Q9S7P5
PR
Gene name |
SPL12 (At3g60030, T2O9.10) |
Protein name |
Squamosa promoter-binding-like protein 12 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G60030 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q9S7P5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1WJ0 | NMR | - | A | 124-181 | PDB |
| AF-Q9S7P5-F1 | Predicted | AlphaFoldDB |
71 variants for Q9S7P5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_22169395_C_G | 6 | E>Q | No | 1000Genomes | |
| tmp_3_22169345_C_G | 22 | R>S | No | 1000Genomes | |
| tmp_3_22169302_G_A | 37 | L>F | No | 1000Genomes | |
| tmp_3_22169301_A_T | 37 | L>H | No | 1000Genomes | |
| tmp_3_22169159_C_G | 84 | M>I | No | 1000Genomes | |
| tmp_3_22169139_T_A | 91 | D>V | No | 1000Genomes | |
| ENSVATH02528180 | 94 | A>G | No | 1000Genomes | |
| ENSVATH02528181 | 94 | A>S | No | 1000Genomes | |
| tmp_3_22169091_T_C | 107 | E>G | No | 1000Genomes | |
| ENSVATH06346478 | 112 | K>Q | No | 1000Genomes | |
| tmp_3_22169049_G_A | 121 | P>L | No | 1000Genomes | |
| tmp_3_22169036_A_C | 125 | I>M | No | 1000Genomes | |
| tmp_3_22169020_T_A | 131 | N>Y | No | 1000Genomes | |
| tmp_3_22168996_C_A | 139 | V>F | No | 1000Genomes | |
| ENSVATH14458150 | 165 | Q>R | No | 1000Genomes | |
| tmp_3_22168791_C_T | 178 | E>K | No | 1000Genomes | |
| ENSVATH02528178 | 217 | T>K | No | 1000Genomes | |
| ENSVATH14458149 | 230 | S>A | No | 1000Genomes | |
| tmp_3_22168509_G_A | 237 | S>L | No | 1000Genomes | |
| tmp_3_22168497_C_T | 241 | G>D | No | 1000Genomes | |
| ENSVATH14458148 | 253 | L>F | No | 1000Genomes | |
| tmp_3_22168446_C_T | 258 | G>D | No | 1000Genomes | |
| ENSVATH06346469 | 293 | A>S | No | 1000Genomes | |
| tmp_3_22168278_T_C | 314 | N>S | No | 1000Genomes | |
| ENSVATH06346468 | 324 | R>K | No | 1000Genomes | |
| ENSVATH02528175 | 329 | V>G | No | 1000Genomes | |
| tmp_3_22168116_T_C | 368 | Q>R | No | 1000Genomes | |
| ENSVATH00428719 | 371 | R>H | No | 1000Genomes | |
| tmp_3_22168089_T_C | 377 | Q>R | No | 1000Genomes | |
| tmp_3_22167923_G_A | 404 | R>W | No | 1000Genomes | |
| tmp_3_22167865_C_T | 423 | G>E | No | 1000Genomes | |
| ENSVATH12842712 | 430 | A>T | No | 1000Genomes | |
| tmp_3_22167583_G_T | 461 | L>I | No | 1000Genomes | |
| tmp_3_22167567_C_G | 466 | S>T | No | 1000Genomes | |
| tmp_3_22167372_A_T | 504 | L>H | No | 1000Genomes | |
| ENSVATH06346464 | 511 | R>S | No | 1000Genomes | |
| ENSVATH06346463 | 521 | V>I | No | 1000Genomes | |
| ENSVATH00428716 | 554 | H>Y | No | 1000Genomes | |
| ENSVATH14458145 | 569 | D>A | No | 1000Genomes | |
| tmp_3_22167057_C_T | 585 | M>I | No | 1000Genomes | |
| ENSVATH06346455 | 611 | V>I | No | 1000Genomes | |
| ENSVATH12842707 | 615 | E>K | No | 1000Genomes | |
| tmp_3_22166876_A_G | 617 | I>T | No | 1000Genomes | |
| ENSVATH08161864 | 656 | K>N | No | 1000Genomes | |
| ENSVATH08161863 | 657 | S>L | No | 1000Genomes | |
| ENSVATH00428715 | 660 | A>V | No | 1000Genomes | |
| ENSVATH06346454 | 661 | A>G | No | 1000Genomes | |
| tmp_3_22166711_A_G | 672 | L>S | No | 1000Genomes | |
| tmp_3_22166698_C_G | 676 | K>N | No | 1000Genomes | |
| tmp_3_22166673_G_A | 685 | R>W | No | 1000Genomes | |
| tmp_3_22166640_T_A | 696 | N>Y | No | 1000Genomes | |
| tmp_3_22166580_A_C | 716 | C>G | No | 1000Genomes | |
