Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9PVE2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9PVE2-F1 | Predicted | AlphaFoldDB |
No variants for Q9PVE2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9PVE2 | |||||
No associated diseases with Q9PVE2
No regional properties for Q9PVE2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9PVE2 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| nuclear estrogen receptor activity | Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. |
| nuclear receptor activity | A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| steroid binding | Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to estradiol stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| intracellular estrogen receptor signaling pathway | The series of molecular signals initiated by estrogen binding to an intracellular receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLCTSSHKD | FSQLLPLQDI | GCNKTEIKNS | PAGVISPAPY | SCNQSTLTAE | HSPVYIPSSY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MESRHEYSTM | AFCSPAMVNY | NIASNFGDPE | AVAARQTSSP | GALWSAPGHL | SPLSLHCQSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLYAEQPKSL | WCEARPMEPV | LPGSRETLKR | KTNGNDCTSP | IANNPGSKKD | AHFCAVCSDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASGYHYGVWS | CEGCKAFFKR | SIQGHNDYIC | PATNQCTIDK | NRRKSCQACR | LRKCYEVGMM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KCGSRRERCG | YRILRSHRGA | EERVHCLGRA | RRYSEAATRV | KEILLSTVSP | EQFVLTLLEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPPHVLVSRP | SKPFTEASMM | MSLTKLADKE | LVHMIGWAKK | IPGFIDLSLY | DQVRLLESCW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MEVLMIGLMW | RSIDHPGKLI | FAPDLVLDRD | EGKCVEGILE | IFDMLLAMTS | RFRELKLQHK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYLCVKAMIL | LNSSMFPLSA | EEPESNRKLH | HLLNVVTEAL | VWVIAKSGIP | SQQQTTRLAN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LLMLLSHVRH | ASNKGMEHLL | SMKCKNVVPV | YDLLLEMLNA | HTLRGQRKPL | ATHPEFGPLE |
| 550 | |||||
| QMEPGESLRK | GEPQ |