Q9R1A3
Gene name |
Ntn3 (Ntn2l) |
Protein name |
Netrin-3 |
Names |
Netrin-2-like protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:18209 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R1A3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R1A3-F1 | Predicted | AlphaFoldDB |
27 variants for Q9R1A3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs387041844 | 23 | L>P | No | EVA | |
| rs3389398063 | 36 | E>G | No | EVA | |
| rs221641858 | 100 | Q>R | No | EVA | |
| rs250115762 | 155 | T>S | No | EVA | |
| rs3389431445 | 173 | P>L | No | EVA | |
| rs3389353626 | 207 | N>K | No | EVA | |
| rs3389418111 | 210 | V>L | No | EVA | |
| rs215473976 | 215 | V>M | No | EVA | |
| rs3389441787 | 229 | I>F | No | EVA | |
| rs252155751 | 234 | R>S | No | EVA | |
| rs3389407146 | 248 | E>V | No | EVA | |
| rs233381196 | 270 | G>D | No | EVA | |
| rs3389433225 | 278 | H>Q | No | EVA | |
| rs3389430720 | 365 | L>M | No | EVA | |
| rs3389441827 | 376 | C>R | No | EVA | |
| rs3389407103 | 378 | P>A | No | EVA | |
| rs3407547274 | 414 | S>N | No | EVA | |
| rs3389449720 | 442 | E>G | No | EVA | |
| rs3389407096 | 454 | I>F | No | EVA | |
| rs234426043 | 473 | R>L | No | EVA | |
| rs3389431372 | 481 | T>R | No | EVA | |
| rs3389407109 | 488 | L>I | No | EVA | |
| rs3389431391 | 488 | L>R | No | EVA | |
| rs3389407087 | 489 | A>D | No | EVA | |
| rs3389444390 | 491 | F>C | No | EVA | |
| rs3389449696 | 491 | F>L | No | EVA | |
| rs3389387663 | 492 | R>S | No | EVA |
No associated diseases with Q9R1A3
6 regional properties for Q9R1A3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Netrin domain | 441 - 577 | IPR001134 |
| domain | Laminin-type EGF domain | 254 - 308 | IPR002049-1 |
| domain | Laminin-type EGF domain | 310 - 371 | IPR002049-2 |
| domain | Laminin-type EGF domain | 373 - 423 | IPR002049-3 |
| domain | Laminin, N-terminal | 34 - 254 | IPR008211 |
| domain | Netrin module, non-TIMP type | 456 - 571 | IPR018933 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| basement membrane | A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| animal organ morphogenesis | Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. |
| axonogenesis | De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. |
| dendrite development | The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. |
| motor neuron axon guidance | The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| myoblast fusion | A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| tissue development | The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPTWLWGLLL | TAGTLSAALS | PGLPASADPC | YDEAREPRSC | IPGLVNAALG | REVLASSTCG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RSANRVCDSS | DPQRAHSADL | LTSAPGTASP | LCWRSDLLQQ | APFNVTLTVP | LGKAFELVFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLRFCSAPPT | SVALLKSQDH | GRSWVPLGFF | SSSCTLDYGR | LPAPADGPSG | PGPEALCFPA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PQAQPDGGGL | LAFSVQDGSP | QGLDLDNSPV | LQDWVTATDI | RIVLTRPAIQ | GDTRDGGVTV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYSYSATELQ | VGGRCKCNGH | ASRCLLDTHG | HLVCDCQHGT | EGPDCSRCKP | FYCDRPWQRA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TGQEAHACLA | CSCNGHARRC | RFNMELYRLS | GRRSGGVCLN | CRHNTAGRHC | HYCREGFYRD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PGRVLSDRRA | CRACDCHPVG | AAGKTCNQTT | GQCPCKDGVT | GLTCNRCAPG | FQQSRSPVAP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| CVKTPVPGPT | EESSPVEPQD | CESHCRPARG | SYRISLKKFC | RKDYAVQVAV | GARGEARGSW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TRFPVAVLAV | FRSGEERARR | GSSALWVPTL | DAACGCPRLL | PGRRYLLLGG | GPGAAAGSTA |
| 550 | 560 | 570 | |||
| GRGQGLSAAR | GSLVLPWRDA | WTRRLRRLQR | RERRGRCGTA |