Q9PPI9
Gene name |
dnaE (Cj0718) |
Protein name |
DNA polymerase III subunit alpha |
Names |
|
Species |
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) |
KEGG Pathway |
cje:Cj0718 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9PPI9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9PPI9-F1 | Predicted | AlphaFoldDB |
No variants for Q9PPI9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9PPI9 | |||||
No associated diseases with Q9PPI9
5 regional properties for Q9PPI9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Polymerase/histidinol phosphatase, N-terminal | 8 - 75 | IPR003141 |
| domain | PHP domain | 9 - 188 | IPR004013 |
| domain | Bacterial DNA polymerase III, alpha subunit, NTPase domain | 321 - 593 | IPR011708 |
| domain | DNA polymerase, helix-hairpin-helix motif | 835 - 930 | IPR029460 |
| domain | DNA polymerase III alpha subunit finger domain | 596 - 759 | IPR040982 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQFTHLHLH | TEYSLLDGAN | KLKELALTLK | EQGATSVAMT | DHGNMFGAID | FYQTMKAQGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPIIGIEAYL | HNHDELDDKS | SRQRFHLCLY | AKNEIGYQNL | MYLSSQSYIK | GLYYYPRINK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLLEDYSEGL | ICSSACLQGE | VNWHLNTYSE | RNVRFGAKGY | EAAKEAALWY | KKVFKDDFYF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EIMRHGIGDQ | RMIDDDIIRL | SKELNIKIIA | TNDTHYTFKE | RAAAHEVFMC | IAMGKKLNDP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DRMRHSVHEF | YVKSPEQMSE | LFADIPEAIE | NTQEIAQKCN | LELNLGNPTP | PNFKFTREYA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KDHNIILPEE | TKEFSFDNDD | MVFEELCKKG | LEERLKFIDE | SKHEEYKQRL | EVEINIIKNM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFSGYMLIVH | DFIKVAKDKG | IPVGPGRGSA | AGSLVSYCLR | ITDLDPIPYS | LLFERFLNPE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RVSMPDIDVD | FCQDRRAEVI | DYVIDKYGAD | KVAQVITFGK | LLAKGVIRDV | ARVCDMSIQD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADELAKLVPE | ELKITLDAAY | EKEPKIKEFI | DRHPKGLEVW | EYARALEGLN | RNAGMHAAGV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VISNESLWKK | TPLFRQSKND | ERHLVTQYSK | DHLEDVDLIK | FDFLGLKTLT | VINNAIKLIK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KRYNKDIIWE | TIDVNDSKVY | KTIQSGNTLG | IFQIESGGMQ | SLNARLKPER | FEDIIAVLAL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YRPGPMESGM | LDDFIDRKHG | LKSIEYPFDS | LEKVLEPTYG | VIVYQEQVMQ | IVQIIGGFSL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GGADVVRRAM | GKKDPEKMKK | LKTDFADGAE | KQGYDRAKAE | DLWELIVKFA | GYGFNKSHSA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| AYALITFQTA | YLKTYYPSEF | MAALLTSEEN | NVDKIAVYID | EMKKMNIKLL | PPSINKAIRE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| FSALEQDGKD | AIIYGLGAIK | SVGIPAVENL | LEARQDGEFK | DINDFLGKID | PTKINRRTLE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SLIKAGAFDE | FGFTRKALFD | NMENLSEASR | KMAEVRKNAA | SSLFGEEELT | SGVQVNFTPK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| NEEFEVMEKL | GYEKEILGIY | VSGHPLDRFY | EQINAIDYVK | SLDFESLKNN | GEILSIGKIE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| DFKSMMSKNN | KRYGRIEILD | YYSSFDATVF | ESNVEEIENI | IKDENLKNNA | YGFVLGFKAE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| GGEKPSFFLK | AIKDLQSLED | GEIKAIKKFG | AKKDFKNKEE | NHFTAEPKEF | EKNIIELDLT |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| RLNRELIYEI | HEIARNAHNP | NEKNNKKLVL | KVISAGSCLL | YHTDFIISDS | IVEEISNKYA |