Q9RA63

PR
Gene name
clpB (TTHA1487)
Protein name
Chaperone protein ClpB
Names
Species
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
KEGG Pathway
ttj:TTHA1487
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for Q9RA63

Entry ID Method Resolution Chain Position Source
1QVR X-ray 300 A A/B/C 1-854 PDB
4FCT X-ray 400 A A 545-852 PDB
4FCV X-ray 340 A A/B/C 544-852 PDB
4FCW X-ray 235 A A/C/F 544-852 PDB
4FD2 X-ray 300 A A/B/D 545-852 PDB
4HSE X-ray 220 A A 142-534 PDB
4LJ4 X-ray 280 A A 520-854 PDB
4LJ5 X-ray 240 A A 520-854 PDB
4LJ6 X-ray 190 A A 520-854 PDB
4LJ7 X-ray 280 A A/B/C 520-854 PDB
4LJ8 X-ray 210 A A 520-854 PDB
4LJ9 X-ray 170 A A 520-854 PDB
4LJA X-ray 200 A A 520-854 PDB
AF-Q9RA63-F1 Predicted AlphaFoldDB

No variants for Q9RA63

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9RA63

No associated diseases with Q9RA63

9 regional properties for Q9RA63

Type Name Position InterPro Accession
domain AAA+ ATPase domain 190 - 333 IPR003593-1
domain AAA+ ATPase domain 587 - 729 IPR003593-2
domain ATPase, AAA-type, core 195 - 325 IPR003959-1
domain ATPase, AAA-type, core 586 - 751 IPR003959-2
domain Clp, repeat (R) domain 3 - 147 IPR004176
conserved_site ClpA/B, conserved site 1 286 - 298 IPR018368
domain Clp ATPase, C-terminal 757 - 846 IPR019489
conserved_site ClpA/B, conserved site 2 621 - 639 IPR028299
domain ClpA/ClpB, AAA lid domain 333 - 435 IPR041546

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
identical protein binding Binding to an identical protein or proteins.

2 GO annotations of biological process

Name Definition
protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNLERWTQAA REALAQAQVL AQRMKHQAID LPHLWAVLLK DERSLAWRLL EKAGADPKAL
70 80 90 100 110 120
KELQERELAR LPKVEGAEVG QYLTSRLSGA LNRAEALMEE LKDRYVAVDT LVLALAEATP
130 140 150 160 170 180
GLPGLEALKG ALKELRGGRT VQTEHAESTY NALEQYGIDL TRLAAEGKLD PVIGRDEEIR
190 200 210 220 230 240
RVIQILLRRT KNNPVLIGEP GVGKTAIVEG LAQRIVKGDV PEGLKGKRIV SLQMGSLLAG
250 260 270 280 290 300
AKYRGEFEER LKAVIQEVVQ SQGEVILFID ELHTVVGAGK AEGAVDAGNM LKPALARGEL
310 320 330 340 350 360
RLIGATTLDE YREIEKDPAL ERRFQPVYVD EPTVEETISI LRGLKEKYEV HHGVRISDSA
370 380 390 400 410 420
IIAAATLSHR YITERRLPDK AIDLIDEAAA RLRMALESAP EEIDALERKK LQLEIEREAL
430 440 450 460 470 480
KKEKDPDSQE RLKAIEAEIA KLTEEIAKLR AEWEREREIL RKLREAQHRL DEVRREIELA
490 500 510 520 530 540
ERQYDLNRAA ELRYGELPKL EAEVEALSEK LRGARFVRLE VTEEDIAEIV SRWTGIPVSK
550 560 570 580 590 600
LLEGEREKLL RLEEELHKRV VGQDEAIRAV ADAIRRARAG LKDPNRPIGS FLFLGPTGVG
610 620 630 640 650 660
KTELAKTLAA TLFDTEEAMI RIDMTEYMEK HAVSRLIGAP PGYVGYEEGG QLTEAVRRRP
670 680 690 700 710 720
YSVILFDEIE KAHPDVFNIL LQILDDGRLT DSHGRTVDFR NTVIILTSNL GSPLILEGLQ
730 740 750 760 770 780
KGWPYERIRD EVFKVLQQHF RPEFLNRLDE IVVFRPLTKE QIRQIVEIQL SYLRARLAEK
790 800 810 820 830 840
RISLELTEAA KDFLAERGYD PVFGARPLRR VIQRELETPL AQKILAGEVK EGDRVQVDVG
850
PAGLVFAVPA RVEA