Q9PUQ1
SS
Gene name |
etv4 (pea3) |
Protein name |
ETS translocation variant 4 |
Names |
Polyomavirus enhancer activator 3 homolog , Protein PEA3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
|
EC number |
2.7.11.25: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the c-Jun N-terminal kinase (JNK) pathway through the dual phosphorylation of mitogen-activated protein kinase kinases 4/7 (MKK4/7). The catalytic domain of MLK3 is flanked by an N-terminal SH3 domain and a centrally located zipper and Cdc42/Rac-interactive binding (CRIB) motif. Zipper-mediated homo-oligomerization is required for full activity of MLK3, proper substrate phosphorylation, and activation of the JNK pathway. MLK3 is autoinhibited through an interaction between its SH3 domain and a proline-containing sequence between the zipper and the CRIB motif. Activated forms of the small GTPases Cdc42 and Rac interact with MLK3 in a CRIB motif-dependent manner to increase the autophosphorylation of MLK3 and substrate phosphorylation activity and to potentiate MLK3-induced activation of JNK. Activated Cdc42 translocates MLK3 to membranes and induces activation loop phosphorylation of MLK3.
Autoinhibitory domains (AIDs)
Target domain |
346-439 (ETS domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9PUQ1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9PUQ1-F1 | Predicted | AlphaFoldDB |
No variants for Q9PUQ1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9PUQ1 | |||||
No associated diseases with Q9PUQ1
1 regional properties for Q9PUQ1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Centrosomal protein of 290kDa, coiled-coil region | 1283 - 1410 | IPR032321 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.25 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| limb morphogenesis | The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| pronephric nephron tubule epithelial cell differentiation | The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state. |
| pronephros development | The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A1A4L6 | ETS2 | Protein C-ets-2 | Bos taurus (Bovine) | SS |
| Q2KIC2 | ETV1 | ETS translocation variant 1 | Bos taurus (Bovine) | SS |
| P15062 | ETS1 | Transforming protein p68/c-ets-1 | Gallus gallus (Chicken) | SS |
| P10157 | ETS2 | Protein C-ets-2 | Gallus gallus (Chicken) | SS |
| Q90837 | ERG | Transcriptional regulator Erg | Gallus gallus (Chicken) | SS |
| A2T762 | ETV3 | ETS translocation variant 3 | Pan troglodytes (Chimpanzee) | PR |
| Q04688 | Ets97D | DNA-binding protein Ets97D | Drosophila melanogaster (Fruit fly) | PR |
| P50548 | ERF | ETS domain-containing transcription factor ERF | Homo sapiens (Human) | PR |
| P41970 | ELK3 | ETS domain-containing protein Elk-3 | Homo sapiens (Human) | SS |
| P41161 | ETV5 | ETS translocation variant 5 | Homo sapiens (Human) | SS |
| Q06546 | GABPA | GA-binding protein alpha chain | Homo sapiens (Human) | SS |
| P28324 | ELK4 | ETS domain-containing protein Elk-4 | Homo sapiens (Human) | EV |
| P15036 | ETS2 | Protein C-ets-2 | Homo sapiens (Human) | EV |
| P41162 | ETV3 | ETS translocation variant 3 | Homo sapiens (Human) | PR |
| P14921 | ETS1 | Protein C-ets-1 | Homo sapiens (Human) | EV |
| P50549 | ETV1 | ETS translocation variant 1 | Homo sapiens (Human) | EV |
| P11308 | ERG | Transcriptional regulator ERG | Homo sapiens (Human) | EV |
| P19419 | ELK1 | ETS domain-containing protein Elk-1 | Homo sapiens (Human) | EV |
