Q9PVX8

PR
Gene name
stat3.1 (stat3)
Protein name
Signal transducer and activator of transcription 3.1
Names
Protein Stat3, Xstat3
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:779100
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

90-232 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9PVX8

Entry ID Method Resolution Chain Position Source
AF-Q9PVX8-F1 Predicted AlphaFoldDB

No variants for Q9PVX8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9PVX8

No associated diseases with Q9PVX8

4 regional properties for Q9PVX8

Type Name Position InterPro Accession
domain ATP-citrate lyase/succinyl-CoA ligase 260 - 376 IPR005811
domain ATP-grasp fold 9 - 245 IPR011761
domain ATP-grasp fold, succinyl-CoA synthetase-type 2 - 196 IPR013650
conserved_site Succinyl-CoA synthetase, beta subunit, conserved site 253 - 278 IPR017866

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Shuttles between the nucleus and the cytoplasm
  • Constitutive nuclear presence is independent of tyrosine phosphorylation (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

10 GO annotations of biological process

Name Definition
eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.
eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.
glucose homeostasis Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.
mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
positive regulation of DNA-templated transcription Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
sexual reproduction A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).
temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAFAASKE SHATLVFHNL
70 80 90 100 110 120
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EEGRLLQTAA
130 140 150 160 170 180
AAAQQGGPAS HPNAAVVTEK QQMLEQHLQD VRKKVQDLEQ KMKVVENLQD DFDFNYKTLK
190 200 210 220 230 240
SQSDLSELNG NNQSVTRQKM QQLEQMLTAL DQLRRTIISD LASLLSAMEY VQKTLTDEEL
250 260 270 280 290 300
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQIRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350 360
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTNKVR LLVKFPELNY
370 380 390 400 410 420
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
430 440 450 460 470 480
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
490 500 510 520 530 540
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
550 560 570 580 590 600
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650 660
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNNMSF AEIIMGYKIM
670 680 690 700 710 720
DATNILVSPL VYLYPDIPKE EAFGKYCRPE SQEHQEPTDP GSTAPYLKTK FICVTPTTCS
730 740 750 760
STLDLPMSPR TLDSLMQFPG EGADSSAGNQ FETLTFDMEL TSECASSPM