Q9S158

PR
Gene name
mhpA
Protein name
3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase
Names
3-HCI hydroxylase, 3-HPP hydroxylase
Species
Comamonas testosteroni (Pseudomonas testosteroni)
KEGG Pathway
EC number
1.14.13.127: With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

416-490 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9S158

Entry ID Method Resolution Chain Position Source
AF-Q9S158-F1 Predicted AlphaFoldDB

No variants for Q9S158

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9S158

No associated diseases with Q9S158

6 regional properties for Q9S158

Type Name Position InterPro Accession
domain Helicase, C-terminal 809 - 970 IPR001650
domain CarD-like/TRCF, RNAP-interacting domain 495 - 592 IPR003711
domain Transcription-repair-coupling factor, C-terminal domain 1021 - 1121 IPR005118
domain DEAD/DEAH box helicase domain 621 - 780 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 616 - 806 IPR014001
domain UvrB, interaction domain 140 - 227 IPR041471

Functions

Description
EC Number 1.14.13.127 With NADH or NADPH as one donor, and incorporation of one atom of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
3-(3-hydroxyphenyl)propionate hydroxylase activity Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

2 GO annotations of biological process

Name Definition
3-(3-hydroxy)phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate.
3-phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNAPQENQAS QDDADVLIIG AGPVGLTLAN TLGMAGVRVI VAEKLPRIID YPRAIGIDDE
70 80 90 100 110 120
SLRTLQAAGL SDQVQAHITP HHWMRFYTAS GQCFASIEPR TDEYGWSRRN AFIQPQVDDI
130 140 150 160 170 180
LYRGLQRFDQ VQVLLGHELH SFSQDDAGIT ATLKDADGVE RTLRAKYLVA SDGGNSLVRR
190 200 210 220 230 240
MLNVAFEGRT KPNQWIVVDV RNDPLGTPHI DMHCDPQRPY VSAALPHGIR RFEFMVMPGE
250 260 270 280 290 300
TEEQLSRPEN LAQLMRKVVA DPDKVDYIRK RVYTHNARLA AQFRVDRILL AGDAAHIMPV
310 320 330 340 350 360
WQGQGYNSGM RDASNLAWKL AMVVKGEARS DLLDSYEQER RDHARSMIHL SEVAGDIFAP
370 380 390 400 410 420
ESHTAAKVRD TVMLALNAVP PVKQYFAEMR FKPMPRYEQG VVLHHTGTGN QGVRTPFAGL
430 440 450 460 470 480
LDRSGNTPLG RLLGLMAEKK ESLVGRLVHG LETAASSPVG RMFIQPRVAT ANGHSGLLDD
490 500 510 520 530 540
FVGLNFCILA WGTDPSYGMD EEALNFWQRL GARFIRAMPA GQLLHPTPTR DGVLTVGDEQ
550 560 570 580
GRLKDWFSAQ GKSVVFVRPD RFVAALASPQ EVSAVTRQMA RVLHSPLEA