AiPD: Autoinhibited Protein Database

Gene name	Tbl2
Protein name	Transducin beta-like protein 2
Names
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:27368
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

380-442 (Predicted disordered autoinhibitory region) PR

380-442 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9R099-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs230785214	44	Q>L	No	EVA
rs245033064	60	N>T	No	EVA
rs257872324	74	T>M	No	EVA
rs3388796662	143	D>G	No	EVA
rs3388783826	165	R>W	No	EVA
rs3388794803	218	L>R	No	EVA
rs240967829	219	S>A	No	EVA
rs3388783772	227	N>K	No	EVA
rs3388804393	248	D>N	No	EVA
rs3388804371	289	R>G	No	EVA
rs3388790610	305	D>Y	No	EVA
rs3388778834	309	K>*	No	EVA
rs3388797626	317	L>I	No	EVA
rs3388790663	369	E>G	No	EVA
rs254006661	382	F>L	No	EVA
rs3388799433	394	F>L	No	EVA
rs3388768329	396	N>T	No	EVA
rs3388796696	418	S>N	No	EVA
rs3388793275	428	T>I	No	EVA
rs3396211405	431	Q>H	No	EVA
rs3388778831	431	Q>L	No	EVA
rs3388778831	431	Q>P	No	EVA
rs3396301512	433	A>G	No	EVA
rs3396009482	436	S>G	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	75 - 114	IPR001680-1
repeat	WD40 repeat	173 - 214	IPR001680-2
repeat	WD40 repeat	214 - 253	IPR001680-3
repeat	WD40 repeat	264 - 303	IPR001680-4
repeat	WD40 repeat	358 - 395	IPR001680-5
conserved_site	WD40 repeat, conserved site	199 - 213	IPR019775
repeat	G-protein beta WD-40 repeat	101 - 115	IPR020472-1
repeat	G-protein beta WD-40 repeat	199 - 213	IPR020472-2
repeat	G-protein beta WD-40 repeat	290 - 304	IPR020472-3

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
endoplasmic reticulum	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

Name	Definition
phosphoprotein binding	Binding to a phosphorylated protein.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
translation initiation factor binding	Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.

Name	Definition
cellular response to glucose starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
cellular response to hypoxia	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
endoplasmic reticulum unfolded protein response	The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y4P3	TBL2	Transducin beta-like protein 2	Homo sapiens (Human)	PR