Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9R0I7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9R0I7-F1 | Predicted | AlphaFoldDB |
44 variants for Q9R0I7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389249454 | 74 | Q>* | No | EVA | |
| rs3389258236 | 101 | W>G | No | EVA | |
| rs3403523261 | 102 | Q>R | No | EVA | |
| rs3389225199 | 115 | A>S | No | EVA | |
| rs3389260303 | 135 | G>R | No | EVA | |
| rs3389243769 | 155 | P>S | No | EVA | |
| rs3403502937 | 295 | E>V | No | EVA | |
| rs3389252686 | 305 | P>T | No | EVA | |
| rs253971380 | 339 | Q>R | No | EVA | |
| rs3389219334 | 353 | H>Q | No | EVA | |
| rs3389245710 | 355 | Q>* | No | EVA | |
| rs52178601 | 368 | G>E | No | EVA | |
| rs3389249516 | 378 | Q>* | No | EVA | |
| rs3389210402 | 410 | Q>H | No | EVA | |
| rs3389265607 | 434 | P>S | No | EVA | |
| rs3389253543 | 459 | Y>N | No | EVA | |
| rs3389253486 | 469 | T>N | No | EVA | |
| rs3389249514 | 497 | M>L | No | EVA | |
| rs3389260319 | 537 | V>D | No | EVA | |
| rs3389260364 | 578 | P>S | No | EVA | |
| rs3389252681 | 595 | P>S | No | EVA | |
| rs265146298 | 645 | Y>F | No | EVA | |
| rs3389252741 | 648 | P>S | No | EVA | |
| rs243895505 | 679 | I>V | No | EVA | |
| rs3389225259 | 702 | L>M | No | EVA | |
| rs3413127726 | 789 | P>S | No | EVA | |
| rs3389243753 | 795 | P>Q | No | EVA | |
| rs3389249068 | 797 | P>S | No | EVA | |
| rs251018208 | 798 | P>L | No | EVA | |
| rs3389260326 | 842 | A>T | No | EVA | |
| rs3389181849 | 892 | T>S | No | EVA | |
| rs3389225236 | 894 | K>E | No | EVA | |
| rs3389248443 | 915 | S>T | No | EVA | |
| rs236626810 | 922 | A>V | No | EVA | |
| rs3389225229 | 973 | F>V | No | EVA | |
| rs3389245741 | 1041 | G>D | No | EVA | |
| rs3389248363 | 1110 | S>N | No | EVA | |
| rs3389210379 | 1153 | M>T | No | EVA | |
| rs3389245725 | 1162 | D>E | No | EVA | |
| rs3389181787 | 1165 | F>L | No | EVA | |
| rs3389210339 | 1200 | M>T | No | EVA | |
| rs3389181780 | 1236 | R>C | No | EVA | |
| rs3389219301 | 1279 | Y>F | No | EVA | |
| rs3389265518 | 1356 | I>L | No | EVA |
No associated diseases with Q9R0I7
No regional properties for Q9R0I7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9R0I7 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription repressor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| regulation of telomere maintenance | Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYPNWGRYGG | SSHYPPPPVP | PPPPPVALPE | ASPGPGYSSS | TAPAAPSSSG | FMSFREQHLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLQQLQQMHQ | KQMQCVLQPH | HLPPPPLPPP | PVMPGGGYGD | WQPPPPPMPP | PPGPALSYQK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QQQYKHQMIH | HQRDGPPGLV | PMELESPPES | PPVPPGSYMP | PSQSYMPPPQ | PPPSYYPPSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AQPYLPPAQP | GPSKPQLPPP | PSIPSGNKTA | IQQEPLESGA | KNKTAEQKQA | APEPDPSTMT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PQEQQQYWYR | QHLLSLQQRT | KVHLPGHKKG | LVTAKDVPEP | IKEEAPGPAA | SQVAEPLAAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPPLPPPNEE | APPPLSPEEP | QSEDSEDSED | SEEDARFKQL | KAIAAHWQAA | AAHWQQQQQQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RVGFQYQGIM | QRHTQLQQIL | QQYQQVIQHS | PHIQTMSLDV | QLRHYEMQQQ | QFQHLFQDWE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| REFQLWEEQL | HSYPHKDQLQ | EYEKQWKTWQ | GHMKATQTYL | QEKVNSFQTV | KSQYLGNMAM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPPFVPYSQM | PPPLPTMPPP | VLPPSLPPPV | MPPALPTSIP | PPGMPPPVMP | PSLPTSVPPP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GMPPSLSSGP | PPVLPPPALS | SAGSPPVLPP | PALPGGPPIL | PLPPLSSATP | PPGIPPPGAP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QGMPPQLTAP | LPPASGSQNS | QIPEKPRQAL | LPTPVSFGST | PPSPYHPPPQ | SEQVNSKPLN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KVFSSEQGLG | ESSALSQSII | AAKDTPVKSG | GLLADPPKGS | FLEGPRGPRE | QKEQLQKLKD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| FGSEPQMADH | LPPPDSRLQN | PSRPGMYPPP | GSYRPPPPMG | KPPGSIVRPS | APPARSSIPM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TRPPVPIPPP | PPPPPPPPPP | PPVIKSKTSS | VKQERWDEDS | FFGLWDTNDD | QGLNSEFKRD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TATIPSAPVL | PPPPVHSSIP | PPGPMPMGMP | PMSKPPPVQH | TVDYGHGRDM | PTNKVEQIPY |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GERITLRPDP | LPERSTFDAD | HAGQRDRYDR | DRDREPYFDR | PSNITDHRDF | KRDRETHRDR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DRDRVLDYER | DRFDRERRPR | DDRNQSYRDK | KDHSSSRRGG | FDRPSYDRKS | DRPPYEGPPM |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FGGERRTYPE | ERMPLPAPAL | GHQPPPVPRV | EKKPESKNVD | DILKPPGRES | RPERIVVIMR |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GLPGSGKTHV | AKLIRDKEVE | FGGPAPRVLS | LDDYFIAEVE | KEEKDPDSGK | KVKKKVMEYE |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YEADMEETYR | TSMFKTFKKT | LDDGFFPFII | LDAINDRVRH | FDQFWSAAKT | KGFEVYLAEM |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SADNQTCGKR | NIHGRKLKEI | NKMAEHWEVA | PRHMMRLDIR | SLLQDAAIEE | VEMEDFDANI |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EDQKEEKKDA | EEEESELGYI | PKSKWEMDTS | EAKLDKLDGL | RTGTKRKRDW | EAIASRMEDY |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LQLPDDYETR | ASEPGKKRVR | WADLEEKKDA | DRKRAIGFVV | GQTDWEKITD | ESGHLAERAL |
| NRTKYI |