| P43268 | ETV4 | ETS translocation variant 4 | Homo sapiens (Human) | EV |
| P41971 | Elk3 | ETS domain-containing protein Elk-3 | Mus musculus (Mouse) | EV |
| Q00422 | Gabpa | GA-binding protein alpha chain | Mus musculus (Mouse) | EV |
| P41969 | Elk1 | ETS domain-containing protein Elk-1 | Mus musculus (Mouse) | PR |
| P15037 | Ets2 | Protein C-ets-2 | Mus musculus (Mouse) | SS |
| P27577 | Ets1 | Protein C-ets-1 | Mus musculus (Mouse) | EV |
| P70459 | Erf | ETS domain-containing transcription factor ERF | Mus musculus (Mouse) | PR |
| Q9CXC9 | Etv5 | ETS translocation variant 5 | Mus musculus (Mouse) | SS |
| P41158 | Elk4 | ETS domain-containing protein Elk-4 | Mus musculus (Mouse) | PR |
| P41164 | Etv1 | ETS translocation variant 1 | Mus musculus (Mouse) | SS |
| P81270 | Erg | Transcriptional regulator ERG | Mus musculus (Mouse) | SS |
| P28322 | Etv4 | ETS translocation variant 4 | Mus musculus (Mouse) | SS |
| P41156 | Ets1 | Protein C-ets-1 | Rattus norvegicus (Rat) | SS |
| A4GTP4 | Elk1 | ETS domain-containing protein Elk-1 | Rattus norvegicus (Rat) | PR |
| A3FEM2 | fev | Protein FEV | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESSRSLLGC | LASATAAPPG | DDATGAGAEE | EEDEEEAAAE | LGSHAALPYW | TAVFEYEAAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDELTLRLGD | VVEVLSKDSQ | VSGDEGWWTG | QLNQRVGIFP | SNYVTPRSAF | SSRCQPGAED |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSCYPPIQLL | EIDFAELTLE | EIIGIGGFGK | VYRAFWAGDE | VAVKAARHDP | DEDISQTIEN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VRQEAKLFAM | LKHPNIIALR | GVCLKEPNLC | LVMEFARGGP | LNRVLSGKRI | PPDILVNWAV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QIARGMNYLH | DEAIVPIIHR | DLKSSNILIL | QKVENGDLSN | KILKITDFGL | AREWHRTTKM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SAAGTYAWMA | PEVIRASMFS | KGSDVWSYGV | LLWELLTGEV | PFRGIDGLAV | AYGVAMNKLA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPIPSTCPEP | FAKLMEDCWN | PDPHSRPSFT | SILDQLTTIE | ESGFFEMPKD | SFHCLQDDWK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HEIQEMFDQL | RAKEKELRTW | EEELTRAALQ | QKNQEELLRR | REQELAEREI | DILERELNII |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IHQLCQEKPR | VKKRKGKFRK | SRLKLKDGNR | ISLPSDFQHK | FTVQASPTMD | KRKSLISNRS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SPPASPTIIP | RLRAIQLTPG | ESSKTWGRSS | VVPKEEGEEE | EKRAPKKKGR | TWGPGTLGQK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELTSGDEGLK | SLVDGYKQWS | SSAPNLGKGP | RSSPALPGFT | SLMEIEDEDS | EGPGSGENHQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QHSPNQSYLC | IPFPRGEDGD | GPSSDGVHEE | PTPVNSATST | PQLTPTNSLK | RGGTHHRRCE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VALLGCGAVL | AATGLGFDLL | EAGKCQLLPP | EEPEPPAREE | KKRREGLFQR | ASRPRRSTSP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PSRKLFKKEE | PMTLLGDPSA | SLTLLSLSSI | SECNSTRSLL | RSDSDEIVVY | EMPVSPVEAP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PLTQCTHNPL | VNVRVERFKR | DPNQSLTPTH | VTLTAPTQPS | GHRRTPSDGA | LKPTAAPAVL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GSRSPSSNGM | SPSPGTGMLK | TPSPSRDPGE | FPRLPDPNVV | FPPTPRRWNT | QRDSTLERPK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TLEFLPRPRP | SANRQRLDPW | WFVSPSHARS | ASPANSSSTE | TPSNLDSCFA | SSSSTVEERP |
| 1030 | 1040 | 1050 | 1060 | 1070 | |
| GLPALLPLQA | GPLLPAERTL | LDLDAEGQSQ | DSTVPLCRAE | LNAHGPSPYE | IQQEFWS |