Q9RSE6

PR
Gene name
purB (DR_2178)
Protein name
Adenylosuccinate lyase
Names
ASL, Adenylosuccinase, ASase
Species
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG Pathway
dra:DR_2178
EC number
4.3.2.2: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

231-300 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9RSE6

Entry ID Method Resolution Chain Position Source
AF-Q9RSE6-F1 Predicted AlphaFoldDB

No variants for Q9RSE6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9RSE6

No associated diseases with Q9RSE6

3 regional properties for Q9RSE6

Type Name Position InterPro Accession
domain Adenylosuccinate lyase C-terminal 355 - 434 IPR019468
conserved_site Fumarate lyase, conserved site 267 - 276 IPR020557
domain Fumarate lyase, N-terminal 8 - 288 IPR022761

Functions

Description
EC Number 4.3.2.2 Lyases acting on amides, amidines, etc
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.

2 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDRYLTPEM KVLWSEANKY RAWLKVELSA LQAQARHGEV PAEAHAALVQ KSEADPLDDA
70 80 90 100 110 120
FAQQVAEIEA VTRHDIVAFT RALTERYGEE ARFIHHGLTS TDVVDTAQNL LLDEAMGLII
130 140 150 160 170 180
TDVQTLREVC RMQAAAHKHT PVVGRTHGIH AEPMTFGLKF LNWMATLDRD LERLQAARGR
190 200 210 220 230 240
VQVVMLSGSV GTYAHVSPKI EEEVAESWGW HAAPVTNQTL ARDRHAEVLA ALAILGTTLE
250 260 270 280 290 300
KIAVEIRHLQ RSEVREAMEP FGKGQTGSSS MPHKKNPILT ENVTGFARLL RGFLATGLEN
310 320 330 340 350 360
VALWHERDIS HSSAERVILP DATASASYAT RRLTGVLRDL VVFPERMLKN LDDLGGLVFS
370 380 390 400 410 420
QRVLHALIDD KGMMREAAYG IVQRNALKSW ETGEGLRDLL KADPENPLSD AELDAAFDLQ
430
WYLRHVDDIY ARFGM