Q9RSP3

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG Pathway
dra:DR_2081
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9RSP3

Entry ID Method Resolution Chain Position Source
AF-Q9RSP3-F1 Predicted AlphaFoldDB

No variants for Q9RSP3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9RSP3

No associated diseases with Q9RSP3

7 regional properties for Q9RSP3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 330 - 539 IPR002314
domain TGS 1 - 60 IPR004095
domain Anticodon-binding 551 - 643 IPR004154
domain Aminoacyl-tRNA synthetase, class II 279 - 544 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 174 - 224 IPR012947
domain Threonine-tRNA ligase catalytic core domain 248 - 549 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 549 - 642 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHVTLPDGKQ LDLQPGATAL DAAKAIGPRL AQDALGATAN GELTDLMTPL SDGASITLIT
70 80 90 100 110 120
KKNPGDAAPL FRHSLGHVMS QAVGEYYKAK GYGPDAIKRG VGPYIENGWY QDFDLPEPLK
130 140 150 160 170 180
EEDLPEIEKI MRDIIGRGLD ITRREISKDE ALAQFPHDPY KAELIEGLPD DEPITFYSQG
190 200 210 220 230 240
DYTDLCRGPH FPSTGKLPQS FKLMSTSGAY WRGNEKNPIL QRIYGVAFAT QKELDEYLFQ
250 260 270 280 290 300
LEEAKRRDHR KLGKELELFT IDPLVGKGLP LWLPNGTVLR EELTNFMKEQ QFQRGYQGVV
310 320 330 340 350 360
TPNIGNLDLY RTSGHYPYYS ESQFNPIQVD EEEYMLKPMN CPHHVRIYAS KPRSYRDLPV
370 380 390 400 410 420
RLAEFGTVYR YEQSGELNGL TRVRGFTQDD AHIFCRPDQL KREFLDVLDL TVLVLKTFGM
430 440 450 460 470 480
TDVRFRVGVR DPESDKYVGD EQNWALAERQ IIEAVEEVGL PYTIEPGDAA FYGPKLDFVV
490 500 510 520 530 540
KDVLGREWQL GTIQVDYNLP ERFDISYTGE DGQEHRPIMI HRAPFGSIER FTGILIEHYA
550 560 570 580 590 600
GDFPLWLAPR QVMIIPIADR HNAYAEELRE ELHRAGLRAE VDDSSNRMQA KVRDAELHKI
610 620 630 640
PVMLIVGDKE QEAREVSVRE RTGEGTKERK GVKFDELKAE LLERRKNRS