Q9RUP8

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG Pathway
dra:DR_1335
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

827-904 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9RUP8

Entry ID Method Resolution Chain Position Source
AF-Q9RUP8-F1 Predicted AlphaFoldDB

No variants for Q9RUP8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9RUP8

No associated diseases with Q9RUP8

3 regional properties for Q9RUP8

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class Ia 22 - 673 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 723 - 866 IPR013155
domain Isoleucyl tRNA synthetase type 2, anticodon-binding domain 676 - 852 IPR033709

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKRTFAPVP TQPNFRQLEA DILQKWKDEQ VFEQTQTRPA PAGEFVFYEG PPTANGKPAL
70 80 90 100 110 120
HHVLARSFKD LFPRFKVMQG HHVTRKGGWD THGLPVEISV EKKLGWLGRN HGASREELEE
130 140 150 160 170 180
FNRLCRTSVW ETIQDWNELT ERMGYWLDLG DPYITYQNSY VESVWNLLRR LHEKGLVAQD
190 200 210 220 230 240
YKVVPLSPRI SSTLSRAELG EVDSYRMVDD PSVYVRLPIV WDTLPERAHA ALSSLSGEQR
250 260 270 280 290 300
QGLSLLVWTT TPWTLPSNTL AAVNPDLDYV VADSPSGRVI VAEGAVERLS ALHKDAAPLE
310 320 330 340 350 360
VLARFKGRDL EWVEYEPPFP EVASQLGVVS ELHERRDGKP VLHFVVMADF VSDVDGSGVA
370 380 390 400 410 420
HEAPAYGAED LEVARAYGVP LMFGVDDHGI LQVTHEQGKF FKDADKGLIA DMKARGLMFW
430 440 450 460 470 480
AGTLKHRYPF HDRTGDPILY FAKKGWYIRT SQVAGEMLAQ NEKINWVPGN IKHGRFGNWL
490 500 510 520 530 540
EGNVDWAISR ERYWGTPLPF WQSESGQLRV IGSVAELSEL AGRDLSDLDL HRPYIDDITF
550 560 570 580 590 600
TLDGEEYRRV PEVLDVWFDS GSMPYAQWGL LLNEQGEAVR GAEQFAKHYP ADYICEAIDQ
610 620 630 640 650 660
TRGWFYSLHA ISTMLYDQPA YKNVICLGHI VDEKGLKMSK SKGNVVAPLP LFDQYGADSV
670 680 690 700 710 720
RWYMFMASDP GDQKRFSERL VAEAQRSYVN TLWNVYSFFV LYANLDQPDL AAAPAVAERP
730 740 750 760 770 780
EMDRWLLARL EETVRDVTAA LESYDARSGG RALEGFVDDL SNWYVRRSRS RFWGEGGTVD
790 800 810 820 830 840
TAAYATLHEA LLVVSQLTAP FTPFLADALY RNLSGEESSV HLTPWPTVRA ERLDRKLTAD
850 860 870 880 890 900
MAAVMKVVEL GRAVRGAHNL KTRQPLAGVQ VRAASPEALD ALKRSQTQIM EELNVKAVTF
910 920 930 940 950 960
LEGDTDLVQY SLRPNLPVVG KQYGKQLPVL KKALTEADAR AVATAVQAGQ GFSVQADGVT
970 980 990 1000 1010 1020
FDLTPGSVLV DAKAPEGVAA AEDAGYLVAF DTALTPELVR EGLARDLVRA IQEARKAAGF
1030 1040 1050 1060 1070
EVQDRIALAL ELDGEALEAA QAWQDFIAGE VLAEQVAYGS GEGFRAEVEG GAVTLKKL