Q9PZT0

PR
Gene name
vp
Protein name
Minor capsid protein VP1
Names
Coat protein VP1
Species
Human parvovirus B19 (strain HV) (HPV B19)
KEGG Pathway
vg:11293627
EC number
3.1.1.4: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9PZT0

Entry ID Method Resolution Chain Position Source
1S58 X-ray 350 A A 1-554 PDB

No variants for Q9PZT0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9PZT0

No associated diseases with Q9PZT0

2 regional properties for Q9PZT0

Type Name Position InterPro Accession
domain Parvovirus coat protein VP2 237 - 746 IPR001403
domain Phospholipase A2-like domain 122 - 200 IPR013607

Functions

Description
EC Number 3.1.1.4 Carboxylic ester hydrolases
Subcellular Localization
  • [Isoform Minor capsid protein VP1]: Virion
  • Host nucleus
  • Host cytoplasm
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
host cell cytoplasm The cytoplasm of a host cell.
host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.
T=1 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.
viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
phospholipase A2 activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

7 GO annotations of biological process

Name Definition
clathrin-dependent endocytosis of virus by host cell Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
microtubule-dependent intracellular transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules.
permeabilization of host organelle membrane involved in viral entry into host cell Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.
receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface.
viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane.
viral penetration into host nucleus The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKESGKWWE SDDKFAKAVY QQFVEFYEKV TGTDLELIQI LKDHYNISLD NPLENPSSLF
70 80 90 100 110 120
DLVARIKNNL KNSPDLYSHH FQSHGQLSDH PHALSSSSSH AEPRGENAVL SSEDLHKPGQ
130 140 150 160 170 180
VSVQLPGTNY VGPGNELQAG PPQSAVDSAA RIHDFRYSQL AKLGINPYTH WTVADEELLK
190 200 210 220 230 240
NIKNETGFQA QVVKDYFTLK GAAAPVAHFQ GSLPEVPAYN ASEKYPSMTS VNSAEASTGA
250 260 270 280 290 300
GGGGSNPVKS MWSEGATFSA NSVTCTFSRQ FLIPYDPEHH YKVFSPAASS CHNASGKEAK
310 320 330 340 350 360
VCTISPIMGY STPWRYLDFN ALNLFFSPLE FQHLIENYGS IAPDALTVTI SEIAVKDVTD
370 380 390 400 410 420
KTGGGVQVTD STTGRLSMLV DHEYKYPYVL GQGQDTLAPE LPIWVYFPPQ YAYLTVGDVN
430 440 450 460 470 480
TQGISGDSKK LASEESAFYV LEHSSFQLLG TGGTATMSYK FPPVPPENLE GCSQHFYEMY
490 500 510 520 530 540
NPLYGSRLGV PDTLGGDPKF RSLTHEDHAI QPQNFMPGPL VNSVSTKEGD SSNTGAGKAL
550 560 570 580 590 600
TGLSTGTSQN TRISLRPGPV SQPYHHWDTD KYVPGINAIS HGQTTYGNAE DKEYQQGVGR
610 620 630 640 650 660
FPNEKEQLKQ LQGLNMHTYF PNKGTQQYTD QIERPLMVGS VWNRRALHYE SQLWSKIPNL
670 680 690 700 710 720
DDSFKTQFAA LGGWGLHQPP PQIFLKILPQ SGPIGGIKSM GITTLVQYAV GIMTVTMTFK
730 740 750 760 770 780
LGPRKATGRW NPQPGVYPPH AAGHLPYVLY DPTATDAKQH HRHGYEKPEE LWTAKSRVHP
L