 IPR003599-2
domain Immunoglobulin subtype 253 - 350 IPR003599-3
domain Immunoglobulin-like domain 16 - 122 IPR007110-1
domain Immunoglobulin-like domain 144 - 237 IPR007110-2
domain Immunoglobulin-like domain 246 - 348 IPR007110-3
domain Immunoglobulin I-set 37 - 102 IPR013098-1
domain Immunoglobulin I-set 159 - 238 IPR013098-2
domain Immunoglobulin I-set 253 - 349 IPR013098-3
binding_site Protein kinase, ATP binding site 466 - 496 IPR017441

Functions

Description
EC Number 2.7.12.2 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

8 GO annotations of biological process

Name Definition
auxin transport The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Auxins are a group of plant hormones that regulates aspects of plant growth.
cold acclimation Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.
defense response to other organism Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
pollen-pistil interaction The interaction between a pollen grain and pistil.
response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
xylem and phloem pattern formation The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q90891 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Gallus gallus (Chicken) PR
Q9XT09 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Pan troglodytes (Chimpanzee) PR
Q1HG70 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Canis lupus familiaris (Dog) (Canis familiaris) PR
Q24324 Dsor1 Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster (Fruit fly) PR
Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens (Human) EV
Q13163 MAP2K5 Dual specificity mitogen-activated protein kinase kinase 5 Homo sapiens (Human) PR
P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens (Human) EV
Q9WVS7 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Mus musculus (Mouse) PR
P31938 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Mus musculus (Mouse) PR
Q63932 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Mus musculus (Mouse) PR
Q01986 Map2k1 Dual specificity mitogen-activated protein kinase kinase 1 Rattus norvegicus (Rat) PR
Q62862 Map2k5 Dual specificity mitogen-activated protein kinase kinase 5 Rattus norvegicus (Rat) PR
P36506 Map2k2 Dual specificity mitogen-activated protein kinase kinase 2 Rattus norvegicus (Rat) SS
Q5QN75 MKK1 Mitogen-activated protein kinase kinase 1 Oryza sativa subsp japonica (Rice) PR
Q10664 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans PR
Q9FJV0 MKK6 Mitogen-activated protein kinase kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q94A06 MKK1 Mitogen-activated protein kinase kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MKKGGFSNNL KLAIPVAGEQ SITKFLTQSG TFKDGDLRVN KDGVRIISQL EPEVLSPIKP
70 80 90 100 110 120
ADDQLSLSDL DMVKVIGKGS SGVVQLVQHK WTGQFFALKV IQLNIDEAIR KAIAQELKIN
130 140 150 160 170 180
QSSQCPNLVT SYQSFYDNGA ISLILEYMDG GSLADFLKSV KAIPDSYLSA IFRQVLQGLI
190 200 210 220 230 240
YLHHDRHIIH RDLKPSNLLI NHRGEVKITD FGVSTVMTNT AGLANTFVGT YNYMSPERIV
250 260 270 280 290 300
GNKYGNKSDI WSLGLVVLEC ATGKFPYAPP NQEETWTSVF ELMEAIVDQP PPALPSGNFS
310 320 330 340 350 360
PELSSFISTC LQKDPNSRSS AKELMEHPFL NKYDYSGINL ASYFTDAGSP LATLGNLSGT
FSV