Q9R1N2

PR
Gene name
SCNN1A (ENAC)
Protein name
Amiloride-sensitive sodium channel subunit alpha
Names
Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA
Species
Cavia porcellus (Guinea pig)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

5-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9R1N2

Entry ID Method Resolution Chain Position Source
AF-Q9R1N2-F1 Predicted AlphaFoldDB

No variants for Q9R1N2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9R1N2

No associated diseases with Q9R1N2

1 regional properties for Q9R1N2

Type Name Position InterPro Accession
conserved_site Epithelial sodium channel, conserved site 435 - 455 IPR020903

Functions

Description
EC Number
Subcellular Localization
  • Apical cell membrane ; Multi-pass membrane protein
  • Cell projection, cilium
  • Cytoplasmic granule
  • Cytoplasm
  • Cytoplasmic vesicle, secretory vesicle, acrosome
  • Cell projection, cilium, flagellum
  • In the oviduct and bronchus, located on cilia in multi-ciliated cells
  • In endometrial non-ciliated epithelial cells, restricted to apical surfaces
  • In epidermis, located nearly uniformly in the cytoplasm in a granular distribution
  • In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles
  • In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen
  • In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
ciliary membrane The portion of the plasma membrane surrounding a cilium.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
sodium channel complex An ion channel complex through which sodium ions pass.
sperm principal piece The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.

1 GO annotations of molecular function

Name Definition
ligand-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

5 GO annotations of biological process

Name Definition
multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism.
response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
sensory perception of taste The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.
sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLMRLLPLPS LTDGRPLGCC CTCQGSMKGD ELKAQGPLPP QPLQGPLKGD KCEQPGLGPE
70 80 90 100 110 120
PTAPQQHTEE EEALIEFHRS YRELFQFFCN NTTIHGAIRL VCSKHNRMKT AFWAVLWLCT
130 140 150 160 170 180
FGMMYWQFAL LFGEYFSYPV SLNINLNSDK LVFPAVTVCT LNPYRYKEIK EQLRELDRIT
190 200 210 220 230 240
QQTLFDLYNY NASSTLLAGA RSRRSLADTL PYPLQRIPVQ PEPRRARSSD PSSVRDNNPR
250 260 270 280 290 300
VDRRDWRVGF QLCNQNKSDC FYQTSSSGVD GVREWYRFHY INILAQVADT SPRWEEETLG
310 320 330 340 350 360
NFIFACRFNQ APCTQENYSH FHHPIYGNCY TFNNKNDSSL WMASMPGINN GLSLTLRTEQ
370 380 390 400 410 420
NDYIPLLSTV TGARVTVHGQ DEPAFMDDGG FNLRPGVETS ISMRKEALDR LGGSYGDCTQ
430 440 450 460 470 480
DGSDVPVQNL YPSKYTQQVC IHSCFQENMI KQCGCAYIFY PKPKGVEFCD YTNHSAWGYC
490 500 510 520 530 540
YYKLQGAFSS DSLGCFNKCR KPCNVTIYKL SAGYSRWPSA ASQDWIFQML SLQNNYTISN
550 560 570 580 590 600
KRNGVAKLNI YFKELNYRTN SESPSVTMVT LLSNLGSQWS LWFGSSVLSV VEMAEFMFDL
610 620 630 640 650 660
LVITLLMLLR RFRSRYWSPG RGARAAREVA CTPPPSLPSR FCAHSAFPTL TAPPPAYATL
670 680
SACPPLQGLA GASSAACAPR EP