Q9QUM4

PR
Gene name
Slamf1 (Slam)
Protein name
Signaling lymphocytic activation molecule
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27218
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-322 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9QUM4

Entry ID Method Resolution Chain Position Source
AF-Q9QUM4-F1 Predicted AlphaFoldDB

27 variants for Q9QUM4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388516701 12 L>P No EVA
rs3388513999 36 L>I No EVA
rs224105047 69 T>K No EVA
rs3388513845 88 S>G No EVA
rs3388517572 90 P>S No EVA
rs3390905654 101 S>A No EVA
rs3388518863 104 L>M No EVA
rs3388516430 110 G>E No EVA
rs3388516982 112 R>G No EVA
rs3388516967 114 E>V No EVA
rs3388513808 125 E>K No EVA
rs3388518877 126 N>Y No EVA
rs3388517520 144 P>T No EVA
rs3388514157 184 G>D No EVA
rs3388513994 211 N>I No EVA
rs260037896 221 I>L No EVA
rs228613136 221 I>S No EVA
rs254008487 244 M>I No EVA
rs213334742 246 Y>N No EVA
rs252517540 254 V>I No EVA
rs3388516674 266 M>L No EVA
rs239601061 273 S>P No EVA
rs3390989875 277 Q>* No EVA
rs3390903139 277 Q>R No EVA
rs263979481 323 P>S No EVA
rs3388511834 326 V>I No EVA
rs3388511852 331 P>S No EVA

No associated diseases with Q9QUM4

2 regional properties for Q9QUM4

Type Name Position InterPro Accession
domain Immunoglobulin-like domain 145 - 228 IPR007110
domain Signaling lymphocytic activation molecule, N-terminal 1 - 126 IPR010407

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Present on the surface of B-cells and T-cells
  • Located at the plasma membrane contacts between neighboring T cells
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
SH2 domain binding Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

23 GO annotations of biological process

Name Definition
adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
leukocyte chemotaxis involved in inflammatory response The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.
myeloid dendritic cell activation involved in immune response The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
natural killer cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.
natural killer cell proliferation The expansion of a natural killer cell population by cell division.
negative regulation of CD40 signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway.
negative regulation of interferon-gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.
negative regulation of interleukin-6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
negative regulation of T cell cytokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.
negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of activated T cell proliferation Any process that activates or increases the rate or extent of activated T cell proliferation.
positive regulation of dendritic cell chemotaxis Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of macrophage chemotaxis Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
positive regulation of T-helper 1 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production.
regulation of catalytic activity Any process that modulates the activity of an enzyme.
regulation of vesicle fusion Any process that modulates the frequency, rate or extent of vesicle fusion.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UIB8 CD84 SLAM family member 5 Homo sapiens (Human) PR
10 20 30 40 50 60
MDPKGSLSWR ILLFLSLAFE LSYGTGGGVM DCPVILQKLG QDTWLPLTNE HQINKSVNKS
70 80 90 100 110 120
VRILVTMATS PGSKSNKKIV SFDLSKGSYP DHLEDGYHFQ SKNLSLKILG NRRESEGWYL
130 140 150 160 170 180
VSVEENVSVQ QFCKQLKLYE QVSPPEIKVL NKTQENENGT CSLLLACTVK KGDHVTYSWS
190 200 210 220 230 240
DEAGTHLLSR ANRSHLLHIT LSNQHQDSIY NCTASNPVSS ISRTFNLSSQ ACKQESSSES
250 260 270 280 290 300
SPWMQYTLVP LGVVIIFILV FTAIIMMKRQ GKSNHCQPPV EEKSLTIYAQ VQKSGPQEKK
310 320 330 340
LHDALTDQDP CTTIYVAATE PAPESVQEPN PTTVYASVTL PES