Q9QUM7

PR
Gene name
Msh5
Protein name
MutS protein homolog 5
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:17687
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

748-826 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QUM7

Entry ID Method Resolution Chain Position Source
AF-Q9QUM7-F1 Predicted AlphaFoldDB

No variants for Q9QUM7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9QUM7

No associated diseases with Q9QUM7

3 regional properties for Q9QUM7

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 584 - 775 IPR000432
domain DNA mismatch repair protein MutS, core 225 - 568 IPR007696
domain DNA mismatch repair protein MutS, clamp 397 - 495 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
synaptonemal complex A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

5 GO annotations of biological process

Name Definition
chiasma assembly The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.
female gamete generation Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
homologous chromosome pairing at meiosis The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
meiosis I The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei.
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43196 MSH5 MutS protein homolog 5 Homo sapiens (Human) PR
10 20 30 40 50 60
MAFRATPGRT PPGPGPRSGI PSASFPSPQP PMAGPGGIEE EDEEEPAEIH LCVLWSSGYL
70 80 90 100 110 120
GIAYYDTSDS TIHFMPDAPD HESLKLLQRV LDEINPQSVV TSAKQDEAMT RFLGKLASEE
130 140 150 160 170 180
HREPKGPEII LLPSVDFGPE ISKQRLLSGN YSFISDSMTA TEKILFLSSI IPFDCVLTVR
190 200 210 220 230 240
ALGGLLKFLS RRRIGVELED YDVGVPILGF KKFVLTHLVS IDQDTYSVLQ IFKSESHPSV
250 260 270 280 290 300
YKVASGLKEG LSLFGILNRC RCKWGQKLLR LWFTRPTREL RELNSRLDVI QFFLMPQNLD
310 320 330 340 350 360
MAQMLHRLLS HIKNVPLILK RMKLSHTKVS DWQVLYKTVY SALGLRDACR SLPQSIQLFQ
370 380 390 400 410 420
DIAQEFSDDL HHIASLIGKV VDFEESLAEN RFTVLPNIDP DIDAKKRRLI GLPSFLTEVA
430 440 450 460 470 480
QKELENLDSR IPSCSVIYIP LIGFLLSIPR LPFMVEASDF EIEGLDFMFL SEDKLHYRSA
490 500 510 520 530 540
RTKELDTLLG DLHCEIRDQE TLLMYQLQCQ VLARASVLTR VLDLASRLDV LLALASAARD
550 560 570 580 590 600
YGYSRPHYSP CIHGVRIRNG RHPLMELCAR TFVPNSTDCG GDQGRVKVIT GPNSSGKSIY
610 620 630 640 650 660
LKQVGLITFM ALVGSFVPAE EAEIGVIDAI FTRIHSCESI SLGLSTFMID LNQVAKAVNN
670 680 690 700 710 720
ATEHSLVLID EFGKGTNSVD GLALLAAVLR HWLALGPSCP HVFVATNFLS LVQLQLLPQG
730 740 750 760 770 780
PLVQYLTMET CEDGEDLVFF YQLCQGVASA SHASHTAAQA GLPDPLIARG KEVSDLIRSG
790 800 810 820 830
KPIKATNELL RRNQMENCQA LVDKFLKLDL EDPTLDLDIF ISQEVLPAAP TIL