| tmp_3_22166546_T_C | 727 | K>R | No | 1000Genomes | |
| tmp_3_22166544_G_T | 728 | P>T | No | 1000Genomes | |
| ENSVATH02528170 | 735 | R>K | No | 1000Genomes | |
| tmp_3_22166513_G_A | 738 | P>L | No | 1000Genomes | |
| tmp_3_22166471_T_A | 752 | D>V | No | 1000Genomes | |
| tmp_3_22166454_C_T | 758 | G>S | No | 1000Genomes | |
| ENSVATH06346452 | 772 | E>G | No | 1000Genomes | |
| tmp_3_22166376_T_G | 784 | M>L | No | 1000Genomes | |
| ENSVATH00428713 | 792 | N>I | No | 1000Genomes | |
| tmp_3_22166157_T_C | 828 | K>R | No | 1000Genomes | |
| ENSVATH02528168 | 842 | E>Q | No | 1000Genomes | |
| tmp_3_22166113_G_T | 843 | H>N | No | 1000Genomes | |
| tmp_3_22166104_C_T | 846 | E>K | No | 1000Genomes | |
| ENSVATH02528167 | 871 | R>L | No | 1000Genomes | |
| ENSVATH02528166 | 886 | A>T | No | 1000Genomes | |
| ENSVATH12842706 | 893 | I>V | No | 1000Genomes | |
| tmp_3_22165959_G_C | 894 | A>G | No | 1000Genomes | |
| tmp_3_22165938_G_T | 901 | A>D | No | 1000Genomes | |
| ENSVATH00428711 | 927 | S>R | No | 1000Genomes |
No associated diseases with Q9S7P5
1 regional properties for Q9S7P5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SBP domain | 124 - 201 | IPR004333 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SMX9 | SPL1 | Squamosa promoter-binding-like protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEARIEGEVE | GHSLEYGFSG | KRSVEWDLND | WKWNGDLFVA | TQLNHGSSNS | SSTCSDEGNV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIMERRRIEM | EKKKKRRAVT | VVAMEEDNLK | DDDAHRLTLN | LGGNNIEGNG | VKKTKLGGGI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSRAICCQVD | NCGADLSKVK | DYHRRHKVCE | IHSKATTALV | GGIMQRFCQQ | CSRFHVLEEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DEGKRSCRRR | LAGHNKRRRK | ANPDTIGNGT | SMSDDQTSNY | MLITLLKILS | NIHSNQSDQT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GDQDLLSHLL | KSLVSQAGEH | IGRNLVGLLQ | GGGGLQASQN | IGNLSALLSL | EQAPREDIKH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HSVSETPWQE | VYANSAQERV | APDRSEKQVK | VNDFDLNDIY | IDSDDTTDIE | RSSPPPTNPA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TSSLDYHQDS | RQSSPPQTSR | RNSDSASDQS | PSSSSGDAQS | RTDRIVFKLF | GKEPNDFPVA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LRGQILNWLA | HTPTDMESYI | RPGCIVLTIY | LRQDEASWEE | LCCDLSFSLR | RLLDLSDDPL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WTDGWLYLRV | QNQLAFAFNG | QVVLDTSLPL | RSHDYSQIIT | VRPLAVTKKA | QFTVKGINLR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RPGTRLLCTV | EGTHLVQEAT | QGGMEERDDL | KENNEIDFVN | FSCEMPIASG | RGFMEIEDQG |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GLSSSFFPFI | VSEDEDICSE | IRRLESTLEF | TGTDSAMQAM | DFIHEIGWLL | HRSELKSRLA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ASDHNPEDLF | SLIRFKFLIE | FSMDREWCCV | MKKLLNILFE | EGTVDPSPDA | ALSELCLLHR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AVRKNSKPMV | EMLLRFSPKK | KNQTLAGLFR | PDAAGPGGLT | PLHIAAGKDG | SEDVLDALTE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPGMTGIQAW | KNSRDNTGFT | PEDYARLRGH | FSYIHLVQRK | LSRKPIAKEH | VVVNIPESFN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IEHKQEKRSP | MDSSSLEITQ | INQCKLCDHK | RVFVTTHHKS | VAYRPAMLSM | VAIAAVCVCV |
| 910 | 920 | ||||
| ALLFKSCPEV | LYVFQPFRWE | LLEYGTS |